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Biomedical subjects

T Orlowski

Publications and source records attributed to T Orlowski.

At least 37 records · Page 2Linked to original sources
PubMed1983

A 2.5-year follow-up of local immunotherapy of advanced stomach and intestinal adenocarcinoma with Propionibacterium granulosum.

Intratumoral injections of 10 mg cells walls from Propionibacterium granulosum strain KP-45 (PG) were applied in 14 patients with advanced, metastatic stomach (five cases) and colorectal (nine cases) adenocarcinoma. Each patient had his own "twin" control. All patients received no other anticancer treatment, except analgetics and/or palliative surgery. Treatment with PG resulted in partial regression of tumors accompanied by improvement of the clinical state of these patients as well as the reappearance of normal values in blood count biochemical parameters. In each pair of twin cases, survival of the PG-treated patient was longer than the untreated control. The mean survival of PG-treated patients was 23.5 months (4 of 14 patients being still alive after 2.5 years follow-up), while all control patients died with a mean survival period of 6.4 months. The difference between these two patient groups of about 17 months is significant (p greater than 0.01).

Adenocarcinoma↗
PubMed1982

Mezlocillin and carbenicillin: a clinical comparison of serious systemic infections in surgical patients.

Eighty patients suffering from severe cases of systemic surgical infections were enrolled in a prospective, controlled randomized study to compare mezlocillin and carbenicillin. The daily dosage was chosen according to international recommendation, i.e. 4 g mezlocillin 6-hourly and 5 g carbenicillin 4-hourly. A clinical, bacteriological and combined "overall" evaluation was made. There was a distinct trend in favour of the mezlocillin group which was not statistically significant. The treatment was well tolerated; no side-effects were observed.

Adult↗
PubMed1982

Mezlocillin in serious surgical infections caused by carbenicillin-resistant bacteria.

Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980. At the end of therapy, the infection had been eliminated in 52 patients; they were cured. The remaining six did not need any additional antibacterial treatment. Sixty-two of the bacterial strains isolated had been eliminated, seven markedly reduced in number and three persisted. No development of resistance or side-effects was observed. A randomized comparative study was conducted at the same time.

Adult↗
PubMed1982

Mechanisms of development of shot wounds caused by missiles of different initial velocity.

The investigation were carried out on blocks of 20% gelatin. Some of these models contained bones. Shots were fired from a distance of 100 m using bullets of 7.62 mm calibre and 715 m/sec initial velocity and bullets 5.52 mm of about 990 m/sec initial velocity. The illuminated gelatin block was filmed at the time of bullet impact at a rate of 9000 frames/sec. The pressure in the block during passage of the bullet was measured, and the decrease of bullet velocity and kinetic energy per 1 cm of the bullet canal was calculated. The character and size of injury to the block were estimated. After shots with bullets of high velocity following changes were seen as compared to those following the impact of bullets of lower initial velocity; the mean rate of bullet canal widened and the size of the temporary cavity was greater, the cavity decay was longer, and the disturbances in the model persisted longer, the pressure in the blocks reached higher values, the bullet velocity decreased, the diameters of exit wounds and depth of fissures in the blocks were greater, the fissure in the hit bone appeared earlier, the bone fragments were pushed apart at a greater distance and their reapproachment was delayed. The shot through the bone in the block changed all these parameters, and in some cases it produced the phenomenon of three-bubbles development of the temporary cavity. The temporary and permanent changes in the block depended on the mode of bullet impact. Temporary cavity pulsation developed when air was trapped within the block. Bullets of high initial velocity convey their kinetic energy to the hit object through a much greater absolute loss of its velocity producing thus a much greater injury, especially in the second half of the bullet canal, with longer lasting and more extensive temporary changes, and greater permanent changes than in the case of wounds produced with bullets of lower initial velocity.

Animals↗
PubMed1982

Effect of missile velocity on the pathophysiology of injuries.

The investigations were carried out on sheep weighing 55 kg on the average. Under general anaesthesia both hind legs were shot through from a distance of 15 m separately with missiles of high or medium initial velocity. For producing haemorrhagic shock in some animals rapid bloodletting was done with removal of 45% of the circulating blood volume. At definite time intervals the serum levels of adrenaline, noradrenaline, glucose, free fatty acids and insulin were determined in the arterial blood. The heart rate, pressure in the aorta and central venous pressure were measured. Following shots with high velocity missiles the observations were as follows: 1) signs of shock appeared earlier and were more dramatic, 2) the extent of exit wound was on the average threefold as large, 3) haemodynamic disturbances developed earlier, increased more sharply and were much greater, 4) the rise of catecholamines level was much more violent reaching many times higher values and persisting longer, 5) changes or glucose, insulin, free fatty acids and insulin were much more pronounced, developed earlier, and regressed after a longer time than after injuries caused by missiles of medium initial velocity.

Animals↗
PubMed1982

[Local immunomodulation in advanced Crohn disease with a cell-wall preparation of Propionibacterium granulosum KP-45].

Four patients aged 30-34 years with Crohn's disease in and advanced stage, having lasted 2 or 3 years, were treated by several injections of 10mg lyophilized cell wall material of P. granulosum strain KP-45 locally into the lesion. In all 4 cases a preceding conventional therapy with Salazopyrine and Prednisone or surgery had been unsuccessful. This local immunomodulatory treatment led to decisive improvement of the disease in all 4 cases, in 3 cases inflammatory symptoms disappeared completely. For this reason a local immunomodulation with P. granulosum KP-45 is recommended as an additional therapeutic procedure in patients who are otherwise resistant to therapy.

Adult↗
PubMed1979

Colony-stimulating factor production and secretion following renal transplantation.

Colony-Stimulating Factor (CSF) production by peripheral blood leukocytes of renal transplant recipients was assayed using semisolid agar culture. Patients with stable graft function had a normal ability to produce CSF and they reacted with an increase of CSF release following bacterial infection, while active viral infections impaired the process. A marked decrease of CSF production was detectable in kidney graft recipients undergoing acute rejection, a phenomenon sometimes reversible by bolus prednisolone administration. Less characteristic patterns of CSF secretion in urine were found in these patients.

Bacterial Infections↗