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T Neufang

Publications and source records attributed to T Neufang.

14 recordsLinked to original sources

[Appendectomy 1997--open or closed?].

Unlike laparoscopic cholecystectomy, laparoscopic appendectomy (LAE) has not yet become popular. Are there no significant advantages? Or is the poor acceptance of LAE related to its longer learning curve, longer operative times and the need for additional equipment, which lead to some inconvenience when the procedure is done on an emergency basis? LAE may be performed as safely as open appendectomy (OAE) with fewer wound complications. Superior laparoscopic exploration allows an accurate diagnosis and reduces the rate of negative appendectomies. In contrast, postoperative pain, recovery and the cosmetic result are equal to or at best slightly better than in open surgery. Therefore, in the routine patients, there is no need to replace OAE by LAE. In the case of an uncertain diagnosis, the laparoscopic approach is generally superior, allowing thorough abdominal exploration. This has to be considered in each individual case; however, women with lower abdominal pain and suspected appendicitis will certainly benefit from laparoscopy, as well as older patients with an unclear diagnosis. The lower rate of wound infections is beneficial to obese patients and to patients with gangrenous or perforated appendicitis. Furthermore, the decision for one procedure or the other is influenced by the patient's individual preference and cosmetic aspects. The verifiable benefit of the laparoscopic procedure for certain categories of patients and the potential advantages in the individual case suggest that competent handling of laparoscopic technology will be required in future. Therefore, experienced surgeons should take more active interest in instruction and training--even when surgery has to be performed after hours.

Appendectomy

[Manually assisted laparoscopic surgery--realistic evolution of the minimally invasive therapy concept? Initial experiences with the "Endohand"].

The essential limitations of laparoscopic procedures--lack of palpation, problematic retrieval of specimen and anastomosis, etc.--are abolished by the hand of the surgeon, which is inserted into the peritoneal cavity through a mini-laparotomy. While holding the pneumoperitoneum, the hand acts as an intelligent instrument performing surgical exploration, exposition of the field of operation, blunt dissection or intracorporal knot-tying. The mini-laparotomy is used to insert conventional instruments and suture material, as well as for specimen retrieval and anastomosis. Our preliminary experience (3x splenectomy, 2x sigmoid colectomy, 1x anterior resection of rectum, 1x proctocolectomy with J-pouch) shows that even extensive laparoscopic operations are accomplished much more simply. The time spent for such procedures is markedly reduced.

Adult

[Laparoscopic diagnosis and therapy of closed traumatic diaphragmatic rupture].

Diagnosis of blunt diaphragmatic rupture is still a challenging problem. This injury is generally treated by direct closure of the defect via a laparotomy or a thoracotomy. As it occurs frequently in severely traumatized patients, we wondered whether those patients could benefit from the well-known advantages of minimally invasive surgery. We report the records of two patients who underwent laparoscopy for blunt diaphragmatic hernia. In both patients, the hernia was laparoscopically closed without opening the abdomen. We did not see any intra- or postoperative complications related to minimally invasive surgery; the postoperative recovery was impressively short. Taking into account the fact that diaphragmatic ruptures are frequently misdiagnosed, we recommend laparoscopy as a useful tool in cases where these injuries may be suspected. In selected patients, primary closure of the defect may be achieved within the same laparoscopy so that laparotomy can be avoided.

Adult

Laparoscopic resection of pheochromocytoma.

The following case report presents the diagnostic procedures, laparoscopic therapy, and postoperative course of a 48-year-old patient with pheochromocytoma. During the previous 15 years, he had occasionally presented with hypertension, intermittent attacks of severe perspiration, and tachycardia; no diagnostic measures were performed at the time. During an ultrasound examination of the abdomen performed due to gastrointestinal complaints, a 5-cm adrenal tumor was discovered incidentally. Further diagnostic procedures then indicated the presence of a pheochromocytoma which was resected laparoscopically. The anesthesia was tolerated well, although isolated systolic blood pressure peaks to 200 mmHg were observed. The laparoscopic tumor resection presented no problems, although identifying the tumor proved to be difficult and resulted in an extended operation time of 4 h and 20 min. The postoperative course was unremarkable. This case report presents our laparoscopic technique and confirms that techniques proven in the "open" resection of a pheochromocytoma can also be utilized in the laparoscopic approach.

