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Biomedical subjects

T R Thomas

Publications and source records attributed to T R Thomas.

At least 19 recordsLinked to original sources

Inferring articulation and recognizing gestures from acoustics with a neural network trained on x-ray microbeam data.

This paper describes a method for inferring articulatory parameters from acoustics with a neural network trained on paired acoustic and articulatory data. An x-ray microbeam recorded the vertical movements of the lower lip, tongue tip, and tongue dorsum of three speakers saying the English stop consonants in repeated Ce syllables. A neural network was then trained to map from simultaneously recorded acoustic data to the articulatory data. To evaluate learning, acoustics from the training set were passed through the neural network. To evaluate generalization, acoustics from speakers or consonants excluded from the training set were passed through the network. The articulatory trajectories thus inferred were a good fit to the actual movements in both the learning and generalization conditions, as judged by root-mean-square error and correlation. Inferred trajectories were also matched to templates of lower lip, tongue tip, and tongue dorsum release gestures extracted from the original data. This technique correctly recognized from 94.4% to 98.9% of all gestures in the learning and cross-speaker generalization conditions, and 75% of gestures underlying consonants excluded from the training set. In addition, greater regularity was observed for movements of articulators that were critical in the formation of each consonant.

Adult

Effect of breathing techniques on blood pressure response to resistance exercise.

Twenty novice male weight lifters performed resistance exercises using three different breathing techniques to determine the effects on blood pressure. Systolic and diastolic blood pressures were measured by an automated non-invasive method while subjects performed the single arm curl and double knee extension using the different breathing techniques. Performing the Valsalva manoeuvre (breath-holding) during either the single arm curl or double knee extension produced the highest blood pressure responses. Inhaling during the concentric phase of the exercise was associated with blood pressure elevations that were similar to the elevations observed with exhaling during the concentric phase. The heart rate response was slightly higher with inhalation. These results suggest that performing the Valsalva manoeuvre exaggerates the blood pressure response to resistance exercise. In addition, coupling inhalation with the concentric phase of the lift offers no cardiovascular advantage over coupling exhalation with the concentric phase of the lift.

Adolescent

Fat energy use and plasma lipid changes associated with exercise intensity and temperature.

The effect of 60 min of exercise at two intensities (50 and 60% VO2max) and temperatures (0 and 22 degrees C) on changes (delta) in plasma lipids [triglycerides (TG), glycerol (GLY), total cholesterol (TC), and HDL-cholesterol (HDL-C)] was examined. Subjects were 10 men aged 27 +/- 7 years (VO2max = 3.81 +/- 0.45 1 min, % fat = 12.2% +/- 7.1%). VO2 and respiratory exchange ratio results indicated that total energy and fat energy use were similar at the two temperatures. Changes in plasma volume (%delta PV) were different (P less than 0.05) at the two temperatures (22 degrees C: -2.3% vs 0 degrees C: 1.1%). Combining the data at each temperature revealed that the increases in concentrations were greater (P less than 0.05) at 22 degrees C (delta TG = 0.22, delta GLY = 0.20, delta TC = 0.14, delta HDL-C = 0.05 mmol l-1) vs 0 degrees C (delta TG = 0.10, delta GLY = 0.12, delta TC = 0.05, delta HDL-C = 0.02 mmol l-1). Combining the data for each intensity revealed that the increases in concentration were greater (P less than 0.05) at 60% VO2max for delta TG and delta HDL-C. The 60% VO2max/22 degrees C bout produced greater changes (P less than 0.05) than all other bouts for delta TC and delta HDL-C (0.21 and 0.08 mmol l-1, respectively). Only delta TG and delta GLY were greater at 22 degrees C when adjusted for %delta PV. These metabolic and plasma lipid results indicate that cold exposure does not act synergistically with exercise to further stimulate fat metabolism.

Adult

Resistance exercise program effects on abdominal function and physique.

The purpose of this study was to compare the effects of different abdominal exercise programs on abdominal muscular function and physique. Forty-five men and women (aged 18-26 yr) were randomly assigned to training using: (1) abdominal crunch (AC) weight machine; (2) steated incline (SI) weight machine; or (3) incline sit-up (ISU) exercise. Strength training occurred three times per week for 10 weeks. All groups improved in abdominal muscular strength and endurance. The ISU and AC group improved in muscular power (timed sit-up), while flexibility was maintained or increased in all groups. Abdominal skinfolds tended to increase and girths generally were unaltered by the abdominal exercise programs. These results suggest that abdominal weight machines or traditional incline sit-ups are effective in altering abdominal muscular function, but local abdominal exercise alone is unsatisfactory for reducing stomach skinfolds or girths.

