Biomedical subjects

T Nukada

Publications and source records attributed to T Nukada.

At least 73 records · Page 4Linked to original sources

PubMed1982

The use of labetalol in Japan: results of multicentre clinical trials.

1 The anti-hypertensive effects and safety of labetalol have been evaluated in multicentre clinical trials in Japan based on unified study protocols. The results of three studies are reported. 2 A total of 178 patients with essential hypertension were treated with labetalol for 12 weeks, 127 of them with labetalol alone (monotherapy) and the other 51 with labetalol plus diuretics (combined therapy). 3 Satisfactory antihypertensive effects were achieved in 76 of the 119 assessable patients in the monotherapy group and 25 of the 49 in the combined therapy group. The mean daily doses of labetalol were 329 mg in the monotherapy group and 374 mg in the combined therapy group. Seven patients (six in the monotherapy group; one in the combined therapy group) were withdrawn from the trials due to side-effects. 4 Sixty-one patients with hypertension were treated with labetalol alone or combined with diuretics for 6 months or longer. In most of these patients, good blood pressure control was achieved. No patients had to discontinue the treatment due to side-effects. The mean daily doses of labetalol were stabilised in and after week 8 of the treatment at an average of 260 mg in the monotherapy and 450 mg in the combined therapy. Tolerance to the anti-hypertensive effect did not develop. 5 Thirty patients with phaeochromocytoma were treated with labetalol and good blood pressure control was achieved in 21 of them. The effects of labetalol were better in patients with predominantly adrenaline-secreting tumours, and better in patients with sustained hypertensive type than in those with paroxysmal hypertensive type.

Adult↗

PubMed1981

Ultrasonic Doppler studies after superficial temporal-middle cerebral artery anastomosis.

The ultrasonic Doppler technique was applied to evaluate the effect of STA-MCA anastomosis. Not only the STA itself, but also ophthalmic and major aortocranial arteries were recorded by the Doppler technique in 12 patients who had undergone STA-MCA anastomosis for internal carotid artery occlusion or stenosis. The examination was performed before, and within a month after the operation. The blood flow pattern of the STA, which had had an external carotid flow pattern, was altered to an internal carotid flow pattern by the STA-MCA bypass operation. The findings of Doppler sonograms of the STA were exactly consistent with post-operative angiograms and precisely represented the bypass patency. Among 7 patients with reverse flow direction in the ophthalmic artery before the operation, the reverse flow had decreased in 5 patients post-operatively. But no remarkable change in the ophthalmic artery was detected in the remaining 2 patients. The blood flow velocity patterns of major aortocranial arteries showed no change post-operatively.

Blood Flow Velocity↗

PubMed1981

Internal carotid occlusion: assessment, by Tc-99m-tagged microspheres, of bypass from superficial temporal to middle cerebral artery.

The assessment of regional blood perfusion through the STA-MCA anastomosis was performed by the method of intracarotid injection of Tc-99m-labeled human albumin microspheres (HAM scintigraphy). This study included 11 anastomoses in 10 cases with occlusion of the internal carotid artery, who were treated by bypass surgery. The area of intracranial perfusion through the bypass was well defined in all cases by HAM scintigraphy. This method is excellent for imaging the regional blood perfusion through the anastomotic vessel, and the scintigraphic findings agree well with those of postoperative angiography. HAM scintigraphy will partially replace postoperative angiography because of its simplicity and low invasiveness.

Adult↗

PubMed1980

Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin.

The ability of platelets to synthesize thromboxane B2 (TxB2) from arachidonic acid (AA) or prostaglandin H2 (PGH2) was studied in 26 control subjects, 40 patients with essential hypertension, 20 patients with cerebrovascular disease (CVD) not taking aspirin and 11 patients with CVD taking aspirin. The activity of platelets to form TxB2 from AA or PGH2 was measured using 1-14C arachidonic acid or 1-14C PGH2 as a substrate. There was no significant difference in TxB2 generation from AA or PGH2 among the platelets collected from the control subjects, hypertensive patients and CVD patients not taking aspirin. In CVD patients taking aspirin, marked suppression was observed in TxB2 synthesis from AA, but no suppression in TxB2 synthesis from PGH2. At least 750 mg aspirin per day were required for nearly complete suppression of TxB2 generation from AA.

Adolescent↗

PubMed1980

Behcet's disease with sinus thrombosis and arteriovenous malformation in brain.

A 55-year-old man suffered from Behcet's disease with bilateral sigmoid sinus thrombosis and dural arteriovenous malformation has been studied clinically and pathologically. A possible causal relationship between Behcet's disease and sigmoid sinus thrombosis is discussed.

Behcet Syndrome↗

PubMed1980

Hemodynamic and volume characteristics, and peripheral plasma renin activity in Takayasu's arteritis.

Hemodynamic and volume characteristics, and/or peripheral plasma renin activity were investigated in 19 patients with Takayasu's arteritis who included 8 hypertensive patients with renal arterial disease and 11 normotensive patients. In hypertensive patients, mean arterial pressure had an inverse correlation with cardiac index, a direct correlation with total peripheral resistance index and no correlation with blood volume. These hemodynamic and volume characteristics were different from those of hypertension with renal arterial disease previously reported. High plasma renin activity was presented in not only hypertensive patients with renal arterial disease but normotensive patients. The investigation of high plasma renin activity in Takayasu's arteritis must be also directed to the mechanism except renal arterial lesions.

Adolescent↗

PubMed1980