Self assessment.
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Acquired Immunodeficiency Syndrome↗
Biomedical subjects
T R Wade
Publications and source records attributed to T R Wade.
Subacute cutaneous lupus erythematosus in Iceland.
Identification of patients with subacute cutaneous lupus erythematosus (SCLE) in Iceland was performed by means of a survey based on the histopathologic or immunofluorescent diagnosis of lupus erythematosus. Respondents underwent serologic studies, gave histories, and, dependent upon the latter, were examined. The resultant proportional rate of patients with SCLE approached 10% of all lupus erythematosus cases.
Antibodies, Antinuclear↗
Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology.
Malignant acanthosis nigricans is usually associated with adenocarcinomas of the digestive tract. The lesions of acanthosis nigricans commonly run a parallel course to the associated malignancy, producing hyperpigmented, roughened plaques on the skin and, sometimes, verruca-like papules on the oral mucosa. The clinical differences between cutaneous and oral acanthosis nigricans are mirrored by the marked differences in the histopathology. Because oral acanthosis nigricans is uncommon, recognizing histologic features may be difficult. The oral lesions have a true acanthosis and epithelial papillary hyperplasia while the cutaneous forms show slight irregular acanthosis that alternates with areas of epidermal atrophy and dermal papillomatosis.
Acanthosis Nigricans↗
The histology of malignant melanoma.
A brief review of the histology of malignant melanoma is presented, including various prognostic indicators of the biologic behavior of this neoplasm. Reproducible criteria are outlined in an attempt to provide for a more accurate diagnosis and subsequent treatment of this life-threatening disease.
Diagnosis, Differential↗
Nail pathology in histiocytosis X.
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Histiocytosis, Langerhans-Cell↗
The effects of resin of podophyllin on condyloma acuminatum.
The effects of resin of podophyllin on lesions of condyloma acuminatum have posed problems to pathologists who sought to differentiate them histologically from squamous cell carcinoma in situ. The most striking histologic changes in lesions of condyloma acuminatum following application of resin of podophyllin occur within the first 48 hours. They are pallor of the epidermis secondary to both intracellular and intercellular edema, numerous necrotic keratinocytes in the lower half of the epidermis, and a marked increase in the number of mitotic figures there. Within the edematous papillary dermis, there is a scattered infiltrate of lymphocytes, histiocytes, and neutrophils. The absence of nuclear atypia, multinucleated keratinocytes, and dyskeratotic cells, and the presence of the orderly sequence of maturation of keratinocytes within the epidermis permit histologic differentiation of podophyllin-treated condyloma acuminatum from true squamous-cell carcinoma in situ. The acute histologic changes induced by podophyllin begin to wane by 72 hours after the resin has been applied. At this time, necrotic keratinocytes are found mostly within the upper portion of the epidermis and few mitotic figures are seen. By 1 week after application of podophyllin there are virtually no histologic abnormalities within the epidermis.
Adult↗
Restoration of Trichophyton mentagrophytes growth in medium depleted of metals by chelation: importance of iron.
The present study examined the requirement of Trichophyton mentagrophytes ATCC-18748 for iron. Nutrient broth depleted of iron by the chelating cation exchange resin Chelex-100 did not support the growth of T. mentagrophytes beyond germ tube formation. The soluble chelate of iron, ferric ammonium citrate, restored the capacity of the chelated medium to support fungal growth in proportion to the amount of iron added. Ferric chloride, which rapidly becomes insoluble at neutral pH, was not effective in the medium. The soluble salts of cobalt, chromium, copper, manganese, nickel, and zinc individually did not replace the requirement for iron. A method for defining the iron requirement based upon utilization of iron from ferric ammonium citrate is described. These data indicate that the growth of T. mentagrophytes ATCC-18748 is iron-dependent, which is consistent with the hypothesis that serum transferrin inhibits dermatophyte growth by the mechanism of iron deprivation.
Chelating Agents↗
Cornoid lamellation. A histologic reaction pattern.
Cornoid lamellation is a constant histologic marker of porokeratosis in its many variants. This histologic appearance, heretofore thought to be pathognomonic of and restricted to porokeratosis alone, has also been found by us in a variety of other conditions. Cornoid lamellation is, therefore, analogous to the histologic findings of focal acantholytic dyskeratosis, epidermolytic hyperkeratosis, and follicular mucinosis as a distinctive histologic reaction pattern that reflects disordered progression of epidermal cells to cornification.
Epithelium↗
Pruritic urticarial papules and plaques of pregnancy.
We report an intensely pruritic cutaneous eruption that occurs in the third trimester of pregnancy. The clinical manifestations include erythematous urticarial papules and plaques that begin on the abdomen and spread to involve the thighs and occasionally the buttocks and arms. This dermatosis appears to be clinically distinct from previously described pruritic eruptions occurring in pregnancy. Biopsy specimens of the lesions show two histological patterns. We propose that this entity be termed "pruritic urticarial papules and plaques of pregnancy (PUPPP)".
Abdomen↗
Multiple penile chancres. An atypical manifestation of primary syphilis.
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Adult↗
The many faces of seborrheic keratoses.
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Aged↗
Irritant and allergic reactions to topically applied Micatin cream.
Miconazole nitrate (Micatin cream) is a potent antifungal agent. Few side effects have been reported with topical application. We report on 10 patients who exhibited an intolerance to topical use of this drug. Most of the reactions were irritant in nature but in two instances, an allergic contact dermatitis was observed. Patch tests were positive to the cream base.
Dermatitis, Atopic↗
Bowenoid papulosis of the genitalia.
We report 34 cases of bowenoid papulosis of the genitalia. In each case, the patient had numerous reddish brown or violaceous papular lesions, some distinctly verrucoid, situated on the genitalia. Although clinically the lesions invariably appeared benign, histologic examination of specimens from the genital lesions in each patient showed changes of squamous cell carcinoma in situ. Many of the patients gave a history of preceding viral lesions on the genitalia. Therapy in all cases was conservative but thoroughly ablative. We view bowenoid papulosis as a new entity whose biologic behavior if untreated is as yet unknown.
Adolescent↗
Intravenous miconazole therapy of mycotic infections.
The efficacy and safety of intravenously administered miconazole nitrate was examined in eight patients with the following infections: cutaneous North American blastomycosis (one), extensive dermatophytosis(one), and chronic mucocutaneous candidiasis (six). Mycologic assessment included direct examination for fungal elements, fungal culture, and histopathology. Laboratory evaluations were performed before and at regular intervals during the study. The total miconazole nitrate dosage, which was administered over a seven- to 32-day period, ranged from 4.0 to 46.8 g. Follow-up examinations extended from two to 15 months. Excellent results were obtained in five patients and fair results in three. No renal, cardiac, hepatic, or hematopoietic toxicity was observed. Other side effects, however, necessitated premature cessation of therapy in four patients. Overall, intravenously administered miconazole is an effective antifungal agent for these cutaneous infections.
Adolescent↗