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T Nishijima

Publications and source records attributed to T Nishijima.

14 recordsLinked to original sources
PubMed1992

[Clinical study of terodiline hydrochloride for the treatment of urinary frequency and urinary incontinence, and its cardiovascular adverse effects].

We evaluated the effectiveness and side effects of terodiline hydrochloride in 109 patients with urinary frequency and urinary incontinence. The drug was administered at a dose of 24 mg once a day or 12 mg twice a day for 4 weeks. Symptoms such as urinary frequency and urinary incontinence were alleviated in 101 out of 109 patients (92.7%). Mild side effects such as thirst, dysuria, sense of residual urine, orthostatic hypotension and arrhythmia were observed in 9 out of 109 patients (8.2%). Side effects such as orthostatic hypotension and arrhythmia were observed on the 28th day or the 20th day of the administration, but these symptoms disappeared with discontinued use of this medicine. The results obtained from this study suggest that terodiline hydrochloride may be greatly useful for the patients with urinary frequency and urinary incontinence. But we must take account of the side effects such as orthostatic hypotension and arrhythmia.

Aged↗
PubMed1992

[Study of preventive effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU) or combination of HCFU and 2.5-di-O-acetyl-D-glucaro (1-4) (6-3) dilactone (SLA) after preservative operation against bladder cancer].

To treat superficial bladder cancer or invasive bladder cancer presenting as a solitary tumor, conservative therapy such as transurethral resection of bladder tumor or partial cystectomy has long been carried out. We studied the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), and the effects of the combination of HCFU and 2.5-di-O-acetyl-D-glucaro-(1-4)(6-3) dilactone (SLA) which is an anti-beta-glucuronidase agent, for preventive therapy. In the patients treated with HCFU, the recurrence rate was 3.6% and 26.6% one year and two years, respectively, after conservative operation. In the patients treated with both SLA and HCFU, the recurrence rate was lower than in those treated with HCFU one year or more after conservative operation, and a long-term preventive effect was expected for nondrinkers.

Adult↗
PubMed1992

[Clinical study on 15 cases of torsion of the spermatic cord].

We experienced fifteen cases of torsion of the spermatic cord during the past 10 years. The age distribution was from 10 to 40 years old and the average age was 21.1 years. All cases except one case of right undescended testis occurred on the left side. To our interest, the onset in 12 of the 13 cases with known onset time were during sleep or within one hour after waking up. All cases except one case in the undescended testis complained of pain of the testis and some of them were accompanied with pain in the inguinal and lower abdominal region. Swelling and tenderness of the testis were observed in most cases and shortness of the spermatic cord probably caused by torsion and secondary inflammation seemed to be important findings. Prehn's sign and fever up were observed in few cases but leukocytosis was seen in 10 cases. Eleven cases of surgical treatment consisting of 10 orchiopexy and one orchiectomy were performed. Four cases of spontaneous detorsion were included in our experience. Orchiopexy of the contralateral intact testis was not done, but, we have never experienced relapse of torsion.

Adolescent↗
PubMed1990

Active-site-directed inactivation of Aspergillus oryzae beta-galactosidase with beta-D-galactopyranosylmethyl-p-nitrophenyltriazene.

beta-D-Galactopyranosylmethyl-p-nitrophenyltriazene (beta-GalMNT), a specific inhibitor of beta-galactosidase, was isolated as crystals by HPLC and its chemical and physicochemical characteristics were examined. Aspergillus oryzae beta-galactosidase was inactivated by the compound. We studied the inhibition mechanism in detail. The inhibitor was hydrolyzed by the enzyme to p-nitroaniline and an active intermediate (beta-galactopyranosylmethyl carbonium or beta-galactopyranosylmethyldiazonium), which inactivated the enzyme. The efficiency of inactivation of the enzyme (the ratio of moles of inactivated enzyme to moles of beta-GalMNT hydrolyzed by the enzyme) was 3%; the efficiency of Escherichia coli beta-galactosidase was 49%. In spite of the low efficiency, the rate of inactivation of A. oryzae enzyme was not very different from that of the E. coli enzyme, because the former hydrolyzed beta-GalMNT faster than the latter did. A. oryzae beta-galactosidase was also inactivated by p-chlorophenyl, p-tolyl, and m-nitrophenyl derivatives of beta-galactopyranosylmethyltriazene. However, E. coli beta-galactosidase was not inactivated by these triazene derivatives. The results showed that the inactivation of A. oryzae and E. coli beta-galactosidases by beta-GalMNT was an enzyme-activated and active-site-directed irreversible inactivation. The possibility of inactivation by intermediates produced nonenzymatically was ruled out for E. coli, but not for the A. oryzae enzyme.

