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Biomedical subjects

T Ninchoji

Publications and source records attributed to T Ninchoji.

At least 19 recordsLinked to original sources

Multilevel anterior cervical fusion using skull bone grafts. Case report.

The successful use of autogenous skull bone grafts for a C3-7 anterior cervical fusion is reported and compared with results using other bone grafts. A 51-year-old man with C4-7 anterior cord compression due to spurs and ossified posterior longitudinal ligaments developed progressive tetraparesis following a minor head injury. He underwent anterior decompression and fusion. On two occasions an iliac graft had failed; however, a graft of autogenous skull bone was successful. The skull bone was found superior to bone from other sites, such as the iliac crest, rib, tibia, and fibula, showing sufficient strength and less morbidity. The skull may be a better source of graft material for multilevel anterior cervical fusion, which requires long and strong grafts.

Cervical Vertebrae

[Long-term prognosis of nonoperative acute epidural hematoma in children].

Computed tomography(CT) scan has revealed that certain acute epidural hematomas(AEH) don't need operative therapies. But, it is difficult to determine especially in childhood, whether AEH compressing the brain for a short-term would or would not effect the function of the central nervous system in the future. For this reason, the authors report the long-term prognosis of nonoperative AEH in children. Twelve children suffering from AEH were transported to our clinic. On admission, they had no neurological deficits and CT scan revealed hematomas that had maximum thickness of 5-19 mm without midline shift. With nonoperative therapy they were discharged and the hematomas disappeared within 3-12 weeks. After long-term follow-up (3-10 years), it was shown that they had no epileptic episodes, and no changes in their school study records. Also, the Yatabe-Guilford personality test revealed no abnormal data. These data suggest that children can be cured who suffer from AEH with no neural deficits, and in whom the maximum thickness of the AEH is less than 20 mm, and in whom there is no midline shift in CT scan, can be cured without undergoing an operation, and will have a good long-term prognosis.

Acute Disease

Post-irradiation vasculopathy of intracranial major arteries in children--report of two cases.

We report two rare cases of post-irradiation vasculopathy of intracranial major arteries in children. A 13-year-old girl suffered from transient right hemiparesis 1 year after irradiation for suprasellar germinoma. Left carotid angiograms revealed marked stenoses of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries, which were previously normal, and moyamoya vessels. A 2.5-year-old girl underwent internal irradiation with 198Au colloid for cystic craniopharyngioma. At the age of 10 years, she suddenly became unconscious after vomiting. Computed tomographic scans showed a right frontal intracerebral hematoma. Right carotid angiograms disclosed complete obstruction of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries and moyamoya vessels, previously not present. The danger of radiation therapy causing occlusive vasculopathy in small and major cerebral arteries in children is emphasized. To prevent permanent ischemic neurological deficits, vasculopathy should be treated either medically or surgically as early as possible.

Adolescent

Cerebellar ganglioglioma--case report.

A 14-year-old boy presented with cerebellar ganglioglioma manifesting as severe headache and confusion. Computed tomographic scans showed a huge, partly enhanced cystic cerebellar tumor. The tumor was totally removed. Histological examination disclosed glial cells and mature ganglion cells. The latter were identified by Nissl's staining and immunostaining for neurofilaments. Ganglion cells were present in the cerebellum and the surrounding subarachnoid space. This heterotopic growth of ganglion cells enabled a firm diagnosis of cerebellar ganglioglioma.

Adolescent

[Involuntary movement complicated with the postoperative stage of ruptured aneurysm: a case report].

Involuntary movement complicated with the postoperative stage of the ruptured cerebral aneurysm is extremely rare. And, the pathophysiology of the involuntary movement has not been established yet. The authors report such a case because of its rarity and to make the mechanism of its appearance clear. The case was a 45-year-old female who was transported to our clinic after the onset of sudden headache. On admission, she had no neurological deficits without severe headache. CT scan revealed subarachnoid hemorrhage, and left carotid angiogram showed an aneurysm at the bifurcation of the left internal carotid artery. On the day of admission, neck clipping for the aneurysm was successfully performed. Postoperative course was uneventful without mild right hemiparesis which diminished until two weeks after operation. Since the 24th day from operation, athetoid involuntary movement occurred to her four toes. 123I-IMP SPECT revealed low perfusion from left frontal base to caudate, and CT scan showed atrophy of the left caudate. Athetoid involuntary movement as postoperative complication of ruptured cerebral aneurysm has not been reported without our case. We suppose it was caused by the ischemic effect of the left caudate due to the operative retraction or the delayed vasospasm after subarachnoid hemorrhage.

Female

[A case of hydrocephalus with hypacusis due to hemangioblastoma].

