OBJECTIVE: The MR findings of two cases of subperiosteal hematoma of the orbit are described. MATERIALS AND METHODS: We present two cases of subperiosteal hematoma of the orbit following minor head trauma, the first presenting with chronic progressive exophthalmos and the second with acute proptosis. RESULTS: Both cases showed a well-defined biconvex mass with a curvilinear hypointense band in the superior portion of the orbit. In Case 1 chronic hematoma demonstrated high signal on both T1- and T2-weighted imaging, and in Case 2 acute hematoma displayed intermediate signal on T1-weighted imaging and high signal on T2-weighted imaging. Follow-up MRI in Case 2 demonstrated the typical signal changes from acute to subacute hematoma. CONCLUSION: Subperiosteal hematoma has a characteristic appearance on MRI which is virtually diagnostic. In proper clinical settings MRI is the modality of choice for the detection and characterization of this hematoma.

Child↗

PubMedDate not supplied

Immunopharmacological profile of TEI-3096: a new immunomodulator.

TEI-3096 [6-p-chlorobenzyl-5H-2,3,6,7-terahydro-5,7-dioxothiazolo (3,2-a) pyrimidine], a novel thiazolopyrimidine compound has been shown to suppress adjuvant arthritis in rats without any effect on conventional inflammation. We examined the immuno-pharmacological profile of TEI-3096 in murine lymphocytes. The blastformation induced by Con A or LPS was inhibited by addition of 50-500 microM concentrations of TEI-3096. This compound suppressed elevated plaque-forming cell (PFC) response against T cell-dependent antigen. However, TEI-3096 had no effect either on normal PFC response or on antibody formation against T cell independent antigen. Although orally administered TEI-3096 had no obvious effect on anti-SRBC PFC response in normal mice, it normalized the colchicine-induced enhancement of antibody formation against TNP-HGG. TEI-3096 also enhanced the delayed type hypersensitivity in mice and rats. These results suggests that TEI-3096 restores the abnormal immune response. Therefore, it may be useful for the treatment of auto-immune disease such as rheumatoid arthritis.

Adjuvants, Immunologic↗

PubMedDate not supplied

Intraocular lesions in patients with systemic disease: findings on MR imaging.

Twenty-one intraocular lesions associated with various systemic diseases in 15 patients were studied by MR imaging. The disorders included diabetes mellitus, cardiovascular disease, Behçet disease, sarcoidosis, and ankylosing spondylitis. MR was performed on a 0.5-T system using a surface-coil technique. Ophthalmoscopic visualization of the fundus was precluded by the presence of opaque media in all cases. MR was found to be effective in demonstrating intraocular bleeding, vitreous opacity, detached lesions of the posterior pole, and eyeball deformity. Surface-coil MR is a useful adjunct in the evaluation of the eyes affected by systemic diseases, especially in patients with opaque media.

Adult↗