The aim of this study was to determine the clinical, echocardiographic, and hemodynamic predictors of left atrial spontaneous echo contrast (SEC) and thrombus, respectively, in patients referred for balloon dilation of the mitral valve and to establish the relationship between the two phenomena in this group of patients. One hundred consecutive patients (mean age 57 +/- 14 years) referred for mitral balloon (Inoue) dilation were studied prospectively with transthoracic and transesophageal (83 biplane and 17 single plane) echocardiography (TEE) combined with spectral and color Doppler modalities, immediately before the procedure. TEE was repeated within 24 hours of valvotomy in the first 55 patients. All patients also underwent comprehensive left- and right-sided heart catheterization. TEE was performed successfully in 96 patients. SEC was detected in all 65 patients in atrial fibrillation and in 14 (45%) of 31 patients in sinus rhythm. Patients with SEC were significantly older (61 +/- 13 vs 45 +/- 12 years; p < 0.001) and had larger left atrial volume (98 +/- 48 vs 64 +/- 24 ml; p < 0.001), higher mitral valve echocardiographic scores (7.4 +/- 3.2 vs 5.3 +/- 2.6; p = 0.016), lower cardiac output (3.5 +/- 1.1 versus 4.6 +/- 0.9 L/min; p < 0.001), lower peak systolic pulmonary vein flow velocity (SVm) (24 +/- 12 versus 45 +/- 11 cm/sec; p < 0.001), and correspondingly lower systolic velocity-time integral (4.0 +/- 2.6 vs 7.9 +/- 2.9 cm; p < 0.001) than had patients without SEC. There were no significant associations between SEC and either mitral valve area or anticoagulant therapy. SVm and atrial fibrillation were found to be independent predictors of SEC. In patients in sinus rhythm, SVm was the only independent predictor of SEC. After mitral balloon dilation, SEC disappeared in only two of 35 patients in atrial fibrillation and in five of eight patients in sinus rhythm. Significant mitral regurgitation occurred in the two patients in atrial fibrillation. TEE detected left atrial thrombus in 14 patients. Thrombus was significantly associated with age, mitral valve area, and the severity of SEC. The latter was found to be an independent predictor of thrombus. Two patients in sinus rhythm had evidence of left atrial mechanical dysfunction. Both patients had left atrial SEC and one had thrombus in the appendage. It is concluded that SEC in patients with severe mitral stenosis is dependent on left atrial systolic function and peak systolic pulmonary vein velocity. It is not related to mitral valve area or anticoagulant therapy.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

PubMedDate not supplied

Haemodynamic response in soccer spectators: is Scottish football exciting?

OBJECTIVE: To determine the effect of watching a game of Scottish football on heart rate and blood pressure. DESIGN: Prospective study. SETTING: Two Scottish Premier League football grounds. SUBJECTS: 10 healthy men, each a supporter of one of two clubs. MAIN OUTCOME MEASURES: Systolic and diastolic blood pressure and heart rate at home, while walking, and during the match. RESULTS: Systolic blood pressure and heart rate were significantly higher when the men were watching the match than when they were at home. While they were watching the match, heart rate was maximal immediately after a goal had been scored by the supported team. CONCLUSION: The emotional stress invoked by Scottish football is associated with significant increases in heart rate and systolic blood pressure.

Blood Pressure↗

PubMedDate not supplied

Transseptal mitral balloon valvotomy in patients with atrial septal aneurysms.

Transthoracic and transoesophageal echocardiography (TTE, TEE) were performed in 130 consecutive patients referred for mitral balloon valvotomy. Atrial septal aneurysms were diagnosed by TTE and TEE in 2 and 3 patients, respectively. All 3 patients underwent mitral balloon valvotomy via the transseptal route. The foramen ovale was found to be patent in 2 of these patients, thus rendering puncture of the interatrial septum unnecessary. In the 3rd patient transseptal catheterisation was performed through the wall of the aneurysm itself. There were no significant complications in any of these patients. No left-to-right interatrial shunting could be demonstrated by oximetry in any of the 3 patients. Transoesophageal colour flow imaging showed trivial shunting in 2 patients and none in the 3rd. Transseptal mitral balloon valvotomy can be performed safely in patients with atrial septal aneurysms, especially in those with co-existent patent foramen ovale.

Adult↗

PubMedDate not supplied

[Problem of biological disponibility of digoxin].

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Digoxin↗