Quantitative alterations of serum lipoproteins were studied as well as lipidic peroxidation level and total antioxidant capacity in the serum of 265 subjects ranging in age between 60-70 years, out of which 97 showed levels of glycemia higher than normal. Increase of LDL and VLDL was found in 74.6% respectively 67% of the old-aged subjects researched, without also finding significant differences between sexes. Frequent association between the two metabolic disorders is seen without there being a statistical correlation between degree of dyslipidemia and blood glucose level. The level of lipid peroxidation, determined by serum malondialdehyde (MDA) concentration, is higher in subjects with dyslipidemia where glycemia level exceeds 200 mg%. Total antioxidant defence in old aged hyperglycemic patients decreases by 18% as against the value seen in the controls. The normally glycemic patients show a decrease in this activity by only 12%. Significant frequency of dyslipidemia in the old aged studied is associated with hyperglycemia and can be accounted for beyond biologic mechanisms characteristic of aging, through a deficient diet. Association of dyslipidemia with hyperglycemia, the high level of lipidic peroxides and the diminution of body capacity of annihilating them, actually represents an increase in risk factors for onset of vascular attacks.

Adult↗

PubMedDate not supplied

Antioxidant protection in collagen-vascular diseases.

Alteration of redox balance in the serum of patients with systemic lupus erythematosus (SLE) and systemic vasculitis (SV) was investigated. Excess in oxidative processes has been measured through concentration of lipid peroxides which was found to increase by 26% in SLE and 32% in SV. Antioxidant protection capacity against this oxidative aggression has been assessed both by determining the level of activity of the enzymes participating in this process (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase GSH-Px) and by determining the total antioxidant serum activity. The results have shown that, within antioxidant protection of the body against oxidative stress, glutathione peroxidase plays the most important role and its activity is significantly affected by the great concentration of lipidic peroxides. We have also shown that there is positive correlation (r = 0.91) between the level of lipidic peroxides and the extent to which the tissue is affected. The latter is assessed by studying the serum activity of lactate dehydrogenase. Therefore, these two biologic parameters are shown to be very useful when the study of the development of the diseases is undertaken.

Adolescent↗

PubMedDate not supplied

Oxidative injury and other metabolic disorders in hepatic encephalopathy.

Within the complex mechanism of hepatic encephalopathy resulting from alcohol poisoning, a significant pathogenic role seems to relate to lipid peroxides (free radicals generated by chronic alcohol poisoning itself). Oxidative aggression is emphasized by the diminishing antioxidative capacity of the body resulting from serious liver injury brought about by chronic ethyl poisoning. The poisoning influences the whole functional capacity of the liver, hepatic protein synthesis included, which also means ceruloplasmin and siderophilin synthesis; the two latter elements make up AOS Cp-Tr which neutralizes the harmful activity of Cu and Fe excess and stimulates release of free radicals of oxygen. The purpose of our research was to study the redox balance alteration in blood in a group of patients who were in a critical condition and had been admitted to the somatic patients ward of the "Prof. Dr. Alexandru Obregia" Neurology and Psychiatry Hospital and who were suffering from hepatic encephalopathy resulting from ethyl poisoning.

Alcoholic Intoxication↗

PubMedDate not supplied

Dynamic study of oxyhemoglobin in traumatic shock.

The dynamic study of oxyhemoglobin in general, and especially in traumatic shock, represents one of the aspects of pathophysiology which is of interest to practitioners as well as to pathophysiologists due to its relatively practical accessibility. The study was performed on two groups of 30 subjects: a healthy subjects group and a control group. The patients hospitalized in the Intensive Care Section of the Clinical Hospital Department of Constanţa represented the subjects of the control group. Using an Oximeter--AVL 912 oxylite, the arterial hemoglobin oxygen saturation, venous hemoglobin oxygen saturation and the calculation of arterio-venous oxygen difference were measured in their dynamics. The results showed a diminution of oxygen extraction at the tissular level. We also noticed a good correlation between oxyhemoglobin dynamics and the evolution of the patients during specific therapy.

Adult↗

PubMedDate not supplied

Circulating immune complexes in collagen diseases.

In a group of 75 patients with collagen diseases a study was carried out for the structural characterization of the circulating immune complexes (CIC) and the eventual detection of a correlation between these complexes and various serum biologic parameters. The results obtained have demonstrated: (a) the great variability of the structure of immune complexes even in the same type of disease and (b) the lack of correlation between the concentration of components in the CIC structure and the level of the same components in the serum. The lack of correlation may be explained by the great variety of immune complexes formation and the increase of any of the serum immunoglobulins does not necessarily mean its total or partial aggregation in the CIC structure.

Antigen-Antibody Complex↗

PubMedDate not supplied

Study on some reactivity aspects in chronical psychic-organic syndrome.

In the present work, a number of patients with chronic psychic-organic syndromes, with confuse states, with the exaggeration of some personality features during the beginning period of brain atherosclerosis or senility was studied. The anamnestic and psycho-organic syndromes in different dysfunctions degrees, the evolution of dysfunctions with vascular determination, the deficiency of some intelligence compounds were also investigated. We tried to analyse the psychometric results and to distinguish the functional dysfunction from the organic one using Raven's test, Thurstone's scale, WAIS scale and test. We also tried to distinguish the intellectual decrease of medium and deep level. We studied the reactivity, the plasma level of ACTH, ACTH-stimulation test, integrity of the hypophyseo-hypothalamic test. The multitude of results of paraclinical analysis correspond to the multitude of clinical syndromes. These studies are preliminary for a more thorough research of the physiopathology of this kind of patients. The detailed investigation of these patients' specific nature reactivity offers a lot of possibilities used for therapy.

Aged↗

PubMedDate not supplied

Metabolic investigations in persistent depressive states in the elderly.

In a group of 100 elderly patients with persistent depressive states, a series of investigations were carried out: hematologic, lipid, protein, energy metabolism hydroelectrolytic and acid-base balance, blood rheologic properties, immunologic, reactivity and certain humoral and regulation mechanisms. The results were compared with those obtained in two control groups, identical in number, the former in the third age without depressive states and the latter of healthy adults. The results were evaluated statistically. The results demonstrate that in depressive elderly subjects changes of the various parameters studied occur in the same direction as those in the group of elderly subjects without depression, but are far more accentuated.

Aged↗

PubMedDate not supplied

[Genetic concepts in antibody formation].

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Animals↗