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Biomedical subjects

T Nambu

Publications and source records attributed to T Nambu.

At least 37 records · Page 2Linked to original sources
PubMed1993

The trophic effects of long chain triglycerides on the atrophic ileal mucosa of rats.

Rats with atrophic intestinal mucosa due to enteral nutrition supplied by an elemental diet (ED) for 4 weeks or more, received a fat-enriched ED containing 10% long chain triglycerides (10% FED) orally. The atrophic ileal mucosa became trophic 4 weeks after administration of the 10% FED. Ornithine decarboxylase activity in the ileal mucosa increased 3 days after the administration of 10% FED. Rats with atrophic intestinal mucosa that had undergone a 70% proximal jejunoileectomy, received an oral ED containing 4% long chain triglycerides (4% FED). In the jejunoileectomized rats, marked proliferation of the remaining ileum was observed irrespective of diet, when compared with the transected control group. In the transected group, the 4% FED had trophic effects on the ileum, but in the jejunoileectomized group, the 4% FED had no significant trophic effect on the remaining ileum. In conclusion, long chain triglycerides had mild trophic effects on ileal mucosa and were effective in the treatment of atrophic intestinal mucosa. However, the trophic effects of fat were apparently masked by the marked proliferation of the ileal mucosa following jejunoileectomy.

Animals↗
PubMed1993

Polymerization shrinkage and contraction force of composite resin restorative inserted with "Megafiller".

This study quantified the contraction force and polymerization shrinkage of composite resins with/without beta-Quartz Glass Ceramic Inserts (BQCI) as "Megafiller". The materials used for the determination included a chemically cured composite and five light-cured composites. The system for measuring contraction force consisted of a transparent teflon tube for preparing the specimen, a small load cell, a dynamic strain gauge and a pen-recorder. After the composite was packed into the teflon mold, a BQCI (Type R3) was inserted through the opening and the specimen was cured. Linear polymerization shrinkage of the composites was measured every 10 seconds from the start of mixing or irradiation to 90 minutes by the mercury bath method. Three pieces each of BQCI (Type T3) were inserted in each specimen. The results suggested that BQCI was markedly effective in reducing polymerization shrinkage, but was not always effective in reducing the contraction force during polymerization.

Acrylic Resins↗
PubMed1991

Deformation of the distal femur: a contribution towards the pathogenesis of osteochondrosis dissecans in the knee joint.

Osteochondrosis dissecans (OD) is a process of subchondral bone necrosis occurring predominantly in young individuals at specific sites. The aetiology of this disease remains controversial with mechanical processes due to trauma and/or ischaemic factors being proposed. This study aims at explaining the aetiology of OD in the knee joint as a result of the particular deformation of the condyles. A finite element analysis of the distal third of the femur was performed. A three-dimensional model was developed based on computed tomography scans of a normal femur, consisting of cortical bone, cancellous bone and articular cartilage. This model was subjected to physiological loads at 0, 30, 60 and 90 degrees of knee flexion. A complex deformation was found within each condyle as well as between the two condyles. Both medial and lateral condyles are deformed in the medio-lateral direction and at the same time compressed between the patella and the tibia in the antero-posterior direction. This effect is highest at 60 degrees of knee flexion. In both planes, the medial condyle is distorted more than the lateral one. Strain concentration in the subchondral bone facing the patella varies with flexion, especially for angles exceeding 60 degrees. The deformation of the femur in the predominant locus of OD in the medial condyle exceeds that of the lateral condyle considerably. The analysis shows that repeated vigorous exercise including extreme knee flexion may produce rapidly changing strains which in turn could ultimately be responsible for local subchondral bone collapse.

Biomechanical Phenomena↗
PubMed1991

Influence of water on the transverse strength of posterior composite resins.

In an attempt to evaluate the influence of water on the mechanical properties of composite resin, the transverse strengths of 15 commercially available composites were determined in water at 37 degrees C and compared with the strength measured in air after storage in water for periods of 1 day to 3 months. Some of the composites, including two which contained a blend filler, showed remarkable reduction of transverse strength when measured in air, according to the procedures specified in ISO 4049, in comparison with transverse strength measured in water. The change of water content in the material can predominantly affect the mechanical behavior of composite resin.

