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Biomedical subjects

T Price

Publications and source records attributed to T Price.

At least 73 records · Page 4Linked to original sources
PubMed1988

PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression.

Patients with right-hemisphere strokes (N = 9) more than 1 year after injury had greater cortical binding of (3-N-[11C]methyl)spiperone than a similar group of patients with left-hemisphere strokes (N = 8) or normal control subjects (N = 17). The higher S2 serotonin receptor binding occurred in uninjured regions of the right parietal and temporal cortex. The ratio of binding in the ipsilateral to contralateral cortex showed a significant negative correlation with severity of depression scores in the left temporal cortex. These findings suggest that the biochemical response of the brain may be different depending on which hemisphere is injured and that some depressions may be a consequence of the failure to upregulate serotonin receptors after stroke.

Adult↗
PubMed1987

Bone density in generalized osteoarthritis.

The densities of trabecular and cortical bone in the radius were measured by computed tomography in 40 women with generalized osteoarthrosis (osteoarthritis, GOA), and the results were compared to normal values obtained from prediction equations. When age, weight and height were considered, no significant differences were observed between patients with GOA and normal controls. But when age only was considered, trabecular bone density in the distal radius was found to be 7% higher than predicted (p less than 0.05). Increased trabecular bone density is unlikely to be an etiopathogenetic factor in GOA although this cannot be completely excluded from our study.

Absorptiometry, Photon↗
PubMed1986

Non-human primate (baboon) anti-carcinoembryonic antigen antibody infusion in patients with metastatic adenocarcinoma. A phase I study.

A total of 14 patients with advanced visceral carcinoma which produced carcinoembryonic antigen (CEA) were treated in a Phase I study with IV infusion of affinity purified baboon anti-CEA antibody (dosage range from 0.1 to 2 mg/kg body weight). In all 14 patients, the antibody infusion caused a decrease (26% to 97%) in the plasma level of CEA. The degree of decrease depended upon the patients initial CEA level and the amount of antibody given. In 12 of the 14 patients "free" circulating antibody was observed. The plasma half-life of the antibody ranged from 0.7 to 21 h and the duration of detectable free antibody ranged from 3 to 216 h postinfusion. No toxicity was observed for the dosage range of antibody tested. In 9 of the 14 patients a low titer anti-baboon antibody response occurred between 14 and 28 days postinfusion. No clinical regression of carcinoma was documented. In 7 of the 14 patients disease remained stable during the 28-day study period. By the end of the 28-day study period plasma CEA levels had returned to at least the preinfusion level in 11 of the 14 patients.

Adenocarcinoma↗
PubMed1986

Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation.

Methapyrilene, four structurally related antihistamines, three metabolites of methapyrilene and two products of the reaction of methapyrilene with nitrite were all tested for mutagenicity to Salmonella typhimurium. The two products of the methapyrilene-nitrite reaction have also been identified as metabolites of methapyrilene. None was mutagenic alone, either with or without rat liver S-9 activation. After reaction with sodium nitrite in acetic acid solution (nitrosation), the products of five of the ten compounds were mutagenic. These compounds were methaphenilene, 2-thiophenemethanol, 2-thiophenecarboxylic acid, N-(2-pyridyl)-N'N'-dimethylethylenediamine and N-(2-thenylmethyl)-2-aminopyridine.

Aminopyridines↗
PubMed1986

Differentiation of Streptococcus sanguis and S. mitior by whole-cell rhamnose content and possession of arginine dihydrolase.

Whole-cell rhamnose concentrations were measured in 48 strains of streptococci resembling Streptococcus sanguis and S. mitior. Physiological characteristics were tested by the API-20/Strep system, and it was found that "typical" S. sanguis (arginine positive, aesculin positive) contained significant amounts of rhamnose, while "typical" S. mitior (arginine negative, aesculin negative) contained very low or undetectable amounts of rhamnose. Both groups contained dextran-positive and dextran-negative strains. Organisms that were more difficult to speciate (those giving positive results in the arginine or the aesculin test, but not in both) could also be divided into a rhamnose-positive and a rhamnose-negative group; with one exception, all of the rhamnose-positive strains gave a positive result with arginine in the API-20/Strep test. There were several discrepancies between the results of conventional tests for arginine and aesculin hydrolysis and those of the corresponding API test. The results of conventional tests for arginine hydrolysis did not correlate closely with rhamnose content, and conventional tests for aesculin hydrolysis were less sensitive than API tests. With the API-20/Strep system, S. sanguis can almost always be distinguished from S. mitior by its ability to hydrolyse arginine.

