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Biomedical subjects

T O Cole

Publications and source records attributed to T O Cole.

16 recordsLinked to original sources
PubMed1991

Electrocardiographic hypertrophic patterns in hypertensive Nigerians.

We studied hypertrophic patterns in the electrocardiograms of 60 Nigerian hypertensives. Thirty were in heart failure and 30 without failure (matched for age and sex). Combined left ventricular and left atrial hypertrophy was the commonest finding occurring in 58.3%, followed by left ventricular hypertrophy alone in 30%. 76.7% and 40% had combined left ventricular and left atrial hypertrophy in the heart failure and the non-heart failure groups, respectively (P less than 0.02). Though these changes increased with increased blood pressure, the latter is similarly severe in both groups. 100% of patients in Class IV failure had combined left ventricular and left atrial hypertrophy. The 3 patients who had additional right atrial hypertrophy were in Class IV failure, 2 of whom died during follow-up. These changes are much more marked at presentation than reprots in caucasians and even in previous reports in Africans. The changes reflect the long-standing nature and severity of the hypertensive process, and point to the fact that the majority of hypertensives in this environment present rather late.

Adult↗
PubMed1990

Drug compliance in hypertensive Nigerians with and without heart failure.

We assessed and evaluated drug compliance and the factors militating against good compliance in 68 hypertensive Nigerians with and without heart failure. Of our patients who were detected to have high blood pressure for some years previously, 59.5% were not informed by their physicians of the need for continued and regular treatment and follow-up; 21.6% were informed but could not keep to regular medication and follow up purely due to economic constraints; 18.9% were informed and yet did not keep to regular medication due to reasons such as alternative medical treatment, frustrations with daily ingestion of drugs, or a feeling of well-being. Drug compliance was poor in all socio-economic classes. Following intervention through health education on the consequences of poorly managed hypertension, and the involvement of the Medical Social Workers in the management of defaulters, the drug compliance markedly improved. The results show that ignorance seems to be the major factor militating against proper control of blood pressure in our hypertensives, and not economic constraint.

Adult↗
PubMed1977

Alternating left anterior hemiblock without associated tachycardia.

This case report describes a 64-year-old woman with a cardiomyopathy and associated fascicular conduction disturbances partly related to digitalis therapy. Electrocardiograms showed incomplete left bundle branch block with left anterior hemiblock the latter, consistently changing in pattern and rhythm as in bidirectional tachycardia but at a relatively normal heart rate. The relationship of severe myocardial disease to the apparent likelihood of pre-existing depression of fascicular conduction in cases of bidirectional tachycardia precipitated by digitalis, is exemplified.

Bundle-Branch Block↗
PubMed1976

Relationship of serum copper and zinc to human hypertension in Nigerians.

Serum copper and zinc levels were determined by atomic absorption spectroscopy in 48 hypertensive Nigerians and in 37 normotensive controls. Serum copper and total cholesterol levels were significantly increased in the hypertensive patients, but their serum zinc levels did not differ from those of the controls.

Adult↗
PubMed1975

Fascicular conduction blocks and their relationship to complete heart block in Nigerians.

Following electrocardiographic analysis, isolated or combined blocks in the intraventricular trifascicular system including predivisional left bundle branch block with left posterior hemiblock in Nigerians are presented and the underlying causes reviewed. The rarity of complete heart block, despite the not uncommon fascicular blocks, is of interest and may be related to the population age structure considering the invariably slow rate of degeneration of conduction fibres in the system.

Adolescent↗
PubMedDate not supplied

Early onset and significance of imcomplete left posterior hemiblock in Nigerians.

Following detailed clinical and electrocardiographic analysis, twenty-five patients with incomplete left posterior hemiblock without associated complete right or left bundle branch block are presented. First-degree atrioventricular block was relatively common in these patients and associated incomplete right or left bundle branch block was also present in a few. Hypertension was the commonest underlying cardiovascular disease but two of them, without any clinically overt cardiovascular disease, presented with a history of episodic dizziness or syncopal attacks. With the present knowledge of the anatomy and histopathology of intraventricular conduction system, the relevance of tendency for Africans to form excessive fibrous tissue has been emphasized. Considering the unexpectedly low average age of these patients, suggestions have been made with a view to reducing the rate of progression of such atrioventricular conduction defects to the need for implanted cardiac pacemakers.

Adult↗