Adrenal Gland Neoplasms

[New trends in biliary surgery].

On the basis of the experience gained in 893 laparoscopic procedures performed on the gallbladder, and with increasing frequency on the bile-ducts, and on the basis of a comprehensive review of the literature from 1992 and 1993 pertaining to this subject, a critical analysis of laparoscopic gallbladder surgery has been accomplished. As substantiated by recent publications, laparoscopic cholecystectomy has achieved wide acceptance in surgical practice. Over the course of the last two years, discussion has focussed on the avoidance of injury caused by Veress needle and trocar puncture and specific pneumoperitoneum-associated complications, as well as the minimisation of overlooked and/or spilled bile-duct calculi and the avoidance of iatrogenic bile-duct injuries. Procedures to be taken in order to achieve the necessary improvement in laparoscopic cholecystectomy are described.

Adult

[Intraoperative cholangiography and anterograde bile duct exploration in laparoscopic cholecystectomy--technique, results, perspectives].

The avoidance of (unrecognized) bile duct injuries (1) and the management of bile duct stones (pre-, intra- or postoperatively?) (2) are believed to be the main problems in laparoscopic cholecystectomy (LCE) at present. They must be a challenge for surgery to develop and improve the concepts of minimally invasive therapy for treatment of cholelithiasis. Intraoperative cholangiography (IOC) plays a very important role and is the basis of innovative, laparoscopically assisted procedures (3) for single session therapy of gallbladder and bile duct stones. (1) A detailed analysis of the literature proves the value of IOC for avoidance or early recognition of iatrogenic bile duct injuries. IOC is of most importance to compensate fundamental restrictions of the laparoscopic technique (missing possibility for palpation or anterograde preparation). IOC adds additional safety to the laparoscopic procedure and detects unsuspected bile duct stones. (2) At present, surgical management of cholecysto-/choledocholithiasis is split in two independent procedures: LCE and pre- or postoperative endoscopic retrograde cholangiography (ERC) with optional endoscopic papillotomy (EPT). A critical analysis of the literature and of the results of 623 LCE performed between 10/91 and 9/93 in the own institution leads to the following conclusions: Preoperative ERCs are performed unnecessary in about 50% of cases. They could be avoided by routine use of IOC. The combination of two independent procedures (LCE and ERC/PT) for treatment of cholelithiasis increases mortality and morbidity. Thus, the outcome of "therapeutic splitting" is not clearly superior to conventional treatment by open surgery.2+ common bile duct exploration allows final diagnosis and treatment in a single session. Additional risks and costs caused by choledochotomy as well as by pre- or post-operative endoscopic retrograde procedures (ERC, EPT) are avoided.(ABSTRACT TRUNCATED AT 250 WORDS)

Cholangiography

[Initial experiences with laparoscopic fundoplication].

Over the past decade decreasing numbers of anti-reflux surgical procedures have been performed. The two main reasons are improved pharmacotherapeutics and the complication rate associated with anti-reflux surgery. But in patients who are medically refractory or in those requiring long-term medications the Nissen-Rossetti fundoplication still has its place in the therapy of reflux disease. Laparoscopic procedures have begun to replace many conventional operations and have pushed surgeons to use this technique in antireflux surgery. Since April '92 we planned laparoscopic Nissen-Rossetti fundoplications in 22 patients. 21 operations were carried out laparoscopically (1 conversion). There were no intraoperative complications. 1 patient suffered from 10 weeks dysphagia. Oesophagitis was healed in 19 patients and improved (grade IV to I) in 2 after 12 weeks. Our results demonstrate that laparoscopic fundoplication is a proven alternative to open surgery. In the future the possibility of avoiding costs and risks of lifelong drug therapy will help to establish well indicated laparoscopic fundoplication.

