Biomedical subjects

T Petkovits

Publications and source records attributed to T Petkovits.

5 recordsLinked to original sources

PubMed1991

Diethylene glycol (DEG)-associated myocardial changes: a pilot investigation of chronic intoxication in guinea-pigs.

The myocardium of guinea pigs fed on sublethal doses of diethylene glycol (DEG) over a period of 2-11 days was examined for microscopical and ultrastructural changes. Coagulative myocytolysis and loss of myofibrils, not observed in the controls, was patchily distributed throughout the myocardium. The accompanying ultrastructural features included swelling, pleomorphism and hyperplasia of mitochondria with an associated distension of the interfibrillary spaces and a displacement, distortion and rupture of adjacent myofibrils.

Administration, Oral↗

PubMed1990

[Ultrastructural pathology of mechanical skeletal muscle damage].

In continuation of previous light microscope investigations the question has been raised whether the criteria determined for vital muscle damage using light microscopy, could be verified and perhaps extended for the ultrastructural region. In addition to existing human pathological material taken early post mortem, muscle tissue obtained from animal experiments was also examined. The evaluation concentrated on the muscle cells, the cell organelles and the contractile apparatus. An evaluation of semi-thin-sections was carried out in parallel. The following reaction patterns could be defined as vital reactions: hypercontraction bands, zones of rupture in narrow topological relationship to organelle changes, microstructure changes with disintegration of the fibre structure, subsarcolemmic and interfibrillary oedema, decomposition of the sarcolemma. The earliest vital reactions were detectable after only a few minutes survival time. The comparison between the results of animal experiments and human pathology and the application of the results to forensic pathology will be discussed.

Animals↗

PubMed1989

[Forensic medicine and toxicologic aspects of 2-propanol poisoning].

Two cases of poisoning with 2-propanol (isopropylalcohol) are reported. In one case, nail polish remover was drunk by a 2-year-old child. The concentration of 2-propanol and its metabolite acetone in the blood could be observed over a period of approximately 50 h. The highest concentration of 2-propanol determined was 4.22 g/l. Acetone reached a maximum value of 2.27 g/l 12 h after ingestion. The child survived without any observable after-effects. In the second case, a 35-year-old man drank ethanol in addition to 2-propanol. The poisoning was lethal. The possible time of intake before death is discussed in relation to the estimated levels of ethanol, 2-propanol and acetone found in the blood and urine. The histomorphological findings are often important as well with regard to time of intake.

1-Propanol↗

PubMedDate not supplied

[Unusual suicides with chain saws].

Two cases of suicide with bandsaws, undertaken by workers in carpenters' workshops are reported and discussed. Their choice of this method was based on the fact that they knew how dangerous such machines were. Both cases were watched by witnesses, who could not intervene due to the speed of the events. It was possible to exclude accident or homicide.

Adult↗

PubMedDate not supplied

[Morphologic identification of mummified tissue traces].

Post mortem tissue samples from various human organs (skin, muscle, liver, kidney, brain) were stored at room temperature for a period of one year. During this time the samples were regularly histologically tested. Without any pretreatment of the samples a histological preparation and identification was no longer possible after only a few hours. By the use of a rehydration solution consisting of absolute ethanol (30 ml), aqua dest. (50 ml) and 0.2 M phosphate buffer pH 7.0 (20 ml) a reconstitution and identification was again possible. Further immunhistochemical examinations were also unaffected by the solution. The use of microwave stimulation allowed a reduction of the rehydration process from 24 hours to only 4 hours.

Brain↗