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Biomedical subjects

T Pope

Publications and source records attributed to T Pope.

At least 19 recordsLinked to original sources
PubMed2004

Growth performance and nitrogen excretion of broilers using a phase-feeding approach from twenty-one to sixty-three days of age.

Two experiments were conducted to assess effects of phase-feeding (PF) on broilers from 21 to 63 d. Experiment 1 evaluated the impact of PF on growth performance, whereas experiment 2 assessed the effects of PF on CP intake and nitrogen excretion. Diets were formulated using recommendations from NRC or linear regression equations. Two PF treatments were prepared: standard (PF) and low (PF10), in which predicted Lys, sulfur amino acid, and Thr recommendations were reduced by 10%. For PF and PF10, 2 diets (high-nutrient and low-nutrient density) were blended in variable quantities to produce rations matching predicted requirements. An NRC grower and finisher diet or a series of PF and PF10 diets that were switched every other day were fed. In experiment 1, weight gain and feed efficiency were improved (P < 0.05) by PF10 relative to broilers fed the NRC-based diet. Crude protein intake was reduced (P < 0.05) by PF10 relative to broilers fed NRC and PF diets. No differences (P > 0.05) in percentage carcass composition were observed when broilers were fed PF or PF10 diets. Significant reductions (P < 0.05) in dollars per kilogram of weight gain were noted with PF regimens. In experiment 2, PF and PF10 diets reduced (P < 0.05) CP intake and nitrogen excretion from 43 to 63 d. Results indicate that PF regimens may substantially reduce dietary costs and may have environmental benefits.

Aging↗
PubMed2002

Growth performance of broilers using a phase-feeding approach with diets switched every other day from forty-two to sixty-three days of age.

Phase-feeding (PF; Treatment 2) was tested relative to an NRC regimen (Treatment 1) to evaluate the impact of PF on broilers during the finisher period (42 to 63 d). Two modified PF treatments were also tested during this experiment: Treatment 3 involved lowering the amino acid requirements predicted with PF linear regression equations by 10% (PF10), Treatment 4 involved increasing the slope of the linear regression equations by 15% (PF15). Broilers fed Treatment 1 consumed a single diet throughout the experiment, whereas PF treatments were fed in a series of 11 diets in which feed was switched every other day, resulting in steadily decreasing lysine, SAA, and threonine levels. On Day 63, weight gain, feed intake, feed efficiency, and crude protein intake did not differ (P > 0.05) among birds fed PF treatments and Treatment 1. Digestible lysine and threonine intakes were increased (P < 0.05) for Treatment 1 relative to the PF treatments, and digestible SAA intake for the NRC treatment was increased (P < 0.05) relative to the PF10 and PF15 treatments. Compared to Treatment 1, no differences (P > 0.05) in percentage breast, wing, leg, or abdominal fat were observed when birds were fed PF, PF10, or PF15 diets. These results indicate that PF supports maximum growth performance during an extended finisher period, even when lysine, SAA, and threonine levels are reduced every other day. Economic analysis indicated that PF regimens may lead to savings ($ per kg weight gain or breast meat).

Amino Acids↗
PubMed2002

Impact of phase-feeding on the growth performance of broilers subjected to high environmental temperatures.

Experiments were conducted to evaluate the effects of phase feeding (PF) on broilers subjected to heat stress during the grower and finisher periods. Birds were fed diets containing lysine, sulfur amino acid (SAA), or threonine levels based on NRC (1994) recommendations or predictions from linear regression equations (PF). With PF, diets were switched every other day, resulting in steadily decreasing lysine, SAA, and threonine levels. In Experiment 1 (42 to 56 d), growth performance was unaffected (P > 0.05) by diet, and cost per kilogram of weight gain did not differ (P > 0.05) between treatments. In Experiments 2 (23 to 42 d) and 3 (42 to 63 d) birds were housed in environmental chambers and subjected to high (15 h at 35 C, 9 h at 23.9 C) or normal (23.9 C) temperatures. In both experiments, heat stress reduced (P < 0.05) growth performance and increased (P < 0.05) percentage leg yield. Moreover, heat stress decreased percentage breast yield (P < 0.05) in Experiment 2. Growth performance and carcass yield were unaffected (P > 0.05) by PF relative to birds fed NRC-based diets, with the exception of feed efficiency, which was reduced (P < 0.05) by PF under normal temperatures in Experiment 2. Data indicated that dietary lysine, SAA, and threonine levels may be reduced every other day under a PF program without adversely affecting growth performance or carcass yield of birds exposed to high environmental temperatures. Cost analysis indicated that savings might be available with PF under high temperature conditions.

Amino Acids, Sulfur↗
PubMed2001

Phase-feeding supports maximum growth performance of broiler chicks from forty-three to seventy-one days of age.

Phase-feeding (PF) was tested to evaluate its efficacy compared with NRC recommendations for broilers. Two modified PF regimens were also tested that involved lowering amino acid requirements predicted by PF linear regression equations by 10% (PF10) and increasing the slope of the linear regression equations by 15% (PF15). Experimental diets were fed from 43 to 71 d. Broilers fed the NRC regimen were given a single diet throughout the experiment, whereas PF, PF10, and PF15 were tested with a series of four diets (43 to 50 d, 50 to 57 d, 57 to 64 d, and 64 to 71 d). At 71 d, no differences (P < 0.05) in weight gain, feed intake, or feed efficiency were observed among treatments. Intake of crude protein, digestible lysine, sulfur amino acids (SAA), and threonine were decreased (P < 0.05) by PF, PF10, and PF15 relative to that of broilers fed the NRC diet. Gain per unit digestible lysine and threonine intake were increased (P < 0.05) by PF, PF10, and PF15, and gain per unit digestible SAA intake was increased (P < 0.05) by PF10 and PF15 relative to broilers fed the NRC diet. No differences (P > 0.05) were observed in carcass, breast, wing, or leg yield, but abdominal fat was increased (P < 0.05) by the PF10 regimen relative to that of broilers fed the NRC diet. Economic analysis indicated that PF and PF10 may lower the cost of feed consumed and the cost per unit weight gain or breast yield relative to broilers fed the NRC diet.

