PubMed Health⌕ Search

Biomedical subjects

T Rand

Publications and source records attributed to T Rand.

At least 37 records · Page 2Linked to original sources
PubMed1999

Comparison of low field (0.2T) and high field (1.5T) MR imaging in the differentiation of torned from intact menisci.

PURPOSE: To evaluate the usefulness of a low field MRI system (0.2T; Esaote, Biomedica) for the evaluation of meniscal tears with regard to anatomic site, and to compare the results with findings from a high field unit (1.5T; Siemens, Erlangen). MATERIAL AND METHODS: MRI was performed in 25 patients in a low field (0.2T; Esaote, Biomedica), and a high field (1.5T; Siemens, Erlangen) MRI unit. The images were analyzed for the presence or absence of meniscal tears and the confidence of decision making. Results were further analyzed for the number of identical and unidentical findings on both imaging modalities. In seven patients, arthroscopy was performed and the findings compared with the results from MR imaging. Statistical analysis was performed by chi 2-test, Wilcoxon test and Friedman analysis. RESULTS: Qualitative evaluation of the level of confidence in decision making was significantly superior on high field strength images. When comparing the evaluations from both image modalities in 21 of 25 patients (84%), the diagnosis concerning the presence or absence of meniscal tears was identical. CONCLUSION: Although low field MR imaging might offer diagnostic potential concerning the presence or absence of meniscal tears, the level of confidence in decision making is significantly superior with high field strength imaging, probably reflecting the higher conspicuity of lesions from high field strength units.

Adult↗
PubMed1999

Magnetic resonance imaging in hemophilic children: value of gradient echo and contrast-enhanced imaging.

The purpose of this study was to determine the value of Gradient Echo imaging for the evaluation of cartilage (3D fatsat) and blood products (2D Hemoflash), and the use of contrast enhanced SE imaging for the evaluation of synovial changes, in comparison to the clinical evaluation of children with hemophilia A. We investigated 21 joints in 16 patients with evidence of hemophilia A (mean age 11.3+/-2.1 years). In all patients, clinical examination, plain film radiographs, and MR evaluation were performed magnetic resonance imaging (MRI) was performed by using sagittal T1 SE and T2 SE images, as well as 3D fatsat GE and 2D GE images. Axial and sagittal T1 weighted SE images were obtained before and after contrast application. Findings from the clinical examination and MR imaging, regarding the evaluation of blood, synovia, and cartilage were compared. Clinical examination revealed evidence of a bleeding episode in 12 joints (57.1%), whereas MRI revealed evidence of blood or blood products in 15 joints (71.4%). Clinical investigations, including bleeding scores, pain scores, and physical examination scores did not correlate with MR findings. Due to the MR findings in 6 of 16 patients, therapeutic management was changed from on demand to prophylactic therapy. MR imaging with gradient echo and contrast-enhanced sequences is more sensitive than clinical examination for the detection of blood products in children with hemophilia. Its ability to demonstrate potentially early stages of cartilage or synovial alterations might assist in therapy planning. Clinical scores might underestimate effects of hemophilia.

Ankle Joint↗
PubMed1999

MRI visualization of proteoglycan depletion in articular cartilage via intravenous administration of Gd-DTPA.

The effect of intravenous administration of gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) on MR images was studied in vitro, using pathologic osteochondral specimens removed during surgery for total endoprosthesis, and in vivo, on a group of volunteers. In ex vivo specimens, lesions of different shape having lower T1 were detected which corresponded to areas with depleted proteoglycans found histologically. In vivo experiments on young volunteers showed that the time course of cartilage enhancement was different for different anatomies. The time for maximum enhancement ranged from 45 min for the ventral femoral condyle to 270 min for patellar cartilage.

Adult↗
PubMed1999

Magnetic resonance arthrography (MRA) in the postoperative shoulder.

To evaluate changes in capsular mechanisms and the labroligamentous complex with magnetic resonance arthrography (MRA) after shoulder surgery and to establish possible criteria for the expected post-operative appearance of the shoulder. MRA of the shoulder was performed in 16 patients, before and 6 months after undergoing arthroscopic surgery for recurrent unidirectional dislocation. MR studies were performed after application of a constant amount of contrast solution (2 mmol Gd-DTPA). Axial and coronal oblique T1-weighted images were obtained with and without fat suppression techniques. Anterior (a) and posterior (p) capsular distances were measured, and the p/a ratio was established. Capsule thickness, capsular leaking, estimation of the volume of the axillary recess, appearance of the glenohumeral ligaments, and evidence of labral lesions were compared on pre- and postoperative images. Mean anterior capsular distance (a) decreased from 9.73 +/- 1.03 mm preoperatively to 5.27 +/- 2.49 mm postoperatively, whereas dorsal capsular distance (p) increased from 6.13 +/- 2.36 to 8.93 +/- 2.37. The p/a ratio increased from 0.64 +/- 0.25 to 2.36 +/- 2.54 (p = 0.007). Capsular leaking was suspected preoperatively in seven patients, but was not evident postoperatively. Capsular thickness and the estimated volume in the axillary recess did not change significantly. Contrast extension into pre-existent labral tears (nine patients) decreased or were not evident postoperatively. Changes in the appearance of the glenohumeral ligaments were found in six patients. Changes in capsular distances might be indicative of a decreased capsular laxity and could be a valuable criterion in the evaluation of the postoperative shoulder. Postoperative follow-up of labral tears is demonstrated by a decrease in contrast extension into or under a tear. Reactive capsular thickening or scar tissue formation can be reactive or preexistent. Changes in ligaments might be secondary to surgery. MRA may be helpful in the reevaluation of patients with suspected recurrent instability.

