Use of a protease-modulating matrix dressing on a non-healing tendo-Achilles surgical wound.
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Achilles Tendon↗
Biomedical subjects
T Noble
Publications and source records attributed to T Noble.
The routine six week postnatal vaginal examination.
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Female↗
Determinants of benzodiazepine prescribing and administration in a public hospital.
There is increasing concern with problems of benzodiazepine dependence resulting from long-term use of these drugs. Recent studies have shown that hospitalized patients are frequently prescribed benzodiazepines, often on a short-term basis, but sometimes with discharge prescriptions which may lead to more prolonged use. The present study investigated the factors affecting whether or not a patient was prescribed and administered a benzodiazepine in a public hospital. Patients from a range of medical and surgical wards were assessed to determine their normal sleeping patterns and sleeping patterns during their stay in hospital. Levels of anxiety were also measured. Rates of use were high, with 77% of the sample being prescribed a benzodiazepine and 52% of the whole group receiving the drug on at least one occasion. Age, sex, occupation, and marital status were not significantly associated with prescription or administration. Similarly, anxiety levels before and during admission did not predict usage. However, those prescribed and those actually administered the drug had significantly poorer sleep patterns. The high rate of use of benzodiazepines in this hospital appears to be a response to self-reported sleep difficulties.
Adolescent↗
Symptom relief with moderate dose chemotherapy (mitomycin-C, vinblastine and cisplatin) in advanced non-small cell lung cancer.
Twenty-four symptomatic patients with advanced non-small cell lung cancer (NSCLC) were treated with cisplatin-based chemotherapy (mitomycin-C 8 mg m-2 q 6 weeks, vinblastine 6 mg m-2 q 3 weeks, cisplatin 50 mg m-2 q 3 weeks). Patients were assessed for symptom relief as well as for objective response. Although only five patients achieved an objective response (21%), 18 patients (75%) reported a complete disappearance or good improvement in at least one of their tumour-related symptoms. The overall symptomatic response rate was 67% with 16 patients feeling better or much better on treatment. The toxicity of treatment (primarily myelosuppression and nausea and vomiting) was mild and hair loss was minimal. The high incidence of symptomatic relief seen in this study, even in the absence of objective response, suggests that moderate dose chemotherapy may have a role in the palliation of NSCLC.
Adult↗