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T Nikkari

Publications and source records attributed to T Nikkari.

133 records · Page 8Linked to original sources
PubMedDate not supplied

Nutrient intake and blood lipids in children.

Nutrient intake and serum total cholesterol (C T), serum high density lipoprotein cholesterol (HLD), triglycerides (TG) and fatty acids were evaluated from 692 3-year, 8-year and 12-year-old children in different areas in Finland. Serum/plasma TC concentrations varied from 4.8 to 5.0 mmol/l, HDL from 1.3 to 1.5 mmol/l and TG from 0.70 to 0.87 mmol/l. 12-year-old boys consumed significantly more energy than girls at the same age. In the 8-year-old boys the quality of fat used on the bread and quality of milk drunk influenced on the serum fatty acid composition, the proportion of linoleic acid being greater in those children who used margarine and/or low fat milk. The 3-year-old children at the highest quartiles of TC concentration used less wheat products and their intake of riboflavin was less than children in the lowest quartile. HDL concentration was associated with the intake of thiamine. The 12-year-old children having their TC concentrations in the highest quartile used more saturated fats and got more saturated fatty acids than children in the lowest quartile. The higher the sugar consumption and sucrose intake were, the lower was the HDL concentration. The prevalence of obesity increased with the age, being 0.5%, 5.0% and 8.5% in the 3-year, 8-year and 12-year-old children respectively. Urban children were more commonly obese than rural children, the prevalence being 8.0% versus 2.2% (p less than 0.01).

Child↗
PubMedDate not supplied

Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade.

We examined the effects of beta-blockade with the nonselective antagonist propranolol, the cardioselective antagonist atenolol, and the cardioselective antagonist with partial agonist activity, practolol, on the levels of free arachidonic acid (AA), thromboxane B2 (TxB2), prostaglandin (PG) E2, and 6-keto-PGF1 alpha in plasma, and TxB2 production by platelets during clotting in six normal subjects during submaximal dynamic exercise. The drugs were given intravenously in equipotent increasing doses before the exercise test. Exercise induced a clear increase in AA, TxB2, and 6-keto-PGF1 alpha in plasma. During the first 60 min of exercise all three beta-blockers decreased the plasma levels of AA and TxB2. Propranolol (0.19 mg/kg) was slightly more effective than atenolol (0.19 mg/kg) or practolol (0.64 mg/kg); however, at exhaustion, propranolol was markedly more effective than the other two blockers. Plasma 6-keto-PGF1 alpha and PGE2 levels were less affected by beta-blockade during exercise, and no significant effect was seen on TxB2 formation by platelets. The plasma 6-keto-PGF1 alpha/TxB2 ratio was markedly higher after propranolol treatment than after treatment with the other two blockers during the exercise period. These results suggest that the capability of a nonselective blocker to inhibit both beta 1- and beta 2-adrenergic receptors may be of advantage because of the more effective inhibition of thromboxane formation than with a cardioselective blocker, especially when the sympathetic tone is markedly increased.

6-Ketoprostaglandin F1 alpha↗
PubMedDate not supplied

Biochemical composition of coronary arteries in Finnish children.

To study the early features of atherosclerosis, we analyzed coronary artery intima medias from 63 boys and 30 girls who were newborn to 15 years old at the time of accidental death. Fatty streaks were found in five boys and one girl and, with one exception, were not present until the second decade of life. From birth there was a continuous increase in esterified cholesterol (EC) and a two- to threefold rise in free cholesterol and phospholipid. DNA, total protein, and collagen tended to rise after the first decade. The content of hyaluronic acid remained fairly constant, but sulphated glycosaminoglycans (GAGs) rose during the second decade; the highest increases were in dermatan and chondroitin sulphates. The content of arterial EC showed significant positive correlations with those of GAGs, but associations with the contents of DNA, total protein, and collagen were not significant. As judged by the observed gradual increase in arterial EC and a change in its fatty acid composition, there is a continuous increase with age in LDL-derived EC in the arterial wall. The mechanism of this accumulation is unknown, but the findings provide circumstantial evidence to support the concept that arterial GAGs may cause retention of plasma-derived lipids, which may subsequently be altered and internalized by the intimal cells.

Adolescent↗
PubMedDate not supplied

Glycosaminoglycans and apolipoproteins B and A-I in human aortas. Chemical and immunological analysis of lesion-free aortas from children and adults.

To study changes in the contents of plasma lipoproteins in human arteries with age and the relationship of lipoproteins with other arterial constituents, we analyzed the contents of apolipoproteins B (apo B) and A-I (apo A-I), free and esterified cholesterol, and glycosaminoglycans (GAG) in lesion-free aortic intimas of 30 children and adults. The content of apo B increased significantly with age, whereas that of apo A-I remained relatively constant. Apo B and apo A-I had significant positive correlations with the content of chondroitin sulphates A + C (CS A + C), which comprised 35% to 47% of the aortic GAG. The correlations remained significant after correction for the effect of age. Aortic apo B, but not apo A-I, also showed significant positive correlations with the contents of intimal free and esterified cholesterol. The results indicate that: considerable amounts of apo B and apo A-I can be found in lesion-free aortic intimas; there is an age-related rise in the content of apo B and a fall in the ratio of apo A-I to apo B, which are unfavorable developments in the light of current views on atherogenesis; the contents of the apolipoproteins are proportional to that of CS A + C, which might have a role in the retention of lipoproteins in the arteries.

Adolescent↗