Biomedical subjects
Publications and source records attributed to T Petkov.
Two cases are reported of malignant insuloma: in one of the patients the tumor was hormonally active in the other inactive. Treatment was operative. The great difficulties in establishing the diagnosis preoperatively and the complications accompanying this grave disease are pointed out. The clinical and laboratory examinations which may help to reach at the correct diagnosis are discussed.
During the period June 1986-January 1988, 10 patients with advanced bladder tumors were treated by systematic intra-arterial chemotherapy with Cyclophosphamide 800-1,000 mg/m2, Farmorubicine 40-50 mg/m2, Biocisplatin 60-70 mg/m2, combined with bladder instillation of BCG using 6 ampoules of Calgevax vaccine 0.6-1.8 x 10(9) in the form of a long term therapeutic treatment. The patients, who had stage T2, T3 or T4 tumors either had contraindications to surgery or refused surgical treatment. Two patients showed very good results following the treatment. One patient had a relapse after surgical treatment but is currently in complete surgical remission. Four patients, i.e. 40%, had a partial response; 8 months later progression of the disease was noted in one case, while in the 4 others the disease was stable. The mean survival rate from the start of treatment was estimated at 12.4 months, and ranged from 8 to 20 months. There were no cases of activation of the disease following administration of the above treatment. The results obtained should be considered as preliminary in view of the small number of patients and the short period of follow up. Nevertheless, these preliminary satisfactory results are a starting point for the performance of larger and more involved studies related to research into the new possibilities of chemotherapy associated with immunotherapy in the treatment of bladder tumors.
The birth of hypotrophic piglets with 2-3 times lower live weight than the normally born ones, which die till the 40th hour, because of the abruptly decreased vitality is described. Their percent is 7 for the reproductive bases and 10 for a commodity swine breeding complex. Studies were carried out on 402 pregnant pigs, treated with protein hydrolysate and glucose (injected) together with vitamin-mineral additions to the forage. For a control were used 395 pregnant pigs under the same conditions, but not treated with the above mentioned medicines. A two fold decrease of the birth of hypotrophic piglets was achieved. The rest of the pigs are with a higher live weight and vitality which is the reason of their suffering from coli bacteriosis and other diseases of the conditions at a considerably lower extent. It is supposed that the irreplaceable (limited) amino acids are at the base of that biological phenomena for the prophylaxis of the hypotrophy in the pathology of the hybrid industrial swine breeding. That model scheme as a method can be realized in reproductive and nuclear bases for hybrid swine breeding because of its undeniably great and economic effect.
Explore the source record for details and available documents.
Explore the source record for details and available documents.