A case of a brain stem hemangioblastoma with recurrent episodes of hypacusis due to progression of hydrocephalus is reported. The patient was a 25-year-old female, admitted to the department of otorhinolaryngology with complaints of hearing difficulty, headache and blurred vision. Neuroradiological studies showed a tumor from the medulla oblongata, obliterating the IVth ventricle, and a secondary hydrocephalus. Hearing loss fluctuated as hydrocephalus progressed. Multiple V-P shunting procedures relieved episodic hypacusis. The patient remains asymptomatic at present and has resumed normal activity. The mechanism of episodic hearing loss due to hydrocephalus is though to be due to the fact that through the ductus perilymphaticus and the ductus endolymphaticus, especially the former, increased intracranial pressure is transmitted to the inner ear. Through the ductus perilymphaticus there is communication between the perilymphatic space and the intracranial subarachnoid space. Through the ductus endolymphaticus there is communication with the subdural space. Increased ICP effects the inner ear. It is suspected that, in this particular case, the progression of hydrocephalus effected the patient's hearing.

Adult

The finger-tapping test. A quantitative analysis.

A quantitative analysis of the so-called finger-tapping test was performed on 111 normal subjects. Quantitative analysis was also performed on 17 patients with cerebellar diseases, 14 with parkinsonism, and 14 with hemiparesis. All analyses were performed in a simple fashion using an 8-bit microcomputer fed through an electrocardiographic apparatus. The results in normal subjects were as follows: (1) tapping frequency lowered with advancing age; (2) men tapped faster than women; and (3) tapping with the dominant finger was faster than tapping with the nondominant finger in normal subjects. Tapping frequency can distinguish patients with motor dysfunctions of cerebellar, basal ganglia, and cerebral origins from normal subjects. Only the time-sequential histograms of tapping intervals could distinguish the motor dysfunctions studied.

Adult

Effect of pinealectomy on cortically kindled rats.

Cortical kindling in pinealectomized rats was studied to observe the effect of pinealectomy on local afterdischarge thresholds and seizure development. Although the local afterdischarge thresholds were not affected by pinealectomy, the kindling process itself was hastened. These results suggest that the anticonvulsive function of the pineal body is due not to a decrease in local afterdischarge thresholds, but to retardation of secondary generalization.

Animals

Lipoma in the cerebellopontine angle--case report.

The authors report a case of a cerebellopontine (CP) angle lipoma with a very unusual histological appearance. The 38-year-old male patient suffered vertigo, left tinnitus, and left hearing disturbance. Computed tomography and magnetic resonance imaging showed a nonenhanced low-density area and a high-intensity region in the left CP angle, respectively. The tumor, which was only partially removed because of its tight adhesion to the VIIIth nerve and brainstem, consisted of mature lipocytes and contained a piece of cartilage, which is highly unusual.

Adult

[Angiographic findings of vertebral dissecting aneurysm. Report of two cases and review of literature].

The authors report two cases of vertebral dissecting aneurysm. The first case, a 49-year-old female, developed severe headache and computed tomography scan showed subarachnoid hemorrhage (SAH), but 4-vessel cerebral angiography failed to show an aneurysm. The second angiograms obtained 2 weeks later showed possible aneurysmal dilatation on the right vertebral artery. The third angiograms, 2.5 months after SAH, disclosed a right vertebral fusiform aneurysm on the arterial phase and it was diagnosed as a dissecting aneurysm since the contrast medium remained until the very late venous phase. The previous angiograms were reviewed using the subtraction technique, which revealed retention of the contrast medium. The second case, a 42-year-old female, suffered from SAH. Left vertebral angiography revealed a fusiform aneurysmal tapered narrowing just distal to the aneurysm, which was a typical "pearl and string sign." The subtraction film of the venous phase also showed retention of the contrast medium in the aneurysmal portion. These findings accurately diagnosed dissecting aneurysm of the vertebral artery. Since the classical true diagnostic "double lumen sign" was rarely observed in the angiograms, it was not easy to diagnose dissecting aneurysm of the vertebral artery. The authors emphasize the angiographic findings of retention of the contrast medium in the venous phase as a "true diagnostic sign" for correct diagnosis of dissecting aneurysm.

Aortic Dissection

Line-drawing test across ages.

A line-drawing test was standardized for normal subjects to examine effects of normal aging. For this purpose, the results of the test for 168 normal volunteers were quantified using a digitizer and a microcomputer across ages from 9 to 78 yr. Three sets of parallel vertical lines were presented to every subject, the distances between the parallel vertical lines (5, 10, and 15 cm) differed in the three sets. A subject drew an horizontal line starting exactly on the left vertical line and stopped exactly on the right one, and the computer could detect minute inaccuracy at the start and at the stop, which inaccuracy was expressed in mm. In this study, effects of four parameters were evaluated, i.e., ages, sex, distances from the paired vertical lines, and order of trials; all were nonsignificant. The normal range of the deviations was within 2.1 mm (average + 2 SD).

Adolescent

[Unilateral nerve deafness due to rupture of a right vertebral artery aneurysm. Case report].

