Complete allelic analysis of BRCA1 and BRCA2 variants in young Nigerian breast cancer patients.
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Biomedical subjects
Publications and source records attributed to T O Ogundiran.
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Necrotizing fasciitis (NF) is a rare but rapidly progressive and potentially fatal disease condition. It is characterized by progressive inflammation and extensive necrosis of the subcutaneous tissue and fascia, sparing the underlying tissue. It is a poly-bacterial infection and is associated with profound systemic toxicity, considerable morbidity and a high mortality rate. The outcome is influenced by early recognition and radical surgical debridement. We present a report of six cases of NF who presented to our surgical service within the past 5 years.
A case of spontaneous rupture of an incisional hernia is hereby presented. Though very rare in adults, it is a potentially fatal but preventable clinical condition.
Beckwith-Wiedemann Syndrome (BWS), also known as the EMG (Exomphalos, Macroglossia, Gigantism) syndrome was recognised independently by Beckwith in 1963 and Wiedemann in 1964 and is now a well established entity having been reported in more than two hundred individuals. It constitutes a wide spectrum of clinicopathologic entity with varied combinations of congenital and time dependent abnormalities that often make diagnosis and management tasking. There is paucity of report in the literature on this entity from the developing world. We present a case recently seen at the University College Hospital (UCH) Ibadan, Nigeria in order to create further awareness and highlight peculiarity of management as may be applicable in a setting as ours.
A retrospective review of 232 patients with (mechanical) instestinal obstruction managed at the University College Hospital, Ibadan over a ten-year period: 1978 to 1987. The leading aetiological factor was obstructed inguinal hernia (45.7%), although its incidence seems to be on the decline. Ileo-colic type instussusception was the most prevalent variety (62.8%) with preponderance of the paediatric age group. There is an observed increase in the proportion of obstruction due to tumours. Ascaris infestation is no longer a prominent aetiological factor. One third of the 8.2% mortality rate observed was in neonates.