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Biomedical subjects

T R Robinson

Publications and source records attributed to T R Robinson.

11 recordsLinked to original sources
PubMed2000

Indapamide blocks the rapid component of the delayed rectifier current in atrial tumor cells (AT-1 cells).

We studied the effects of a well known blocker (indapamide) of the slow component (I(ks)) of the delayed rectifier (I(k)) on K(+) currents in atrial tumor myocytes derived from transgenic mice (AT-1 cells) using one electrode voltage clamp method. These cells have been shown to express mRNAs encoding cardiac K(+) channels and display a cardiac electrophysiological phenotype. The major K(+) current is the rapid component (I(kr)) of the delayed rectifier current (I(k)). The purpose of this study was to show that a diuretic agent, indapamide, which was shown to be a selective blocker of the slow component (I(ks)) of delayed rectifier, also blocks I(kr) in a dose dependent manner. The steady state current at the end of a 1s pulse (I(1s), step to +40 mV from a holding potential of -40 mV) was 1070.4+/-202.2 pA (n=5) and the tail current (I(tail)) was 416.3+/-112.9 pA. Indapamide (750 microM) reduced I(1s) and I(tail) to 254.5+/-62.3 pA and 42.2+/-37.7 pA respectively. Indapamide induced block was partially reversible for higher concentrations (> or =750 microM).

Action Potentials↗
PubMed1996

Maternal assessment of infant development: associations with alcohol and drug use in pregnancy.

Surveillance by parental concern has been advocated to assess whether formal child developmental testing is needed. To determine whether alcohol intake or illicit drug use in pregnancy is associated with differences in maternal perception of infant development, mothers with acknowledge alcohol and drug habits during pregnancy (N = 120) were interviewed at 11 months' postpartum, within 1 month before infant testing by use of the Bayley Scales of Infant Development. Women with heavy alcohol intake during pregnancy (> 3.5 oz absolute alcohol per week) were 15-fold more likely to overestimate their infant's mental development (P < 0.05), whereas mothers using illicit drugs were 4-fold more likely to overestimate their infant's physical development (P = 0.02). Given the frequent denial of substance abuse, we suggest that health care providers be cautious in accepting a lack of parental concern about a child's development and rely more heavily on formal testing, particularly in high-risk populations.

Adult↗
PubMed1976

The health of long service tetraethyl lead workers.

Detailed comparison of extensive medical information (results of periodic medical examinations, of medical records of absence from work due to non-occupational illness, and of cumulative medical diagnoses) for workers with 20 years or more TEL service to a matched (for age, sex, race and length of service) group of workers with no occupational lead (TEL or other) exposure shows no significant health differences between the two populations. The conclusion is drawn that, under the conditions have existed at this facility, workers having long occupational exposure to levels of lead (chiefly TEL) sharply in excess of that of the general public, but within a range termed "safe" by current industrial medical standards, have not suffered detectable impairment of health.

Absenteeism↗