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Biomedical subjects

T P Fitzjohn

Publications and source records attributed to T P Fitzjohn.

5 recordsLinked to original sources
PubMed1992

Combined pathological and radiological study of the effect of atherosclerosis on the ostia of segmental branches of the abdominal aorta.

A combined pathological and radiological study of descending aortae from 15 subjects from 2 to 80 yrs of age was conducted to investigate changes in the segmental vessels with advancing aortic atherosclerosis. There were (i) small hillocks of musculo-elastic intimal thickening adjacent to the apex (centre of the flow divider) in the ostia of the segmental vessels in young subjects, (ii) progressive intimal thickening, distortion and narrowing of the ostia of the segmental vessels (iii) obliteration or loss of some ostia in advanced atherosclerosis of the distal abdominal aorta and (iv) gross discrepancy in severity of atherosclerosis between the aorta and its branches, the intimal proliferation tapering rapidly in the branches and often being minimal in the outer part of their intramural courses. Distal ramifications exhibited occlusions which radiographically were probably embolic or possibly artifactual. Atherosclerosis was rarely of significant degree histologically within the proximal 2 cm of the segmental branches.

Adolescent↗
PubMed1987

Cervical myelopathy, ossification of the posterior longitudinal ligament, and diffuse idiopathic skeletal hyperostosis: problems in investigation.

This report describes a patient presenting with a spastic quadriplegia who was found to have both diffuse idiopathic skeletal hyperostosis (DISH) and ossification of the posterior longitudinal ligament (OPLL) in the cervical spine. There was a dramatic worsening of his symptoms during a myelogram examination of the neck. It is suggested that computed tomographic imaging of the neck is the preferred investigative procedure if OPLL is suspected as a cause of cervical myelopathy.

Cervical Vertebrae↗
PubMed1983

Comparative study of the sodium salts of iodamide and iothalamate in clinical urography.

In a comparative urographic study of the sodium salts of iodamide (Uromiro 300 Sodium) and iothalamate (Conray 420) the following conclusions have been made. (i) In subjects with radiologically normal kidneys and a creatinine clearance greater than 70 ml/min, nephrogram scores were significantly higher with iodamide (P less than 0.02). There were differences between the media in respect of total urogram scores and pyelogram scores but they were not statistically significant. (ii) In patients with radiologically normal kidneys and a spectrum of normal and abnormal renal function, performance scores for iothalamate showed no significant relationship with creatinine clearance. Results for iodamide, however, showed some relationship with creatinine clearance (nephrogram score r = 0.46, pyelogram score r = 0.38, total urogram score r = 0.49). A possible mechanism for this is proposed. (iii) Side-effects encountered in the study were mild and there were no significant differences between the contrast media in either the incidence or severity of the side-effects. (iv) Blood-pressure and pulse-rate profiles following iodamide were not significantly different from those following iothalamate. (v) Cardiac arrhythmias were mild and uncommon.

Adult↗
PubMedDate not supplied

Ventricular septal defect and multiple aneurysms.

A 41-year-old man with a small perimembranous ventricular septal defect (VSD) developed aneurysms and aortic elongation, tortuosity and dissecting aneurysm. The asymptomatic VSD, without pulmonary circulatory disturbance, was considered hemodynamically benign and too small to warrant surgical closure. However, prolonged strenuous sporting activities could have potentiated premature development of aortic sclerosis and the unusual vascular lesions secondary to the VSD, and an injury may have precipitated mural dissection in the vulnerable aortic wall. Clinicopathological analysis of the unusual complications associated with the VSD suggests that closure of the defect at an early age should be considered to possibly obviate premature degenerative, valvular and vascular changes in adulthood and also secondary endocardial infection.

Adult↗