A 49-year-old female with no history of hearing disturbance developed sudden onset of headache and was admitted with no neurological deficits other than mild nuchal rigidity. Computed tomography (CT) showed subarachnoid hemorrhage. Four-vessel cerebral angiography disclosed no aneurysm. A second angiogram obtained on the 14th day showed vasospasm of the bilateral posterior cerebral arteries and right anterior inferior cerebellar artery, but still failed to demonstrate an aneurysm. Following the second angiography, she developed mild disturbance of consciousness and cerebellar ataxia of the right limbs, and repeat CT showed an infarct in the right cerebellar hemisphere. When she regained consciousness a few days later, she was completely deaf on the right side. The third angiography revealed a right vertebral artery dissecting aneurysm. Following clipping of the proximal portion of the right vertebral artery, she did well and was discharged, although right cerebellar ataxia and deafness persisted. Neuro-otological evaluation, including pure-tone audiography, auditory brainstem responses, electrocochleography, and caloric testing, indicated that her deafness resulted from ischemia in the territory of the right internal auditory artery due to vasospasm.

Deafness

[Significance of "on-off phonation test" to detect oral diadochokinesia in dysarthric patients].

Oral diadochokinetic abilities in 6 patients with ataxic dysarthria (ATAXICs), 6 with spastic dysarthria (SPASTICs), 3 with parkinsonism (PARKINs), and 6 normal subjects (NORMALs) were investigated using repetition of monosyllable /pa/ and "on-off phonation test" in which they had been requested to repeat interrupted vowel /a/ as fast as possible. Oscillographic as well as photographic records of the speech acoustic signal were obtained to analyse interval for a syllable, which consisted of voiced and unvoiced intervals, and peak-value of voiced interval. The results were as follows: 1) ATAXICs and SPASTICs showed prolonged interval for a syllable, yet that of PARKINs was within normal range, when tested either in /a/ or in /pa/. 2) Standard deviation and coefficient of variation for intervals of syllable and those of peak-values in voiced interval could not distinguish their characteristics among ATAXICs, SPASTICs, and PARKINs. 3) In "on-off phonation test", ATAXICs showed prolonged unvoiced intervals, while SPASTICs did prolonged voiced intervals. Results suggested that hypotonic laryngeal muscles in ATAXICs might result in prolongation of unvoiced interval, but that prolonged voiced interval related to biased hypertonus of laryngeal adductor. It is concluded that "on-off phonation test" could, with reasonable sensitivity, reflect the phonatory dynamics of laryngeal muscles in dysarthric patients.

Aged

[Isolated fracture of the lateral mass of the atlas: a case report].

Isolated fracture of the lateral mass of the atlas is extremely rare. The authors report such a case because of its rarity and to emphasize the usefulness of computed tomography (CT) for its diagnosis. The case was that of a 63-year-old male, who had been hit on his left parietal region by a board falling from behind, and which forced him to hyperflex his neck. He complained of neck pain on arrival at our hospital without any resulting neurological deficits. Routine plain cervical spine films were normal, but CT scan revealed a vertical fracture of the lateral mass of the atlas. He was placed in a Halo brace for several months, and after 3 months the fracture was seen, by CT scan, to have healed without complications. Fractures of the atlas are uncommon. They comprise 2-13% of all fractures of the cervical spine, and about 1.3% of the fractures of the entire spinal column. An isolated fracture of the lateral mass of the atlas has been reported only in seven cases including our case previously and this is the first case in which CT scan could make the diagnosis. We emphasize that CT scan is a most useful tool for the diagnosis of the fracture.

Braces

[Trigeminal nerve dysfunction as a false localizing sign: a case of the choroid plexus papilloma in the IVth ventricle].

Trigeminal nerve dysfunction as a false localizing sign, although rate, is known to occur. A case of choroid plexus papilloma in the 4th ventricle with hemifacial numbness is presented. A 24-year-old woman had been suffering from intermittent facial numbness on the left side for 3 months prior to admission. She noted no other symptoms. Neurological examination disclosed marked papilledema, horizontal nystagmus on both lateral gazes and mild truncal ataxia. CT scans showed a calcified mass lesion in the 4th ventricle on the midline extending into the left lateral recess. It was enhanced homogeneously with contrast material. The pathogenesis of such a false localizing sign and its clinical implications were discussed from the anatomical point of view.

Adult

[Clinical study of traumatic cerebellar contusion].

Numerous authors have reported cases of traumatic cerebellar contusion. A few authors have emphasized delayed deteriorations in patients with cerebellar contusion. Since CT scan was introduced into daily clinical practice, it has become obvious that cerebellar contusion were not necessarily associated with severe head injuries. Of 1176 head-injured cases admitted to our department in the past five years, eight (0.7%) were diagnosed by CT scans to have cerebellar contusion. Among eight cases, two of them were deeply comatose on admission because they had concomitant diffuse cerebral contusions and died soon after admission. Remaining six cases had predominantly cerebellar contusion on CT scans and showed minimal neurological deficits on admission. Most of them recovered without any significant disabilities. But two of them deteriorated several hours after injury, showing brain-stem compression for which emergency posterior fossa decompression were carried out without recovery. One of them underwent external decompression which resulted in intracerebellar massive hemorrhage and the other missed the timing of surgery. In conclusion, it is important to prepare for unexpectedly rapid deterioration, for which wide craniectomy and sufficient internal decompression would be required.

Adult