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T Passeron

Publications and source records attributed to T Passeron.

At least 19 recordsLinked to original sources
PubMed2006

Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years.

BACKGROUND: Appropriate use of prebiotics and optimal combinations of probiotics and prebiotics (synbiotics) could allow significantly better results to be obtained in the treatment of atopic dermatitis (AD). OBJECTIVE: To evaluate the efficiency of synbiotics when compared with prebiotics alone (control group) in the treatment of moderate and severe AD in children aged 2 years and over. METHODS: Double-blind prospective randomized study performed on children aged at least 2 years presenting AD with a minimum SCORing Atopic Dermatitis (SCORAD) score of 15. A dose of 1.2 x 10(9) colony-forming units Lactobacillus rhamnosus Lcr35 plus prebiotic preparation or an identically appearing prebiotic preparation alone was given three times a day for 3 months. Patients' diet and usual treatment for AD remained unchanged during the study period. Efficiency was evaluated using the SCORAD score. Use of topical drugs was noted. RESULTS: A total of 48 patients were originally enrolled; nine did not complete the study. In synbiotic group, the mean values of the total SCORAD score was 39.1 before treatment vs 20.7 after 3 months of treatment (P < 0.0001). In the prebiotic group, the mean of the total SCORAD score was 39.3 before the treatment vs 24.0 after 3 months (P < 0.0001). After 3 months of treatment, no statistical differences between the two treatment groups with regard to the total SCORAD score were noted (P = 0.535). Neither were there any statistical differences in the total use of ointment between patients receiving prebiotics or synbiotics (P = 0.966) over the study period. Tolerance was excellent in both groups. CONCLUSIONS: Both synbiotics and prebiotics used alone seem able to significantly improve the manifestations of AD in children aged 2 years and over.

Child↗
PubMed2004

Treatment of vitiligo by 308-nm excimer laser: an evaluation of variables affecting treatment response.

BACKGROUND AND OBJECTIVES: To determine the true efficacy of the 308-nm excimer laser for the treatment of vitiligo, while taking into account confounding factors such as anatomic site of treatment, age, sex, skin type, MED, and duration of evolution of the vitiligo. STUDY DESIGN/MATERIALS AND METHODS: Thirty-five patients with vitiligo were included. Each lesion was treated twice a week by the 308-nm excimer laser for a maximum of 24 sessions. Efficacy was blindly evaluated by two independent physicians. RESULTS: Repigmentation was noted in 46 plaques/52 (88.5%). Repigmentation rate (75%) was obtained in 14 (26.9%). In "UV sensitive" areas (face, neck, trunk), 8/14 lesions (57.1%) had a repigmentation rate, 75% versus 6/38 (15.8%) in "UV resistant" areas (bony prominences and extremities) (P = 0.031). No relationship could be established between response to the treatment and the following variables: age, sex, skin type, MED, and duration of evolution of the vitiligo (respectively, P = 1, 0.666, 0.566, 0.628, 0.521). CONCLUSIONS: An aesthetically reasonable result is achieved essentially in "UV sensitive" areas, thus appearing to be the appropriate places of choice for this treatment.

Adolescent↗
PubMed2003

[Concurrent mycetoma and chromomycosis: case report from Senegal].

A 68-year-old cattle farmer from northern Senegal sought medical attention for tumefaction that had been progressing on the right foot and leg for 20 years. Physical examination of the right extremity revealed very firm tumefaction involving the foot and whole leg associated with numerous nodules. Bone radiographs and CT-scan of the foot and leg disclosed extensive osteolytic involvement. A specimen of squamous tissue from the top of nodules showed the presence of fumagoid cells characteristic of chromomycosis. Histologic examination after skin biopsy demonstrated fungal myocetoma. Due to the extent of involvement surgical and antifungal treatment was proposed but the patient refused to undergo surgery. Only one previous case of concurrent chromomycosis and mycetoma has been described. However the previous case involved actinomycetoma. The rarity of this combination of diseases despite their common contamination mode is due to different geographical distribution with mycetoma being found in the Sahelian region and chromomycosis in the humid equatorial region.

Aged↗
PubMed2002

[Salmonella enteritidis splenic abscess complicating a Plasmodium falciparum malaria attack].

INTRODUCTION: Salmonella splenic abscesses are rare and usually occur on pre-existing lesions. OBSERVATION: A Moorish 16 year-old woman from Senegal presented with a S. enteritidis abscess without any factor other than an attack of P. falciparum malaria. Treatment associated quinine salts, antibiotherapy and splenectomy. COMMENTS: P. falciparum malaria attacks not only induce humoral and then cellular immunodepression but are also at the origin of infarction or splenic hematoma that may enhance bacterial infection and the development of abscesses. Splenectomy or percutaneous drainage associated with antibiotherapy is the usual treatment for splenic abscesses. Prognosis remains severe (13 to 16% mortality).

Abscess↗
PubMed2002

Treatment of vitiligo by topical calcipotriol.

OBJECTIVE: Evaluation of the efficiency of topical calcipotriol monotherapy in vitiligo. MATERIALS AND METHODS: This was a prospective, right/left comparative, open study at the Dermatology Department at the University Hospital in Nice, France. Twenty-four patients with localized or generalized vitiligo with symmetrical lesions were included. The main outcome measure was the evaluation of the percentage of repigmentation in treated target lesions and untreated control lesions for each patient. RESULTS AND CONCLUSIONS: Topical calcipotriol in monotherapy is not an effective treatment of vitiligo.

Administration, Topical↗
PubMed2001

[First case of cutaneous plasmocytoma in Africa].

Cutaneous plasmacytoma are dermo-hypodermic plasmacytic infiltrations. Occurrence is quite rare. Primary plasmacytoma and metastatic plasmacytoma in myeloma are distinguished. Firm, asymptomatic unique or multiple nodules are the common clinical form. We report the first african case of cutaneous plasmacytoma occurring in an IgG myeloma. It was a 73 year-old man with history of IgG myeloma, stade III of Durie and Salmon classification. At his third chemotherapy, he presented a pre-stemal nodule growing since 15 days. Histologic examination confirmed the diagnosis of cutaneous plasmacytoma. One months later news nodules and cranial lacunas were observed. It is important for the clinician to well known this complication of myeloma because of its bad prognosis. Moreover it should make modify the therapeutic protocol, if it's possible.

Aged↗
PubMed1999

[Psoriasis. Clinical cutaneous aspects].

PREDOMINANT FEATURES: Psoriasis is a frequent inflammatory dermatosis. All age groups are involved. The typical lesion is a well-limited erythemato-squamaous non-pruriginous lesion. All skin areas may be involved but each individual has preferential zones. CLINICAL COURSE: This chronic condition progresses by acute flare-ups which occur at variable frequency and with variable intensity. SEVERITY: Although psoriasis is a benign dermatosis, the psychosocial impact must not be overlooked. Life-threatening forms do occur (generalized or erythrodermic pustulous psoriasis). SPECIAL FORMS: HIV serology would be advisable if sudden aggravation occurs in a patient with no known triggering factor. Late onset psoriasis in a patient with no familial history or particular risk factors may also suggest possible HIV infection.

AIDS-Related Opportunistic Infections↗