Biomedical subjects

T Pérez-Medina

Publications and source records attributed to T Pérez-Medina.

10 recordsLinked to original sources

PubMed2007

The labor induction: integrated clinical and sonographic variables that predict the outcome.

OBJECTIVE: To analyze the clinical and sonographic variables that predicts the success of labor induction. STUDY DESIGN: We studied the Bishop score, cervical length and parity in 196 pregnant women in the prediction of successful vaginal delivery within 24 h of induction. Logistic regression and segmentation analysis were performed. RESULTS: Cervical length (odds ratio (OR) 1.089, P<0.001), Bishop score (OR 0.751, P=0.001) and parity (OR 4.7, P<0.001) predict the success of labor induction. In a global analysis of the variables studied, the best statistic sequence that predicts the labor induction was found when we introduced parity in the first place. The success of labor induction in nulliparous was 50.8 and 83.3% in multiparous women (P=0.0001). CONCLUSIONS: Cervical length, Bishop score and parity, integrated in a flow chart, provide independent prediction of vaginal delivery within 24 h of induction.

Adult↗

PubMed1999

Atypical endometrial hyperplasia treatment with progestogens and gonadotropin-releasing hormone analogues: long-term follow-up.

OBJECTIVE: The aim of this study was to assess the long-term effect of gonadotropin-releasing hormone analogues (GnRH-a) in combination with high-dose progestogens in the treatment of atypical endometrial hyperplasia in selected surgical high-risk patients and in women desiring reproductive potential. We hypothesized that this therapy is effective for most couples. METHODS: In the Department of Gynecology of a university hospital, a conservative treatment was offered to a series of 22 patients with atypical endometrial hyperplasia who had a surgical or anesthetic risk history or wished to preserve their fertility potential. After informed consent, they were treated with 500 mg norethisterone acetate weekly for 3 months and 3.75 mg Triptorelin depot every month for 6 months. Three patients failed to complete the study, so the group finally consisted of 19 subjects. They were prospectively followed for 5 years by hysteroscopy and multiple selected biopsies every 6 months. RESULTS: At a 5-year follow-up, regression was noted in 16 patients (84.2%), persistence in 1 (5.1%), recurrence in 1 (5.1%), and progression in 1 (5.1%). CONCLUSION: Consistent with our hypothesis, combined treatment with progestogens and GnRH-a is an effective alternative in selected patients with atypical endometrial hyperplasia.

Adult↗

PubMed1985

Effect of increased levels of free fatty acids on the size of the ischaemic area.

Mongrel dogs, anaesthetized with sodium pentobarbital were artificially ventilated and prepared in order to produce a 3-min occlusion of the left descending coronary artery. High serum levels of free fatty acids (FFA) were obtained by infusion of Lipofundin (1 and 3 ml/min). A significant increase in the size of the ischemic area was found following a 3 ml/min infusion rate of Lipofundin, and in 2 out of 7 and 1 of 7 dogs ventricular extrasystoles and ventricular fibrillation respectively appeared. It is concluded that high level of FFA early after coronary occlusion can increase the size of the ischaemic area and can secondarily produce ventricular arrhythmias.

Animals↗

PubMed1979

Comparison of the effects of atenolol and propranolol in labile hypertension.

The effects of a single daily dose of 100 mg. of atenolol and an equivalent dose of propranolol were compared during a crossover, 15 day blind trial in a group of young labile hypertensives. Arterial pressure, heart rate, systolic time intervals and the carotid pulse upstroke time, recorded by external non-invasive procedures, were measured before and 4 and 8 hours after the last dose of both drugs. Both beta blocking agents significantly reduced and stabilized the arterial BP and the heart rate to normal values. However, a tendency to return to abnormal values was observed 8 hours after propranolol administration. Both drugs provoked an increase in the pre-ejection period, but with propranolol this increase was related to a larger isovolumetric contraction time, pointing to a negative inotropic action. The carotid pulse upstroke time was increased to normal values with atenolol. Propranolol failed to alter this value. Atenolol in a single oral daily dose is recommended in the treatment of labile hypertension.

Adult↗

PubMed1977

Antiarrhythmic effect of disopyramide injected into the sinus nodal artery.