Aspergillus↗
PubMed1990

Restorative effects of thymosin fraction 5 on reduction in responsiveness of rat thymocytes to allogenic lymphocytes during bladder tumor induction.

One-way MLR was examined by using thymocytes (responder) from Fischer 344/NSIc rats in which urinary bladder cancers were induced by administration of N-butyl-N-(4-hydroxybutyl)nitrosamine [(BBN) CAS: 3817-11-6], and lymph node lymphocytes (stimulator) from WKH/Hkm rats. From the 10th week of the administration, when only hyperplastic change was noticed in the bladder mucosa, progressive decrease of the MLR was detected in the thymus small lymphocyte population (TSLP) and the decrease was the most conspicuous in more dense, namely, intermediate and heavier, small lymphocyte subpopulations. When TSLP was pretreated with TF5 in vitro, the most restorative effects on the decreased MLR were found in hyperplastic stage and the effects were becoming less with the advance of tumor developments. Moreover, in scrutinizing the effects of TF5 on the small lymphocyte subpopulation in hyperplastic stage, the maximal restoration of the responsiveness was found in the heavier subpopulation.

Animals↗
PubMed1979

Studies of the nonspecific cellular immune response in patients with urinary bladder carcinoma. I. PHA-induced lymphocyte transformation.

The nonspecific cellular immune response, as measured by phytohemagglutinin (PHA)-induced blastoid transformation of peripheral lymphocytes in autologous serum, was evaluated in 119 patients with bladder carcinoma and in 21 control subjects. Blastoid transformation was determined by quantifying 3H-thymidine incorporation (counts per minute). The rate of blastogenesis of lymphocytes was shown as the stimulation index which was calculated by dividing the number of counts per minute with PHA by that without PHA. The stimulation index of the control subjects was 29.9 +/- 6.6 (+/- SD); that of the experimental group was 13.3 +/- 7 (significantly lower reactivity). There was a converse correlation between the stimulation index and the grade and stage of tumor. In some cases the change in cellular immunity was compared before and after surgery.

Adult↗
PubMed1979

Studies of the nonspecific cellular immune response in patients with urinary bladder carcinoma. II. Immunodepressive effect of sera from bladder carcinoma.

In vitro reactivity of normal lymphocytes in various sera was determined by quantitation of phytohemagglutinin (PHA)-induced tritiated thymidine incorporation rate (counts per minute). Sera were obtained from normal subjects, fetal calf, and patients with bladder carcinoma. The rate of lymphocyte blastogenesis was expressed as a stimulation index (SI) that was calculated by dividing the number of counts per minute with PHA by that without PHA. The effect of sera on blastogenesis of normal lymphocytes was expressed as percent change (%SI) per SI with fetal calf serum. The SI of normal lymphocytes was similar in autologous serum (26.7 +/- 11.6), fetal calf serum (25.4 +/- 11.8), and heat-inactivated homologous normal AB serum (28.8 +/- 11.4). The SI of normal lymphocytes in sera from patients with bladder carcinoma was significantly lower than in the other two sera (14.0 +/- 7.9). The serum inhibitory effect was significantly associated with the stage and grade of tumor and was diminished after removal of the tumor. The SI of lymphocytes from patients with certain other malignant diseases was significantly lower in autologous serum than in fetal calf serum or homologous normal AB serum. The SI of the lymphocytes from patients with prostatic carcinoma and embryonal cell carcinoma was also low in sera from patients with bladder carcinoma as well as in autologous sera. It is likely that the depressive effect of sera from patients with bladder carcinoma was not specific to bladder carcinoma.

Blood↗
PubMed1977

[Clinical study of carfecillin in chronic urinary tract infection (author's transl)].

1. Ten patients with chronic urinary tract infection by Pseudomonas aeruginosa or Proteus species were treated with carfecillin. Excellent response was seen in one case, fairly good in 5 cases and clinical effective rate was 60%. 2. The recurrence suppression effect of carfecillin was examined in two patients suffering from complicated urinary tract infection. In both cases, recurrence was not found when carfecillin was administered for a week after the effective pretreatment of carbenicillin, but found when administered for two weeks. 3. Side effects were observed in 3 cases (itching, tinnitus, diarrhea).

Aged↗