Arginine↗
PubMed1986

Infarcts of the inferior division of the right middle cerebral artery: mirror image of Wernicke's aphasia.

We searched the Stroke Data Bank and personal files to find patients with CT-documented infarcts in the territory of the inferior division of the right middle cerebral artery. The most common findings among the 10 patients were left hemianopia, left visual neglect, and constructional apraxia (4 of 5 tested). Five patients had an agitated confusional state that was characterized by hyperactivity, restlessness, and easy distractibility. Motor and sensory abnormalities were not severe or persistent. The most common cause was cardiogenic embolism.

Aged↗
PubMed1979

Organic personality disturbance: a case of apparent atypical cyclic affective disorder.

The authors present the case report of a 19-year-old woman that contains several important points in the diagnosis and management of organic personality disturbance associated with temporal lobe epilepsy. The behavioral changes may antedate the onset of the clinical seizure. The diagnosis of complex partial seizures is a clinical diagnosis in which surface EEGs may repeatedly not demonstrate focal activity. Carbamazepine can have important psychotropic effects, in addition to its well-established anticonvulsant effects, and it may be particularly indicated if a lithium-resistant bipolar affective disorder is a differential diagnostic possibility.

Adult↗
PubMed1969

Sodium plus potassium-activated, ouabain-inhibited adenosine triphosphatase from a fraction of rat skeletal muscle, and lack of insulin effect on it.

An ATPase, activated by Na(+) plus K(+) in the presence of Mg(++) and inhibited by ouabain, has been obtained from rat skeletal muscle. Unlike ATPase's with similar properties obtained from other preparations, this ATPase was found only in the fraction containing fragmented sarcoplasmic reticulum. It is suggested that in rat skeletal muscle this ATPase may reside in sarcoplasmic reticulum and not in sarcolemma. This ATPase differed in its pH optimum and in its cation sensitivity from that of rat brain and from that of human muscle reported by Samaha and Gergely (1965, 1966). Because insulin accelerates Na(+) efflux from muscle, efforts were made to determine whether or not this effect of insulin could be attributed to increased Na(+) + K(+)-activated ATPase activity. Insulin, administered either in vivo or in vitro, had no demonstrable effect on the enzyme system, nor did it protect against inhibition by ouabain.

Adenosine Triphosphatases↗
PubMedDate not supplied

The Glasgow Coma Scale in intensive care: a study.

This study reviewed neurological assessment and therapeutic intervention records of adult, intubated, sedated and ventilated patients who had sustained a severe cerebral insult. The purpose of the study was to determine whether the Glasgow Coma Scale detected neurological change in the ventilated, sedated patient. In addition the study aimed to establish whether changes to therapeutic intervention took place in response to an alteration in Glasgow Coma Scale parameters. A retrospective analysis of patient observation records was conducted and descriptive statistics presented. The study found that the Glasgow Coma Scale did not predict or correlate with a sustained rise in intracranial perfusion pressure (ICP) in ventilated and sedated patients. Changes in therapeutic intervention appear to be initiated in response to changes in a number of differing parameters. It is suggested that it may not be appropriate to use the Glasgow Coma Scale as a neurological assessment tool in ventilated and sedated patients.

Adolescent↗
PubMedDate not supplied

Low-dose methotrexate in systemic onset juvenile chronic arthritis.

Twelve children with severe systemic juvenile chronic arthritis, all requiring high dose corticosteroids, have been admitted to a pilot study to evaluate the effect of low-dose methotrexate (mean dose: 8.5 mg/M2) on disease activity over a 6 month period. Definite improvement occurred in 4 children, allowing reduction of the steroid dose in 2 cases. Two children showed an acute flare of disease activity during the treatment period and in three, steroids had to be increased. Overall, side effects were rare with a rise in transaminases only occurring once. MTX blood levels taken on 14 occasions in 8 children documented absorption in all cases with a mean level of 3.45 x 10(-7) mol/l on a mean dose of 9 mg/M2. Low-dose MTX appears to be a safe drug in the short term treatment of severe systemic JCA with beneficial effect in about a third of patients. Long-term controlled trials will be needed to evaluate its role in the treatment of systemic disease as well as side effects.

Absorption↗
PubMedDate not supplied

Indoprofen in juvenile chronic arthritis.

Indoprofen at 10-12 mg/kg body weight was compared with aloxiprin at 80 mg/kg body weight in children suffering from juvenile chronic arthritis. Indoprofen was significantly superior to aloxiprin in reducing soft tissue swelling and joint limitation and was effective in relieving pain and morning slowness and improving grip strength. The drug was well tolerated and is a satisfactory agent for the treatment of chronic arthritis in children.

Arthritis, Juvenile↗