Female

[Laparoscopic hernioplasty].

We report our experience with laparoscopic repair of inguinal hernias since Dec. 1990. The initially used "plug & patch-technique" was abandoned because of high recurrence rates for primary hernias and other disadvantages. In Feb. 1992 we started with a transperitoneal-preperitoneal repair using closure of the defect with sutures as well as posterior wall reinforcement with polypropylene mesh. Based on established conventional techniques, the procedure has evolved and results in quick recovery and low recurrence rates. As compared to anterior techniques, a superior repair of large posterior wall defects, bilateral, femoral and especially recurrent hernias is achieved. Disadvantages are the transabdominal approach and the need of general anesthesia. The technique used in Göttingen is presented in detail. Between 2/92 and 9/93 we repaired 249 hernias (including 44 recurrences) in 207 patients. Major complications were observed in 1.6%. Up to now, we found 4 recurrences (1.6%, follow-up 87%, 5-24 months).

Adult

[Critical evaluation of laparoscopic hernia surgery].

The success of the laparoscopic cholecystectomy was remarkable and well-founded, thus it seems necessary to examine whether this procedure could be also used for other general surgical operations. Since Dec. 29th, 1990 the transperitoneal repair of hernias by laparoscopy has been performed in 177 patients. The patients were followed up in regular intervals. The first 100 patients were treated with the "plug repair" technique of Schultz and Corbitt. In this group one recurrence (4 month after operation) and one dislocation of a mesh roll (2 weeks after the operation) were observed. In the middle of April 92 we changed the laparoscopic operation technique to a preperitoneal mesh fortification analogous to the procedure of Stoppa. This requires a detailed preparation of all possible positions of the hernia (medial and lateral compartment). A cutting through all layers of the abdominal wall can be avoided. After the preparation all abdominal wall defects can be fortified effectively and clearly. In this group we have treated 77 patients, so far without complications. With the exception of scrotal hernias and adhesions the laparoscopic hernioplastique can be used in any indication of inguinal hernia repair. An evaluation of the long-term results can only be performed in the future although the early results are encouraging.

Equipment Design

[Specifics of anesthesiology in the operative phase of laparoscopic surgery].

AIM OF INVESTIGATION: The present investigation was initiated to quantify the effect of a CO2-peritoneum on CO2-absorption (VCO2res) and other respiratory variables during laparoscopic surgical procedures. METHODS: Gas exchange and endtidal pCO2 (petCO2) were measured continuously. Ventilation was adjusted to maintain preoperative petCO2 mainly by increasing the tidal volume. Arterial blood gas samples were taken directly before starting and directly before the end of the CO2-peritoneum. RESULTS: In 49 patients a complete set of data was evaluated for a mean duration (+/- 50) of 99 (43) min CO2-peritoneum. The mean VCO2res was 37 (30)ml/min. The VCO2 showed a steady state of 137 (29)ml/min before the start of the operation. Individual VCO2res maxima of 223 ml/min were detected. Due to a mean rise of arterial pCO2 (paCO2) of 39 (3.6) to 42.6 (4.5) mmHG the VCO2res was underestimated by about 5 ml/min. This CO2 accumulation was mainly the result of an increasing petCO2-paCO2 difference till the end of the CO2-peritoneum. No significant change in VCO2res has been detected with increasing duration of the CO2-peritoneum, though in individual courses a continuously increasing VCO2res was found. Overweight individuals (n = 17) showed a significantly lower VCO2res of 23 (12)ml/min in comparison to normal weight patients (n = 34) with 43 (16)ml/min. The static total compliance was significantly reduced by 30% at the end of the CO2-peritoneum. The ventilatory deadspeace/tidal volume relation did not change. To maintain normocapnia the average alveolar ventilation had to be increased by 38% till the end of the CO2-peritoneum. CONCLUSIONS: This increase in ventilation can easily be established in pulmonary uncompromised patients. Problems in adequately increasing minute volume are expected in chronic obstructive lung disease and with maximal VCO2res. Monitoring of at least petCO2 is strongly recommended since the individual course of VCO2res cannot be predicted.

