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Biomedical subjects

T R Moss

Publications and source records attributed to T R Moss.

30 records · Page 2Linked to original sources
PubMed1986

Evidence of infection with Chlamydia trachomatis in patients with pelvic inflammatory disease: value of partner investigation.

A retrospective analysis was made of the records of 71 women with clinically diagnosed PID presenting to the Department of Genito Urinary Medicine in Doncaster. Twenty-nine of the 71 women (40.8%) showed evidence of active chlamydial infection. Six women (8.5%) had infection with N. gonorrhoeae. Of the 45 male partners investigated, 16 (35.6%) had recoverable C. trachomatis in the anterior urethra. Only four (8.9%) had gonorrhea.

Chlamydia Infections↗
PubMed1985

Failure of in vitro fertilization and embryo replacement following infection with Chlamydia trachomatis.

Antibodies to Chlamydia trachomatis were detected in 54 (47.4%) of 114 infertile women attending Bourn Hall Clinic. Antibodies were solely of the IgG class and mainly of a low titer, suggesting past infection. Antibodies were found in significantly more patients with tubal damage (54.4%) than in women whose infertility was due to other causes (16.6%). Seventy-two women completed in vitro fertilization, with 52 having three embryos replaced. We found that this treatment offered the optimum chance of a pregnancy being established, and 20 (38.5%) of these women became pregnant. Antibodies to C. trachomatis were present in only six (30.0%) of the women becoming pregnant, whereas antibodies were found in 21 (65.6%) of those who failed to become pregnant. Thus past infection with C. trachomatis halved the success rate of in vitro fertilization in these patients. The implications of these findings are relevant to all aspects of infertility from prevention to in vitro fertilization treatment.

Adult↗
PubMed1982

Chlamydia trachomatis in general practice: a preliminary report.

A case of Chlamydia trachomatis diagnosed in general practice is described. It is argued that, in the future, the culture methods used in this study, together with the application of at risk criteria, could identify in general practice most patients suffering from chlamydial disease.

Adult↗
PubMed1981

Evaluation of a culture slide in the diagnosis of vaginal candidosis.

The Till-U-Test Candida Dermatophyte (TUT CD) culture slide, produced for the diagnosis of yeast and dermatophyte infections, was compared with microscopy and formal laboratory culture in the diagnosis of vaginal candidosis. Candida albicans grew readily on the medium and reliable results were obtained within a mean of three days' incubation at room temperature. Agreement with laboratory culture was 91 . 4%; 29% of cases would have been missed by microscopy alone. The TUT CD is a useful device, therefore, in the investigation of vaginitis.

Adolescent↗
PubMedDate not supplied

Antibodies to Chlamydia species in patients attending a genitourinary clinic and the impact of antibodies to C. pneumoniae and C. psittaci on the sensitivity and the specificity of C. trachomatis serology tests.

In a retrospective study, the prevalence of antibodies to Chlamydia trachomatis serovars D to K, C. pneumoniae, and C. psittaci in cases attending a genitourinary clinic was examined. Blood samples were collected from 7,002 cases attending the clinic in Doncaster, England between May 1983 and May 1990. Sera from these samples were tested by a modified microimmunofluorescence test using panels of microdots of egg-grown, purified elementary bodies representing a pool of C. trachomatis D to K, a single C. pneumoniae agent, a single C. psittaci agent, and a negative control. Serum specimens were tested for the presence of IgG and IgM at starting dilutions of 1/16 and 1/8, respectively. Chlamydial IgG at a level of 1/16 or higher and IgM at a level of 1/8 or higher was present in 66.6% and 2.6% of samples, respectively. Species-specific or cross-reactive IgG against C. trachomatis D to K, C. pneumoniae, and C. psittaci was present in 32.6%, 25.1%, and 0.1% of the samples, respectively. In 8.7% of samples, the level of IgG was similar against two or all three species (group-specific). IgM against C. trachomatis D to K, C. pneumoniae, or C. psittaci was present in 2.5%, 0.03%, and 0.04% of the samples, respectively. The results of the study show that antibodies to C. pneumoniae and C. psittaci account for up to half of all chlamydia IgG positive cases attending genitourinary clinics.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Screening colposcopy in genitourinary medicine.

A prospective study of new female patients attending the Genitourinary Medicine Department in Doncaster was carried out to look at the value of colposcopic examination at their first attendance. Of the 100 randomized patients studied 41 showed evidence of colposcopically detected cervical abnormality. Twenty-seven patients had colposcopically directed biopsies. These showed evidence of cervical intraepithelial neoplasia (3 cases), flat condyloma (16 cases), exophytic wart (2 cases), chronic inflammation (2 cases) and normal epithelium (4 cases). Colposcopic cervical abnormalities were significantly associated, with a history of anogenital warts, sexual contact with anogenital warts and the presence of anogenital warts at presentation. Despite this, less than half the group showing colposcopic abnormalities had an association with anogenital warts. Demonstration of cervical abnormalities by colposcopy resulted in a greater patient compliance during follow-up. Screening or primary colposcopy may be incorporated into a genitourinary screen at the first visit. The procedure is both acceptable and beneficial to the patient, facilitating the detection of a range of cervical disease and enhancing the doctor-patient relationship.

Adolescent↗