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T Plappert

Publications and source records attributed to T Plappert.

39 records · Page 3Linked to original sources

Two dimensional echographic imaging of the left ventricle: comparison of mechanical and phased array systems in vitro.

To determine the reliability of two dimensional echographic images of the left ventricle with different two dimensional echographic instruments, two dimensional echographic images of the left ventricle were compared in vitro using two phased array and two mechanical systems to image 22 short axis slices of the three postmortem human hearts (one with infarction, one with left ventricular aneurysm, one with mitral regurgitation). Total left ventricular area and left ventricular cavity area were determined with planimetry and myocardial area was derived by subtraction. Comparison of total, myocardial and cavity areas with calibrated photographs of each slice showed excellent correlations for each echographic system (r = 0.93 to 0.97 for total area; 0.90 to 0.94 for cavity area; 0.89 to 0.95 for myocardial area). For total left ventricular area, the ratio of echographic to photographic image size was close to unity (0.95 to 1.08) for one mechanical and two phased array systems, but significantly lower for mechanical system 2 (0.71, p less than 0.001). For myocardial area the echographic/photographic ratio was also close to unity (0.96 to 1.15) for two phase array systems and mechanical system 1 but significantly lower for mechanical system 2 (0.77, p less than 0.005). In contrast, all systems underestimated left ventricular cavity area with lower, more variable echographic/photographic ratios (0.48 to 0.78), with mechanical system 2 again giving significantly lower values (p less than 0.02) than the other systems. Underestimation of left ventricular cavity area appears to result from inaccurate endocardial display. We conclude that accurate left ventricular image quantitation is possible with either phased array or mechanical systems if each variable studied is calibrated against an independent reference standard and echographic results are corrected by the resultant regression equation.

Echocardiography↗

Acute systolic and diastolic indices of left ventricular function after cardiomyoplasty in a chronic model of heart failure.

Recent experimental studies have suggested that the initial nonstimulated stage of dynamic cardiomyoplasty acutely impairs ventricular function. Those investigations were performed on normal hearts and primarily examined diastolic alterations as a result of the passive muscle wrap. The purpose of this study was to assess the acute systolic and diastolic effects of a nonstimulated muscle wrap in chronic heart failure induced by rapid ventricular pacing in canines. Pressure-volume analysis of ventricular function based on conductance catheter volume and micromanometer pressure data was used. Each animal was studied before rapid pacing, before cardiomyoplasty, and immediately after wrap. By the end of the pacing period and before wrap, left ventricular dysfunction developed in all dogs, manifested by significant deterioration of both systolic and diastolic indices of ventricular function, as well as progressive increases in left ventricular volumes. However, no further deterioration with load insensitive indices of systolic or diastolic indicators of ventricular function was found as a result of the passive muscle wrap. These results suggest that the cardiomyoplasty procedure can be safely performed on failing hearts without prohibitive acute impairment of ventricular function.

Animals↗

Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction.

BACKGROUND: Expansion of an acute myocardial infarction predicts progressive left ventricular (LV) dilatation, functional deterioration, and early death. This study tests the hypothesis that restraining expansion of an acute infarction preserves LV geometry and resting function. METHODS AND RESULTS: In 23 sheep, snares were placed around the distal left anterior descending and second diagonal coronary arteries. In 12 sheep, infarct deformation was prevented by Marlex mesh placed over the anticipated myocardial infarct. Snared arteries were occluded 10 to 14 days later. Serial hemodynamic measurements and transdiaphragmatic quantitative echocardiograms were obtained up to 8 weeks after anteroapical infarction of 0.23 of LV mass. In sheep with mesh, circulatory hemodynamics, stroke work, and end-systolic elastance return to preinfarction values 1 week after infarction and do not change subsequently. Ventricular volumes and ejection fraction do not change after the first week postinfarction. Control animals develop large anteroapical ventricular aneurysms, increasing LV dilatation, and progressive deterioration in circulatory hemodynamics and ventricular function. At week 8, differences in LV end-diastolic pressure, cardiac output, end-diastolic and end-systolic volumes, ejection fraction, stroke work, and end-systolic elastance are significant (P<0.01) between groups. CONCLUSIONS: Preventing expansion of acute myocardial infarctions preserves LV geometry and function.

Analysis of Variance↗