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Biomedical subjects

T Pasini

Publications and source records attributed to T Pasini.

6 recordsLinked to original sources
PubMed1992

[Effects of propofol and isoflurane on the neuromuscular block induced by atracurium].

Speed of onset, duration of action and recovery time for a bolus injection of atracurium were measured in two groups of patients. In group I anaesthesia considered of propofol, fentanyl, nitrous oxide and oxygen mixture. The induction dose of propofol was 2 mg/kg-1 followed by an infusion of 9.0 mg/kg-1/h-1 for first half hour and 4.5 mg/Kg-1/h-1 subsequently. In group II anaesthesia consisted of isoflurane, fentanyl, nitrous oxide and oxygen mixture. Isoflurane was given upon clinical needs. Speed of onset, duration of action, and recovery time for atracurium were measured in the two groups. No statistically significant differences between speed of onset and duration of action between the two groups were found. The recovery period from T1 = 10% to T1 = 70% twitch response was considerably longer with isoflurane (25 min +/- 6) than with propofol (18 min +/- 3) (p less than 0.01). Results obtained suggest that for adequate relaxation during tracheal intubation smaller doses of atracurium are not needed during isoflurane than propofol administration. Because of the longer recovery period of residual neuromuscular blockade during isoflurane anaesthesia decreasing doses of atracurium and careful monitoring of twitch depression tension are also suggested.

Adult↗
PubMed1992

[Cranial trauma and prehospital care. Evaluation of the effectiveness of early treatment].

The role of pre-hospital care is still to be stressed especially in case of head injuries. We compared two groups of head injuries (total 50 patients, 38 politrauma) transported by traditional ambulance (28 patients) or by EMS helicopter (22). The two populations had similar values of the considered indices (TS, ISS, GCS, TRISS). They significantly were different only for the "free therapy time". Patients transported by ambulance showed an higher incidence (p less than 0.01) of acute complications (like hemorrhage and hypovolemic shock) despite the same gravity score indices. The index applied for the follow-up valuation, does not show any difference in the two groups. This may be due to the unreliability of the used scores if they are applied without any correlation with the quality of care during the transport.

Brain Injuries↗
PubMed1991

[Method for the analysis of changes in mixed venous oxygen saturation in vascular surgery].

Continues monitoring of SvO2 was carried aut using an Oxi metrix pulmonary arthery catheter in 12 patients undergoing aortic surgery. Hemodynamic measurements were made before skin incision (baseline values), before aortic cross clamping, after aortic declamping and postoperatively during shivering. Hemodynamic measurements were also taken whenever SvO2 changed more than 10% from baseline value. Results showed that in clinical setting, if SvO2 do not change more than 10% from baseline values, an equilibrium exists between oxygen delivery (DO2) and oxygen consumption (VO2). As DO2 and VO2 were correlate after measuring cardiac output from the same technique, a mathematical correction of a common error for linear calculations was applied. It was also concluded that changes of SvO2 greater than 10% of baseline values should prompt the assessment of hemoglobin, cardiac output, SaO2 and oxygen demand, but changes of SvO2 less than 10% of baseline value should not prompt measurements.

Aged↗