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Biomedical subjects

T Orłowski

Publications and source records attributed to T Orłowski.

At least 37 records · Page 2Linked to original sources
PubMed1986

The influence of the H-2 receptor antagonist ranitidine on cadaver kidney allograft function.

To assess the influence of ranitidine on kidney allograft function a double-blind, placebo-controlled clinical study in 42 cadaver kidney recipients has been performed. Patients received ranitidine or placebo for 1 month. Four years after transplantation 81% of the patients in the control group were alive; 67% in the control and 71% in the ranitidine group with functioning grafts. These differences were statistically not significant. However, a slightly more intensive steroid therapy was given to keep the ranitidine patients adequately immunosuppressed. Ranitidine thus can be safely used in kidney graft recipients. Because of a lack of gastrointestinal complications in both groups, no conclusions can be drawn regarding the prophylactic value of ranitidine.

Adolescent↗
PubMed1985

Evaluation of immunity of sheep after splenectomy, splenic artery ligation and autotransplantation of splenic tissue.

The studies aiming at evaluation of immunity after splenectomy, splenic artery ligation, and autotransplantation of splenic tissue were performed in sheep. It was found that splenectomy alters both humoral and cellular immunity. The phagocytic activity of granulocytes, reduced level of IgG, drop in T and ARF cells as well as bone marrow stimulation were noted. In animals subjected to splenic artery ligation or autotransplantation of splenic tissue no significant differences in parameters studied were observed. These results correlated with histological examinations indicate that in the case of spleen trauma two important steps should be followed: the spleen, if possible, should be saved or a spleen saving procedure should be employed; in case of extensive trauma or if contraindications for spleen saving exist, autotransplantation of splenic tissue should be performed.

Animals↗
PubMed1983

The comparison of antibody-dependent (ADCC) and lectin-induced (LICC) cytotoxic activities of human blood lymphocytes in healthy and diseased subjects.

Antibody-dependent and PHA-induced cytotoxicity of peripheral blood lymphocytes in healthy human subjects and in patients with primary glomerulopathies (non-treated and on immunosuppressive treatment) as well as hemodialyzed and transplanted patients were investigated. Heavy disorders of ADCC and LICC activity in the groups of uremic patients and in patients on immunosuppressive therapy were found. Higher sensitivity to immunosuppressive treatment demonstrated that the lymphocytes exerted an antibody-dependent rather than a PHA-induced cytotoxicity. Results presented suggested the participation of two different lymphocyte subpopulations with ADCC and LICC activity in the regulatory and pathological processes.

Antibody-Dependent Cell Cytotoxicity↗