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Biomedical subjects

T P Maznina

Publications and source records attributed to T P Maznina.

4 recordsLinked to original sources
PubMed1978

[Quantitative assessment of antithymocyte antibodies in schizophrenia].

The use of the method of fluorescent antibodies and cytotoxic tests showed that the blood serum of schizophrenic patients and normals possess an antithymocytic activity. However, the level of this activity in patients exceeds the corresponding indices in normals (p less than 0.02). The use of indirect immunofluorescent methods permitted to demonstrate that the antithymic antibody titres in schizophrenic patients is much higher than in normals. The amount of the cytotoxic index is in direct correlation with the level of antithymic antibodies determined by the fluorescent antibody method.

Adult↗
PubMed1977

[Effect of schizophrenic patients' serum on DNA synthesis in cultures of PHA stimulated lymphocytes].

The authors studied the influence of the blood sera of schizophrenic patients on the DNA synthesis in a PHA stimulated lymphocyte culture of normal donors. It was established that in 13 of the 15 studied patients the blood sera contained factors, inhibiting the DNA synthesis in lymphocytes in normals. The reactivity of lymphocytes on the PHA was in an inverse correlation with the figure of the cytotoxic index. The assumption is being made that the inhibiting action of the serum is conditioned by the presence of antibodies to thymocytes and T-lymphocytes.

Cells, Cultured↗
PubMed1976

Studies on human brain-thymus cross-reactive antigens.

Antigens shared by human brain and thymocytes and by human and mouse tissues were studied with rabbit anti-human thymocyte antiserum (RAHT). It was found that cytotoxicity of RAHT serum against mouse thymus cells was not absorbed by mouse liver or bone marrow cells. Human brain and thymus cells completely absorbed the anti-thymocyte activity from this antiserum. It was suggested that human brain had antigenic determinants identical or very similar to those found on human thymocytes. Activity of RAHT antiserum against mouse thymus cells was completely removed by an absorption of mouse brain and thymocytes. These results demonstrated that there were shared antigenic determinants between human and mouse tissues.

Adult↗