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Biomedical subjects

T Ramstad

Publications and source records attributed to T Ramstad.

24 records · Page 2Linked to original sources

Development and validation of a procedure for the determination of minoxidil in hair-regrowth formulations using two variants of capillary zone electrophoresis.

A high performance capillary electrophoresis method was developed and validated for purity assessment of minoxidil bulk drug and for determination of minoxidil in Rogaine. The principal use of the method was in analyzing illicit minoxidil-containing hair-regrowth samples. Although validated for Rogaine, the procedure proved equally viable on illicit minoxidil-containing preparations. The developed method fulfilled the goal of providing an orthogonal technique to HPLC for confirmation of the presence of minoxidil in these imitations. The method was validated on two instruments, one utilizing EK injection, the other gravity injection. It is selective for minoxidil, which is separated from known process impurities and the single degradation impurity. Validation figures of merit for linearity/recovery (accuracy) and precision were in accordance with current expectations for method validation.

Electrophoresis, Capillary↗

Long-term prosthodontic follow-up and revisional treatment of patients with cleft lip and palate: case presentation.

PURPOSE: The purpose of this article is to draw attention to the need for regular life-long follow-up care of cleft lip and palate patients to maintain adequate masticatory function, speech, and esthetics, thereby supporting psychosocial function. MATERIALS AND METHODS: Initial and revisional prosthodontic treatments over a period of 32 years in a patient with a bilateral cleft lip and palate are described. RESULTS: Despite an initial dentition of poor health and prognosis and suboptimal patient cooperation, it was possible to arrive at an improved clinical and radiologic state of oral health by the end of the observation period. CONCLUSION: Regular life-long prosthodontic follow-up with adequate maintenance and revisional treatments should be regarded as an essential part of the long-term care for subjects with clefts.

Adult↗

The effect of alveolar bone grafting on the prosthodontic/reconstructive treatment of patients with unilateral complete cleft lip and palate.

This study compared the effect that the introduction of mixed dentition alveolar bone grafting and subsequent orthodontic treatment has had on the prosthodontic/reconstructive habilitation of patients with unilateral cleft lip and palate. Two groups, each consisting of 40 consecutive patients with unilateral cleft lip and palate, were compared at the end of their dental treatment. In the group treated prior to the advent of bone grafting, all subjects received a fixed partial prosthesis in the cleft area, and a total of 87 abutment teeth were prepared for complete coverage crowns. In contrast, in the group of patients for whom the alveolus was restored by bone grafting, it was possible to obtain a complete dental arch without prosthodontic intervention in 36 patients (90%). Thirteen subjects in the bone grafting group had the crown anatomy of anterior teeth modified using resin composite or resin-bonded porcelain veneers. Two patients had a premolar transplanted to the anterior region of the dental arch. On average the dental treatment was completed 3 years earlier in the bone grafting group. Thus, alveolar bone grafting with subsequent orthodontic treatment, together with advances in dental materials, have markedly reduced the need for prosthodontic procedures and have also allowed the completion of the dental treatment at an earlier age.

Adolescent↗

A definition of prosthetic dentistry.

PURPOSE: A more precise and up-to-date definition of prosthetic dentistry is warranted. The aim of the present review is to present a new core definition of the discipline on the basis of a discussion of existing definitions. MATERIALS AND METHODS: Clinical textbooks in prosthetic dentistry and dental implantology, as well as medical and dental glossaries were reviewed. RESULTS: Two main categories of definitions of prosthetic dentistry were identified: first, definitions that emphasized the technologic aspects of the discipline, i.e., the fabrication of prostheses; and second, definitions that incorporated some reference to the objectives or aims of prosthetic treatment, i.e., the restoration of one or more aspects of oral function. Slightly more than half of the citations contained such aim-related references, and this aspect tended to be most pronounced in recent publications. CONCLUSION: The following definition is ventured: prosthodontics is the discipline of dentistry concerned with the consequences of congenital absence or acquired loss of oral tissues and with the methods for and assessment whether more good than harm is done by inserting artificial devices made from alloplastic materials.

Humans↗