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Biomedical subjects

T Perković

Publications and source records attributed to T Perković.

8 recordsLinked to original sources
PubMed1998

Skeletal muscle immune deposits in systemic lupus erythematosus. Correlation with histologic changes, autoantibodies, and clinical involvement.

Skeletal muscle biopsy and autopsy samples of 132 SLE patients were studied by immunofluorescence and light microscopic techniques. Immune deposits were compared to histologic abnormalities and clinical and serologic findings. Immune deposits with a mainly granular pattern were observed at different locations in 49 patients (37%). They correlated significantly (p<0.001) with inflammatory myopathy, demonstrated in 33(25%), with noninflammatory myopathy which occurred in 38 (29%) vasculitis, observed in 13(10%), and with noninflammatory vasculopathy which was noted in 10 patients (8%). The correlation of muscle immune deposits with anti-DNA antibodies was significant at p= 0.016. Anti-Sm and anti-U1 RNP antibodies were associated significantly with the intensity of immune deposits. Furthermore, a correlation of immune deposits with increased creatine phosphokinase and myopathic electromyogram, but not with evidence of clinical involvement, was shown. A key pathogenetic role of immune deposits in the development of skeletal muscle histologic abnormalities in SLE was demonstrated.

Adolescent↗
PubMed1997

Langerhans and other immunocompetent cells in vocal cord epithelial hyperplastic lesions of patients with chronic laryngitis.

The aim of the study was to evaluate the intraepithelial and stromal density of Langerhans cells and lymphoid infiltrate in different stages of carcinogenesis in vocal cord biopsies of 24 randomly selected patients with chronic laryngitis. The Langerhans and lymphoid cells were counted using immunolabelling with antibodies against CD1a, S100, CD3, CD20, and CD68 on paraffin-embedded sections of 24 archival laryngeal vocal cord mucosa biopsy specimens, 6 classified as simple, 7 as abnormal, and 11 as atypical epithelial hyperplasia. Results were statistically evaluated using the Kruskal-Wallis and Wilcoxon sign rank tests. The mean number of Langerhans cells and T lymphocytes per mm2 of cross-sectioned epithelium was found to increase from simple to atypical hyperplasia. There were statistically significant differences in Langerhans cell density between atypical hyperplasia and each of the other 2 grades, simple and abnormal hyperplasia, with p < 0.05. Our study suggests the involvement of immune mechanisms, particularly cell mediated, during laryngeal carcinogenesis and the possibility that the assessment of Langerhans cell density might be of prognostic significance.

Adult↗
PubMed1989

[Utilization of findings from computerized tomography of the brain in psychiatric diagnosis].

The application and critical evaluation of brain-computed tomography (CT) to psychiatry are presented primarily in relation to the cerebral atrophies and organic brain syndromes. It can be observed, that clinical diagnosis of brain atrophy is frequently made only upon findings of diffuse cortical atrophy. The attention is directed to the non-consistent CT scan measures and diagnostic criteria of brain atrophy on CT scan due to non-consistent methodologies of sulcus and ventricular measurements. The linear and planimetric measurements and difficulties in exact analysis of cerebral atrophy on CT scanning are discussed. The nosology, clinical criteria and etiology of chronic organic brain syndromes, the clinical conditions and diseases connected with diffuse cerebral atrophy noticeable on CT scan are reported. The conclusion is, that diffuse cerebral atrophy on CT scan without clinical symptoms and criteria of cerebral atrophy cannot be considered as basis for making psychiatric diagnosis, respectively, that such finding needs other exact clinical, psychiatric and psychological examinations.

Atrophy↗
PubMedDate not supplied

[Psychiatry--where are we and where are we going?].

The article gives a short review of the historical, ideological, theoretical and organizational development of the concept of protection and improvement of mental health (within a psychiatric context) both in Croatia and the rest of the world with special emphasis on the problems and possibilities which arise from the present situation in Croatia. It also explains the necessity to analyze the Law on Health Care and Health Insurance from a psychiatric point of view, the need to link the areas of psychiatry (preventive and clinical work) which deal with primary protection, the need to define the criteria and standards regarding the organization and reorganization of psychiatric clinics and general hospitals, the need to analyze and reorganize the study of psychiatry, the need to establish national and regional coordination boards and hold elections for national and regional coordinators and the need to establish the Centre for the Protected and Improvement of Mental Health.

Croatia↗