Composite Resins↗
PubMed1990

[Late adverse reactions of non-ionic intravenous contrast media].

A prospective study of late adverse reactions of non-ionic intravenous contrast media was performed. Information was collected from questionnaires returned by the patients, and also from further interviews. The incidence of adverse reactions was 8.3% in all patients, and was higher in female (11.1%) than male (5.8%). They were more frequent in the patients with age ranging from 20 to 49 than those older than 50. The most frequent symptom was headache, followed by itching, skin rashes, nausea, dizziness, and general fatigue. More than half of the reactions occurred within six hours after injection, but reactions a few days later were also reported.

Adolescent↗
PubMed1990

[A randomized trial of single and multifraction radiation therapy for bone metastasis: a preliminary report].

From April, 1989 through January, 1990, a randomized trial was conducted to investigate the efficacy of single fraction radiation treatment (8, 10, 12, 15Gy) compared to a multifraction dose schedule (5Gy x 4, 5Gy x 5, 5Gy x 6) as a therapy for a bone metastasis. Both subjective and objective pain scores were used to measure the therapeutic results. A total of 31 patients participated in the trial and, for analysis, 27 of these patients were follow-up for more than 8 weeks after the start of the radiation therapy. The following statistics resulted. Of the single fraction series, symptomatic pain relief was obtained in 86% of the patients (12/14 treatment areas), and of the multifraction series, 92% (12/13). Further, a complete response was achieved in 57% (8/14) of the single fraction patients and 31% (4/13) of the multifraction patients, respectively. Between the two treatment regimens, no difference was found in the incidence of pain relief, speed of onset, or acute morbidity. Finally, no severe morbidity was seen in either arm.

Adult↗
PubMed1990

[A case of icteric hepatoma with laryngeal metastasis and coexisting pancreatic cancer].

An autopsy case of a hepatocellular carcinoma with an omental mass, a laryngeal metastasis, and a coexisting pancreatic head carcinoma is reported and the diagnostic problems it presented is discussed. An obstructive jaundice was treated by transhepatic drainage, and was proved to be caused by the invasion into the bile duct of the hepatocellular carcinoma and not the pancreatic head tumor. An asymptomatic, papillomatous growth from the metastasis of the hepatocellular carcinoma was found in subglottic region, an extremely rare type of metastasis .

Adenocarcinoma↗
PubMed1990

[Intrahepatic bilomas after hepatic arterial embolization of malignant hepatic neoplasms].

Reviewed and discussed are six cases of intrahepatic biloma that developed after hepatic arterial embolization therapy for malignant hepatic tumors. All six cases were administered emulsion of adriamycin and lipiodol and/or sponge gel particles, as the etiology of their disease was considered to be bile duct necrosis due to obstructions of peripheral supplying arterial branches. From the 23rd to the 76 days after embolization therapy, each lesion was detected by CT scan, and every case showed an elevation of serum alkaline phoshatase. Further, in 4 cases, hepatobiliary scintigraphy revealed a delayed bile clearance in the hepatic lobe. In one case followed up for 2 months, only one of two lesions disappeared. And in 5 cases that were followed up for more than 4 months, recovery occurred in 4 cases without any further treatment, but another case required percutaneous drainage for 3.5 months to be cured. An intrahepatic biloma, or bile duct necrosis, is a complication that can arise from hepatic arterial embolization therapy, so that careful follow-up must be given.

Aged↗
PubMed1990

[Ultrasonography of the extremities: nontumor lesions].

Ultrasonographic imagings of non-tumor disorders in extremities were reviewed and discussed. All cases underwent surgery. In our retrospective evaluation, US was found to be effective in cases of tendon injuries, articular osteochondritis, tenosynovitis and the displacement of chondral navicula in infantile club foot, etc.

Adolescent↗
PubMed1990

[CT in gallbladder cancer; especially the extension of the tumor].