Abdominal Muscles

Metabolic responses associated with four modes of prolonged exercise.

The purpose of this study was to compare energy expenditure and substrate utilization during 60 min of steady state-exercise at similar heart rates (HR) using four exercise modes: stationary cycle (C), rower (R), ski simulator (S), and treadmill (walking) (T). Five subjects (means age = 23 +/- 4 yr) performed 60 min of continuous exercise at 65% HR max on each of the four modes in random order. Total energy (TE) and fat energy (FE) expenditure were determined from VO2 and respiratory exchange ratio (RER). VO2 during exercise averaged 2.427 for C, 2.167 for R, 2.242 for S, and 2.420 l min-1 for T and were not significantly different by repeated measures ANOVO (p greater than 0.05). RER, TE, and FE also were not statistically different among exercise modes. However, walking and skiing tended to use more fat; the average 60 min cumulative exercise values were 960 for C, 871 for R, 1088 for S, and 1188 kJ for T. The rate of fat expenditure generally increased after 20 min on all modes. These results indicate that the energy expended at comparable relative HR's is similar for four aerobic exercise modes.

Adult

Dietary preparation and per cent fat measurement by hydrostatic weighing.

To examine if the dietary preparation for hydrostatic weighing (HW) alters the % fat measurement, seven men and three women (age 29 +/- 6, Males 11.7 +/- 7.3% fat and Females 24.1 +/- 5.4% fat, mean +/- SD) were assessed before and after three meals. On separate days and in random order, each subject (1) ate a salad with toppings (600 g) with small beverage, (2) ate two bean burritos and one bean tostada (900 g) with small beverage, and (3) drank 800 ml of carbonated beverage. The subject was reweighted 45 min after the meals and immediately after the beverage ingestion. Functional residual capacity was assessed simultaneously with underwater weight. Dependent t-tests indicated that body weight in air increased after each of the three means (Bean 0.78, Salad 0.92, Beverage 0.90 kg, all p less than 0.05), but underwater weights were unchanged. Following the salad, body density (1064.6 vs 1061.8 kg.m-3) and % fat (15.0 vs 16.3%, p less than 0.05) were significantly different pre-meal vs post-meal. Likewise, beverage ingestion resulted in decreased body density (1064.7 vs 1061.2 kg.m-3) and increased % fat (15.0 vs 16.5%, p less than 0.05). The bean meal did not cause a change in measured body density (1062.8 vs 1062.8 kg.m-3) or % fat (15.8 vs 15.8%). These results indicate that for the most accurate analysis, preliminary dietary preparation for HW should include food and beverage restriction.

Adipose Tissue

Response of HDL cholesterol, apoprotein A-I, and LCAT to exercise withdrawal.

The effect of short-term exercise withdrawal on plasma lipoproteins, apoprotein A-I (Apo A-I), and lecithin:cholesterol acyltransferase (LCAT) was studied in moderately trained lifestyle exercisers. Eight endurance-trained men, age 18-45 years (means = 29 years), withdrew from aerobic activity for 6 weeks, while an age and fitness-matched control group (n = 9) maintained normal exercise habits. A baseline period that included two blood samplings preceded the detraining intervention. Plasma total cholesterol (TCHOL), HDL cholesterol (HDL-C) and triglyceride (TG) levels were determined weekly. Other blood variables (HDL2-C, HDL3-C, Apo A-I, and LCAT), % fat, and aerobic capacity (VO2max) were measured pre-, mid-, and post-experiment. A two-way repeated measures analysis of variance (ANOVA) indicated that the 6-week exercise withdrawal period failed to elicit significant mean changes in any blood variable, % fat, or VO2max. Therefore, a short-term layoff from aerobic activity by moderately trained, chronic exercisers generally does not adversely affect the blood lipoprotein profile or aerobic capacity.

Adolescent

Fat utilization enhanced by exercise in a cold environment.

To study substrate utilization during cold temperature exercise, seven men dressed in shorts, T-shirts, and light gloves performed 60 min of continuous cycle ergometer exercise at -10 degrees C and 22 degrees C. The workload at both temperatures represented 66% of the cycle-measured maximal heart rate. Oxygen consumption and respiratory exchange ratio (RER) were measured at rest and during 60 min of exercise. Rates of total and fat energy utilization (kJ X min-1) during exercise were calculated from VO2 and RER. A two-factor repeated measures analysis of variance indicated that at rest oxygen consumption averaged 56% higher and RER 5% lower at -10 degrees C. During exercise, oxygen consumption averaged 10% higher (P less than 0.05), and RER averaged 2% lower (P less than 0.05) at -10 degrees C. The rates of total energy use (mean +/- SD = 39.3 +/- 1.2 vs 35.7 +/- 1.3 kJ X min-1; P less than 0.05) were significantly higher at -10 degrees C than at 22 degrees C. In addition, the rate of fat use increased significantly in both groups after 30 min of exercise. The cumulative total energy expenditure for 60 min of exercise was 13% higher (2379 +/- 308 vs 2110 +/- 415 kJ; P less than 0.05 and the cumulative fat expenditure was 35% higher (979 +/- 209 vs 724 +/- 184 kJ: P less than 0.05) in the cold environment. These results indicate that a cold environment can significantly enhance fat utilization during endurance exercise.

