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T R Blake

Publications and source records attributed to T R Blake.

6 recordsLinked to original sources
PubMed1989

A theoretical view of interstitial fluid pressure--volume measurements.

A theoretical description of the mechanics of the interstitium is used to derive a relation for interstitial fluid pressure. The nature of this relation is examined and the dependence of fluid pressure on imbibed fluid, free fluid, and osmotic balances is defined. When the theory is applied to an idealized osmometer configuration, the predicted pressure-volume curve is analogous to the experimental observations of A. C. Guyton (1965, Circ. Res., 16, 452-460). Further, it is suggested that the similarity between the present theory and the experimental data of Guyton supports the hypothesis that a negative interstitial pressure and a dearth of free fluid is an expected and perhaps dominant state of normal tissue.

Animals↗
PubMed1983

Analysis of transcapillary exchange and intraluminal transport in the microocclusion of single capillaries.

A theoretical model, appropriate for data interpretation, is presented for the transcapillary fluid exchange and associated intraluminal hydrodynamic and solute transport occurring in the microocclusion of single capillaries. This analysis describes the spatial and temporal behavior of the intraluminal flow. A comparison of the theory with in vivo data suggests good qualitative agreement with that data and, further, the specification of filtration parameters in the model leads to good quantitative agreement regarding the displacement histories of erythrocytes. The model includes both natural and tagged colloidal osmotic influences and can, therefore, be used to represent experiments wherein the concentration of a dyed colloid is measured and related to fluid filtration. The relative merits of measuring colloidal concentration or erythrocyte displacement are discussed within the context of the model.

Animals↗