[Acute idiopathic pericarditis evolving into constrictive pericarditis].
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Acute Disease↗
Biomedical subjects
T Nikolov
Publications and source records attributed to T Nikolov.
[The Breddin test in various forms of idiopathic thrombocytopenic purpura].
In 100 healthy persons and 38 patients with idiopathic thrombocytopenic purpura (ITP) the morphology of thrombocytes was examined according to BREDDIN. The survival time of the marked thrombocytes and their place of sequestration was determined in the patients and in 17 voluntary persons. A correlation was found to exist between the morphology of thrombocytes and those four forms of ITP which could be limited by means of radiometric methods. Moreover, a certain degree of dependence was found between the thrombocyte sequestration place and the presence of antibodies.
Agglutinins↗
[Influence of cyclophosphamide on the production of experimentale autoimmune encephalomyelitis (author's transl)].
The aim of the so carried out experiments is to establish whether the created disbalance between T- and B-lymphocyte populations influences the final stages of a cell-mediated reaction in vivo. The chosen model was one of experimental autoimmune encephalomyelitis (EAE). Guinea pigs were given a single challenge (intradermally in the hind foot-pads) of 70 microgram myelin basic protein (MBP)--isolated from bovine spinal cord--in complete Freund's adjuvant (CFA). Another group of animals was treated intraperitoneally with 200 mg/kg cyclophosphamide (CY) 3 days before the MBP-CFA challenge. The control group received only CY. At different times after the administration of MBP, CY or CY-MBP, the popliteal lymph nodes have been examined and the morphological changes together with the number of anti-MBP antibody synthesizing cells (ASC) were recorded. In the guinea-pigs treated with the CY 3 days before the antigen challenge the disease develops earlier and shows a degree of severity with a threefold greater mean score. The number of ASC is increasing up till the 10th day and slightly decreases toward the 20th day when there are clinical and histological signs of EAE. If MBP is administered after a 3-day action of CY, the number of these cells till the 7th day after the antigen challenge is strongly reduced, then surpasses the normal value about the 10th day and comes back to it towards the 20th day. The results so obtained confirm the concept of the T-lymphocyte mediation of EAE and give us grounds for discussing the CY action on the lymphocyte subpopulation.
Animals↗