Adipose Tissue

Effects of interval and continuous running on HDL-cholesterol, apoproteins A-1 and B, and LCAT.

The purpose of this study was to examine the effect of interval and continuous exercise programs on plasma lipoproteins, apoproteins, and lecithin: cholesterol acyltransferase (LCAT). Thirty-six college male students (age 18-25 yrs.) were randomly assigned to a 5 mile continuous exercise group, 4 minute interval (1:1, work:rest), 2 minute interval (1:1-1/2, work:rest), or control. Workloads were equated by kcal expenditure/workout. The training groups exercised for one hour three times a week for 11 weeks. Neither interval or continuous exercise programs significantly altered plasma total cholesterol, high density lipoprotein cholesterol (HDL-C), apoprotein A-1 (Apo A-1), apoprotein B (Apo B), or LCAT. Posttest maximal oxygen consumption was significantly higher than pretest for the 4 minute interval and 5 mile continuous groups. Thus continuous exercise and long interval programs resulted in gains in aerobic capacity, but none of the training programs were effective in altering the plasma lipoproteins or apoproteins investigated.

Adolescent

Fatty acid pattern and cholesterol in skeletal muscle of men aged 22 to 73.

In order to examine the relationship between fatty acid distribution of skeletal muscle membranes and age, a needle biopsy was performed on the vastus lateralis muscle of 20 healthy, non-obese males, ranging in age from 22 to 73 years. The muscle sample was homogenized, centrifuged at 100,000 x g, and the resulting pellet was saponified and acidified. The fatty acids and cholesterol were removed by a single hexane extraction and analyzed by gas--liquid chromatography with flame ionization detection. All subjects regardless of age had no consistent differences in the fatty acid profiles and cholesterol composition in the tissue. Correlation coefficients indicated no significant relationship between the age of the individual and any of the analyzed lipids. The results of this study indicated that aging may not be reflected by gross changes in the composition of structural lipids in the cell.

Adult

A simple inexpensive method for estimating underwater weight.

A description is given of a simple, inexpensive and versatile method for estimating underwater weight. The use of a portable stock tank allows the determination of % Fat by underwater weighing without requiring a swimming pool, built-in tank, or special facility. Twenty-eight college students were weighed on two separate testing sessions 24-48 hours apart. Ten trials were performed at each session. The mean of the last five trials was used in determining underwater weight. The test-retest reliability coefficient was high, r = 0.98, and most of the successive trial correlations were above 0.99. The mean % Fat for the women (N = 9) was 22.2 +/- 5.9 and for the men (N = 19) was 13.7 +/- 5.1.

Adipose Tissue

Fatty acid profile and cholesterol in skeletal muscle of trained and untrained men.

To compare the fatty acid distribution and cholesterol composition in trained and untrained isolated skeletal muscle membranes, a needle biopsy was performed on the vastus lateralis of the 10 distance runners and 10 sedentary men. The muscle sample was homogenized and centrifuged at 100,000 X g; the resulting pellet was analyzed by gas-liquid chromatography for individual fatty acids and cholesterol. The percentage of palmitic acid was significantly lower in the trained muscle tissue. Samples from the distance runners also tended to have a more frequent appearance of linolenic and eicosatrienoic acids, longer fatty acid hydrocarbon chains, and lower cholesterol concentration. It was concluded that trained muscles have an increased membrane fluidity which could beneficially affect the activity of membrane-bound enzymes and active transport. Longer chain length in the membrane lipids may be a means of producing an inner membrane cohesiveness in muscles of trained individuals.

Adult

The effects of antacids on enteric-coated salicylate preparations.

A volunteer study was undertaken in which the effect of the co-administration of therapeutic doses of aluminium hydroxide and magnesium trisilicate on the excretion of aspirin derived from enteric-coated preparations was studied. A significant alteration in the pattern of salicylate excretion was seen, but the mechanism of the interaction cannot be deduced from the present study. It was concluded that the interaction was of potential therapeutic importance, and further studies based on this pilot investigation have been initiated.

Adult