Adolescent

[Endoscopic hernia repair].

A laparoscopic procedure for surgical hernia repair is reported. In comparison to other methods we do not only remove the peritoneal sac, but close although the inguinal canal with a nonresorbable marlex mesh. Up to now we practiced this technique in 35 patients. First post-operative results are encouraging but nothing can be said about longterm results, especially the recurrence rate.

Adolescent

Treatment of iatrogenic common bile duct injury during laparoscopic cholecystectomy through the laparoscopic insertion of a T-tube stent.

Iatrogenic injury to the common bile duct during laparoscopic cholecystectomy has previously necessitated an immediate laparotomy to alleviate bile leakage. In the course of 171 laparoscopic cholecystectomies performed at our hospital, intraoperative common bile duct injuries occurred in 2 patients. Each case was successfully treated using a laparoscopically placed T-tube, thus avoiding the need for a laparotomy. This novel intraoperative procedure successfully treated common bile duct injuries without resulting in postoperative complications.

Adult

Bombesin--the most stimulating peptide of human gastric smooth muscle.

The mechanical activity of isolated muscle strips from different regions of 33 human stomachs was measured under auxotonic conditions. After application of bombesin (stepwise increases in organ bath concentrations 10(-9) to 10(-6) mol/l) the following in vitro effects were observed in human gastric muscle: (1) Bombesin stimulated both circular and longitudinal preparations from all regions of the human stomach and circular duodenum. (2) The quality of the responses to bombesin application was dependent on the general myogenic characteristics of the preparations of the different stomach regions. The contraction pattern changed at high bombesin concentrations in the organ bath to slower fluctuations. (3) Bombesin resulted in a maximal tonic response in the pyloric region preparations. An increase in tone was usually observed in the inner pyloric preparations, being typical for the region. (4) The effects of bombesin on the human stomach were stronger than the effects of many other regulatory peptides and of the reaction to acetylcholine. (5) The bombesin-induced effects were unaltered by pretreatment with atropine or TTX. (6) The response to bombesin frequently lasted for hours after washing before reassuming the original state.

Acetylcholine

Cisapride effects on canine lower esophageal sphincter under various pharmacological pretreatments.

Cisapride (Ci) stimulates lower esophageal sphincter pressure (LESP). This study aims to test whether the effect of Ci on LES in vivo is still present if LES is relaxed by atropine (Atr) and nifedipine (Nife) prior to the administration of Ci. LESP was continuously recorded by manometry in 6 mongrel dogs with esophageal fistulae. Ci was given as an intravenous bolus following either Atr (40 micrograms/kg i.v.) or Nife (20 mg subl.) at the time of maximal LESP decrease (5/15 min later). Basal LES values ranged between 24.5 +/- 2.5 mm Hg (Atr group) and 23.8 +/- 3.9 mm Hg (Nife group). Following Atr, LESP decreased to a minimal value of 7.0 +/- 0.5 mm Hg; after Nife LESP decreased to a minimal value of 12.3 +/- 2.0 mm Hg. Additional administration of Ci was not able to reincrease LESP. We conclude that the action of Ci on LES cannot take place if (1) muscarinergic receptors are blocked by Atr and (2) the Ca2+ activation system is blocked by Nife. Our results suggest that the action of cisapride on LES, as its action on gastrointestinal smooth muscle cells, is mediated by postsynaptic enhancement of acetylcholine release.

Animals