Amino Acids, Sulfur↗
PubMed1999

Kaiser's turnaround: hope for other nonprofits?

After the heady mid-1990's rush of lower premiums, most managed care systems tumbled into a well of red ink. Those hit especially hard were nonprofit MCOs, which have a limited ability to raise capital compared with their nonprofit competitors. However, Kaiser Permanente has reported its first quarterly surplus since 1997, and this has given hope to other nonprofits that they too will soon return to the black. Is this hope justified? Is Kaiser's medicine the right treatment for other integrated systems?

Cost Control↗
PubMed1998

Will physicians lead in the second generation of Medicare managed care?

The one common principle in both managed care today and in the development of new Medicare strategies is increasing physician power from the standpoints of both clinical decision making and governance. In this article, the author explores a few initiatives that seek to hasten the emergence of this "second generation" of Medicare managed care.

Capitation Fee↗
PubMed1996

Affinity maturation of a high-affinity human monoclonal antibody against the third hypervariable loop of human immunodeficiency virus: use of phage display to improve affinity and broaden strain reactivity.

The present study set out to investigate whether phage display could be used to improve the properties of a high-affinity human monoclonal antibody directed against the third hypervariable loop (V3 loop) of human immunodeficiency virus (HIV). The aim was to increase affinity through slowing the dissociation rate (off-rate constant of koff), whilst retaining the ability of this antibody to bind diverse V3 loop sequences. When reformatted as a scFv, the antibody fragment retained the properties of the parental IgG, including the ability to neutralise virus. Heavy and light chains were sequentially replaced with repertoires of variable domains from non-immunised human donors followed by selection on biotinylated synthetic peptide. All selected variants derived from the same germline as the parental antibody. Variants of the light chain provided little if any improvement, whereas two residue changes in VHCDR2 and one in VHFR3 resulted in a reduced koff from gp120 protein of the MN strain (MNgp120) and synthetic V3 loop peptides as measured by surface plasmon resonance using the BIAcore instrument (Pharmacia Biosensor). VHCDR3 was modified using synthetic oligonucleotides and several clones with reduced koff identified, a number of different substitutions occurring at a single residue position. The residues in the heavy chain identified as reducing koff were simultaneously randomised by site-directed mutagenesis, resulting in scFv variants with koff slowed up to sevenfold. Far from compromising recognition of variant loops, binding to these sequences was improved; the koff from synthetic peptides modelled on V3 loop variants being slowed to a degree similar to that observed with MNgp120. All four changes were located towards either extremes of CDRs 2 and 3, suggesting that the mechanism of improvement may be one of alternation of loop conformation. This work illustrates that phage display can be used to tailor the properties of a therapeutic monoclonal antibody in a predefined fashion.

Amino Acid Sequence↗
PubMed1994

Natural disasters: how to resume operations and prioritize your infrastructure.

Earthquakes! Floods! Hurricanes! How is a managed care organization to cope with both delivering health care to its members and maintaining the integrity of its organization? This first article of a two-part series, prompted by the recent spate of natural disasters, discusses how a managed care organization can recompose itself so that it may optimally deliver care to the many people in need after such a catastrophe.

Blue Cross Blue Shield Insurance Plans↗
PubMed1994

Patient care during natural disasters.

Delivering health care requires careful coordination on normal workdays, but during a natural disaster, the organization's planning and management can be sorely tested. The most crucial aspect to consider during a natural disaster is patient care; plans have to prepare for such an event in advance. In this article, the author discusses how some HMOs around the country have coped with providing care for patients during natural disasters and offers some key strategies for successful patient care delivery.

Delivery of Health Care↗
PubMed1991

The role of the chest roentgenogram in febrile neutropenic patients.

In a retrospective review of patients with neutropenia and fever, we sought to determine how often roentgenograms detected pulmonary disease, especially pneumonia, not suggested by signs and symptoms. Further, we sought to determine how often therapy was changed as a result of roentgenographic findings. Overall, 41 (22%) of 187 chest roentgenograms obtained during initial febrile episodes, recurrent fevers, or persistent fevers were abnormal. While most patients had signs and symptoms suggesting the presence of pulmonary disease, 17% had roentgenographic abnormalities detected in the absence of such findings. During initial febrile episodes, therapy was not changed in response to findings on the chest roentgenogram. However, during episodes of persistent or recurrent fever, findings on chest roentgenograms led to changes in therapy in eight (61%) of 13 episodes of which six (40%) resulted in clinical improvement. Chest roentgenograms were therefore found to be an important diagnostic tool in evaluating recurrent or persistent fever in the neutropenic patient but of little use during initial febrile episodes.

Bone Marrow Transplantation↗
PubMed1987

Adolescents' views of intimacy: distinguishing intimate from nonintimate relationships.

Two hundred seventy-seven late adolescents were questioned regarding what they believed differentiated an intimate from a nonintimate relationship. Adolescents' responses supported Erickson's (1963) view of intimacy as being characterized by openness, sharing, and trust, with only minimal differences occurring between the sexes, and relative to current dating/relationship status. Their expressed views varied from Erickson's, however, as they included physical/sexual interaction as a critical component. An additional difference was the relatively few students who included self-abandonment and commitment as necessary elements of an intimate relationship. Explanations for these differences are presented.

Adolescent↗