An efficacy of CT in the preoperative staging diagnosis of gallbladder cancer was evaluated. CT findings were recorded following general rules for surgical and pathological studies on cancer of biliary tract proposed by Japanese society of biliary surgery. Serosal invasion (S factor), direct hepatic invasion (H inf factor), lymph node metastasis (N factor), bile duct invasion (B factor), duodenal invasion (Du factor) and finally preoperative staging diagnosis were included in this study. Conclusion is as follows. 1) False positive results were predominating in S and H inf factor, sensitivity was 76.0% and 50.0% respectively. 2) In B factor, the result was poor, the sensitivity 44.4%. 3) In N factor, CT was effective, the sensitivity 77.6%. 4) Finally it was concluded that CT can play an important role in staging diagnosis of gallbladder cancer, the sensitivity was 93.1%.

Bile Ducts↗
PubMed1990

[CT in staging gastric cancer].

CT pictures of 26 cases of advanced gastric cancer were reviewed. All the cases of gastric cancer were staged surgically and also histologically. 1) Gastric cancer was enhanced intensely. 2) About the diagnosis of the extension of the tumor, there were many problems to be solved in the future, but the result of final staging was satisfactory. 3) With further advent of technology and methodology in the field of CT, CT will play an important role in staging diagnosis of gastric cancer.

Humans↗
PubMed1989

Chronotropic effect of the methanolic extracts of the plants of the Paris species and steroidal glycosides isolated from P. vietnamensis on spontaneous beating of myocardial cells.

Rhizomes of five identified plants of the Paris species, Liliaceae, and Rhizoma Paridis which are sold as a crude drug named "Zao Xiu," "Qiyeyizhihua" or other names in nine different markets in China were tested for their effects on cultured cardiomyocytes. In the standard medium, eight methanol extracts out of sixteen at a concentration of 0.2 mg/ml stopped the spontaneous beating of myocardial cell sheets, but these extracts significantly increased the beating rate when the concentration was reduced to one half. In the culture medium with a low calcium concentration, 0.5 mM, the beating rate of the cells decreased to about 60% of that of the control in the standard medium. The addition of five of the extracts to the low calcium medium at a concentration of 0.1 mg/ml caused a stop of cell beating, but the other extracts increased beating rate at least by 10%. These steroidal glycosides isolated from the rhyzomes of P. vietnamensis (Takht.) H. Li also stimulated cell beating. Among them, diosgenin-3)-alpha-L-rhamno-pyranosyl-(1---2)-(alpha-L-arabinofura nosyl-(1---4))-D-glucopranoside (compound 1) was the most effective stimulant for cell beating as well as calcium uptake by the myocardial cells.

Animals↗
PubMed1989

[Radiotherapy of a pure seminoma of the testis].

Twenty-six cases of a pure seminoma of the testis that had been treated by postoperative radiotherapy have been reviewed. The overall 5-year survival rate was found to be 92.3%. Further, no severe adverse effects, including sterility, was found. Prophylactic mediastinal radiation is considered to be unnecessary, because supradiaphragmatic lymph node metastasis was seen in only 1 patient, who has remained disease-free 4.5 year after the treatment of a recurrence. Extranodal metastasis was seen 5 cases, 2 of these cases showing bone metastasis that was successfully treated, thereby achieving complete remission. A seminoma is considered to be one of the most curable malignant diseases, however, long-term follow up is a necessity since stage 1 seminoma has been found to show a generalized dissemination after a 16-year, disease-free interval.

Adult↗
PubMed1989

[CT of pulmonary eosinophilic granuloma].

CT findings of four cases of pulmonary eosinophilic Granuloma were discussed. In three cases, multiple nodular shadows or multiple cavitary lesions were observed in upper and middle lung field predominant. However, in one patient who had history of recurrent pneumothorax, CT revealed a honeycomb appearance and some bullous change as well. These findings seemed to represent a far advanced state of the disease. X-ray CT is excellent in demonstrating such pathological changes, and is indispensable in the diagnosis and follow up study of pulmonary eosinophilic granuloma.

Adult↗