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Biomedical subjects

T Ohmoto

Publications and source records attributed to T Ohmoto.

At least 271 records · Page 15Linked to original sources
PubMed1987

Experimental study on resting tremor and L-dopa-induced dyskinesia.

Resting tremor and hypokinesia of unilateral limbs were produced in monkeys after making a lesion in the mesencephalic tegmentum. The administration of L-dopa or dopamine agonists relieved them and followingly induced dyskinesias. The same effects were produced by the direct injection of dopamine or its agonists into the dorsomedial part of caudate nucleus ipsilateral to the lesion, where spiroperidol binding to the D2 receptor was increased in the affinity. These results suggest that denervation supersensitivity at the postsynaptic D2 receptor is a basic condition for the development of dyskinesias, though they were slightly suppressed by the intracaudate injection of GABA, serotonin and met-enkephalin.

Animals↗
PubMed1987

Decreased dopamine level in the epileptic focus.

Catecholamine and serotonin in the focus tissues of 12 intractable epileptic patients who underwent surgery were analysed by high performance liquid chromatography with electrochemical detection, and it was found that dopamine contents in epileptic foci were clearly lower than in surrounding tissue in 7 of the 12 epileptics examined. In the other 5 patients, dopamine levels were much lower than in non-convulsive neuropathic patients.

Adolescent↗
PubMed1985

Combined trigeminal and glossopharyngeal neuralgia.

A case of combined trigeminal and glossopharyngeal neuralgia is described. The superior cerebellar artery and normal choroid plexus compressed and indented the root entry zones of the trigeminal and glossopharyngeal nerves, respectively. Complete relief was obtained after microvascular decompression and resection of the choroid plexus.

Arteries↗
PubMed1984

Inhibition of nociceptive neurons by internal capsule stimulation.

The mechanism of pain relief by internal capsule (IC) stimulation was investigated in 32 adult cats. Nociceptive neuronal activity of the nucleus ventralis posteromedialis (VPM), responding to contralateral pulp stimulation, was suppressed by IC stimulation to a greater extent than activity in the posterior nuclear group (PO) or centre-median nucleus. On the contrary, suppression of neuronal firing by intraventricular morphine-HCl predominated in PO neurons. These results suggest that pain relief by IC stimulation may be mediated through inhibitory effects on nociceptive neurons of the thalamic sensory relay nuclei.

Analgesia↗
PubMed1984

Electrical stimulation of the posterior limb of the internal capsule for treatment of thalamic pain.

Electrical stimulation of the posterior limb of the internal capsule was performed in 7 patients with thalamic pain who had developed dysesthesia, hyperpathia and/or spontaneous burning pain. Ramped bipolar stimulation elicited sensory responses, such as warm or comfortable sensation. Follow-up from 9 months to 2 years and 7 months showed that 3 patients had a good result, two had fair and the remaining two had poor results. No serious side effects were seen. The mechanism of pain relief by the internal capsule stimulation is discussed.

Afferent Pathways↗