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T Ohnaka

Publications and source records attributed to T Ohnaka.

51 records · Page 3Linked to original sources
PubMed1985

Nucleolus-associated localization of J chains in IgG 1(lambda)-producing myeloma cells.

By using both direct and indirect immunofluorescence technics and the PAP method, the authors observed an unusual immunocytochemical staining pattern in myeloma cells producing IgG 1(lambda). J chains were localized mainly as intranuclear spots, compared with gamma and lambda chains that are diffusely distributed in the cytoplasm with dense perinuclear accumulation. The present findings on the location, size, and number of the intranuclear spots suggest that J chains are nucleolus associated. The authors hypothesize that J chains are synthesized in the cytoplasm and transported into the nucleolus, where they associate with nucleolar proteins, or that they are synthesized within the nucleolus, which participates in biogenesis of ribosomes.

Bone Marrow↗
PubMed1981

Meningeal involvement in multiple myeloma.

Meningeal involvement in multiple myeloma is a rare occurrence. We report a case of IgG myeloma with neoplastic cell infiltration into the cerebrospinal fluid as determined by a protein A plaque-forming cell assay. Electrophoresis of the cerebrospinal fluid revealed a monoclonal band in the same position as the monoclonal band in the serum. Meningeal involvement may probably be more common at the terminal stage in multiple myeloma than has been previously considered.

Cerebrospinal Fluid↗
PubMed1981

[Effects on the manual function of men wearing cold-protective clothing to cold stress (author's transl)].

Subjects were exposed in a climatic chamber for 60 min to air temperature at -5 degrees C, -20 degrees C and -30 degrees C wearing cold-protective clothing. The following manual functions were studied as a function of air temperature, upper limb skin temperatures, mean skin temperatures or mean body temperatures: handgrip strength, pinch strength, bolt-removing task and counting task. The decline of skin temperatures was observed during cold exposure, wearing cold-protective clothing. At 60 min of cold exposure to air temperatures at -5 degrees C, -20 degrees C and -30 degrees C, mean skin temperatures were 30.2 degrees C, 27.8 degrees C and 26.5 degrees C respectively, then II-right-finger skin temperatures were 20.7 degrees C, 13.1 degrees C and 11.8 degrees C respectively. There were reductions only on limited number of manual functions as compared with functions under normal conditions, that is, bolt-removing task and handgrip strength did not significantly change during cold exposure, whereas pinch strength and counting task decreased with lower surface temperatures and body temperatures. Body or surface cooling resulted in reductions in pinch strength by the order of 50%. The rising of the body storage index, which was calculated from the change of the mean body temperature, resulted in a linear decrease in counting task. The capacity to perform manual handling task and muscle strength appeared to vary according to the muscle used for these performance and depending on the levels of cold stress. Body cooling, combined with local upper limb cooling, produced the largest performance decrements.

Adult↗