In a anaesthetized dogs, the antiarrhythmic drug disopyramide was injected directly into the sinus nodal artery in doses that ranged from 10 to 200 microgram/ml. Lower concentrations of the drug induced a non-significant increase in sinus rate of atropinic origin and were incapable of blocking atrial fibrillation induced by 10 microgram/ml of acetylcholine injected into the sinus modal artery. Only concentrations higher than 100 microgram/ml of the drug, which caused bradycardia, proved to be effective in preventing the arrhythmia. It is concluded that the antidyshythmic effect of disopyramide in sinus arrhythmia is a consequence of a direct negative chronotropic effect opposite to its known atropinic effect.

Acetylcholine↗

PubMed1976

Dehydrobenzperidol and disopyramide in A-V conduction.

The effects on A-V conduction of dehydrobenzperidol (Droperidol) 0.35 and 1.0 mg/kg i.v.) and disopyramide (1, 5 and 10 mg/kg i.v.) were tested in anesthetized, open chest and paced dogs. His's bundle electrograms were recorded by means of a catheter electrode or by a sutured electrode-bearing plaque in the A-V nodal region. Droperidol at the lower dose did not modify conduction time, while 1.0 mg/kg (3 times the usual clinical dose), prolonged atrial-His conduction without modifying H-V interval. Disopyramide 1 mg/kg caused a non-significant decrease in atrial-His concuction time, while in doses of 5 and 10 mg/kg it prolonged both conduction times (S-H and H-V), due to a predominant direct depressant effect, which is opposite to the atropinic actions of the drug.

Animals↗

PubMed1976

Chronotropic effects of droperidol.

To study the mechanism of action by which droperidol exerts a negative chronotropic effect, 3 series of experiments were performed: a) on isolated right atria of rabbits, b) on the isolated vas deferens of guinea-pigs and c) by injecting the drug directly into the sinus node artery of anesthetized dogs. Isolated tissue results include: lack of cholinergic action or beta-adrenergic antagonism: a calcium ion flux interference could not be demonstrated. Alpha adrenergic antagonism of the drug (pA2) was ascertained in the vas deferens. Injections of droperidol in the sinus node artery caused a negative chrontropic effect proportional to the dose and arrest ensued with the largest dose followed by His escape rhythm. Droperidol could not inhibit isoproterenol or dopamine-induced tachycardia and showed similar negative chronotropism in vagotomized and atropinized dogs. Negative chronotropic effects of the drug appear to be caused by an exit blockade of sinus impulses.

Animals↗

PubMed1972

Experimental His bundle escape rhythms.

With the purpose of studying the interactions between sino-atrial (S-A) node and His bundle escape rhythms (HBER), negative chronotropic agents (verapamil, manganese and droperidol) were directly injected in the canine S-A node through its cannulated and autoperfused artery. HBER followed S-A node depression assessed by His bundle electrograms. A well established correlation was found between HBER and S-A node initial rate. His bundle recovery time following an atrial overdrive was 50 times larger than the S-A node recovery time. HBER was found to be more sensitive to sympathetic blockade than to vagal influences. It is concluded that 1) recovery time following overdrive stimulation is a valid index reflecting sinus nodal function; 2) HBER commonly results from selective depression of the S-A node not only depends on rate but also on overdrive suppression; 4) HBER is more sensitive to sympatheticmodulation.

Animals↗

PubMed1972

Effect of atenolol in angina pectoris of effort.

The effect of atenolol, a new cardioselective beta-adrenogenic blocking agent, was studied in 11 patients with angina of effort in a double-bind trial involving monitored exercise tolerance tests. The drug significantly reduced the heart rate, blood pressure and time-tension index. As a result, ST segment depression also diminished after treatment. Although working capacity, compared with controls, increased after atenolol, no difference was observed in this respect between the drug and placebo, suggesting the development of physiological tolerance to exercise. It is concluded that atenolol is useful in the prevention of angina pectoris, particularly in patients in whom there is associated arterial hypertension.

Adult↗

PubMedDate not supplied

[Preventive disopyramide in patients with ventricular arrhythmias detected by exercise].

Twenty patients with coronary heart disease subjected to exercise testing presented ventricular arrhythmias. In a "double blind" design, oral disopyramide was administered during 7 days, after which the test was repeated. In 16 patients disopyramide prevented the appearance of arrhythmia or decreased their severity. Basal heart rate increased. Significant toxic or colateral effects were not observed. In 6 cases, placebo also hindered exercise arrhythmias. It is suggested that disopyramide may be useful in the prevention of sudden death from ventricular arrhythmias.

Adult↗