Adolescent↗
PubMed1999

In vivo development of brain phosphocreatine in normal and creatine-treated rabbit pups.

To study the effects of creatine (Cr) on brain energy metabolism and on hypoxia-induced seizures, 5- to 30-day-old rabbit pups were given subcutaneous Cr (3 g/kg) for 3 days before exposure to 4% O2 for 8 min. In saline-treated controls, hypoxic seizures were most frequent at 15 days (80% of pups) and 20 days (60%) of age. Seizures were prevented at 15 days and reduced 60% at 20 days in Cr-treated pups. In surface coil-localized brain 31P nuclear magnetic resonance spectra, with signal from both cerebral gray (GM) and white (WM) matter, the phosphocreatine (PCr)/nucleoside triphosphate (NTP) ratio doubled between 5 and 30 days of age in controls. In all Cr-injected pups, brain PCr/NTP increased to values seen in 30-day-old controls. When spectra were acquired in predominantly GM and WM slices in vivo, the PCr/NTP ratio was very low in GM at 5 days but reached adult levels by 15 days in controls. In WM, the ratio increased steadily from 5 to 30 days of age. In Cr-injected pups, PCr/NTP increased to mature levels in WM and in GM at all ages. In conclusion, hypoxic seizures occur midway in the time course of brain PCr/NTP increase in rabbit pups as previously described in rat pups. In both altricial pups, systemic Cr increases brain PCr/NTP ratio and prevents hypoxic seizures. These results suggest that mature levels of PCr and/or Cr in brain limit EEG activation either directly or indirectly by preventing hypoxic metabolic changes.

Adenosine Triphosphate↗
PubMed1999

Importance of subchondral bone to articular cartilage in health and disease.

The almost absolute barrier to diffusion of nutrients between articular cartilage and subchondral bone does not exist. These anatomic regions represent a functional unit. Repetitive overloading in degenerative disease leads primarily to lesions in the subchondral region (including vessels), which in turn impede flow of nutrition to articular cartilage. As a result, in degenerative joint disease the subchondral region shows reactive enhanced vascularization and heightened metabolism with insufficient repair. In aging, however, vascularization and metabolism are decreased; no repair takes place. In many cases, MRI allows visualization of these subchondral abnormalities. It also demonstrates the basic similarities of degenerative osteoarthritis, osteochondritis dissecans, and avascular necrosis. These different entities may have the same basic etiology but with different disease severity.

Arthrography↗
PubMed1999

The postoperative shoulder.

Because disability and pain may persist or recur after shoulder surgery, visualization of the postoperative shoulder before further treatment is of great interest. Postoperative status is reevaluated most frequently after rotator cuff repair, capsulorrhaphy in patients with chronic instability, and acromioplasty, where postoperative symptoms are clinically difficult to distinguish from rerupture or inadequate surgical results. Postoperative evaluation or follow-up after surgical treatment of tumors or surgical repair of shoulder injuries are other potential indications. Whereas surgical procedures for osseous components primarily will be evaluated by plain film radiographs, magnetic resonance imaging is a valuable tool for other sites of surgical treatment, such as soft-tissue components, with further potential indication for magnetic resonance arthrography. This article focuses on normal and abnormal postoperative findings in the shoulder, with emphasis of magnetic resonance imaging, and discusses specific findings based on magnetic resonance arthrography.

Acromion↗
PubMed1999

Magnetic resonance imaging of the postoperative knee.

Due to the recent development of arthroscopic techniques in meniscal surgery and anterior cruciate ligament reconstruction, an increasing number of postoperative patients are referred for a magnetic resonance examination of the knee because of recurrent injury. Contrary to the nonoperative patient, T2-weighted sequences and, in unequivocal cases, magnetic resonance arthrography play the most important role in the evaluation of a possible meniscal retear. In patients with anterior cruciate ligament reconstruction, the changes of the magnetic resonance appearance of the anterior cruciate ligament graft during the first year after surgery must be considered in the diagnosis of retears. Recent developments in articular cartilage defect repair and the possible role of magnetic resonance imaging in the follow-up are discussed.

Anterior Cruciate Ligament↗
PubMed1999

Germicidal ultraviolet irradiation in air conditioning systems: effect on office worker health and wellbeing: a pilot study.

OBJECTIVES: The indoor environment of modern office buildings represents a new ecosystem that has been created totally by humans. Bacteria and fungi may contaminate this indoor environment, including the ventilation systems themselves, which in turn may result in adverse health effects. The objectives of this study were to test whether installation and operation of germicidal ultraviolet (GUV) lights in central ventilation systems would be feasible, without adverse effects, undetected by building occupants, and effective in eliminating microbial contamination. METHODS: GUV lights were installed in the ventilation systems serving three floors of an office building, and were turned on and off during a total of four alternating 3 week blocks. Workers reported their environmental satisfaction, symptoms, as well as sickness absence, without knowledge of whether GUV lights were on or off. The indoor environment was measured in detail including airborne and surface bacteria and fungi. RESULTS: Airborne bacteria and fungi were not significantly different whether GUV lights were on or off, but were virtually eliminated from the surfaces of the ventilation system after 3 weeks of operation of GUV light. Of the other environmental variables measured, only total airborne particulates were significantly different under the two experimental conditions--higher with GUV lights on than off. Of 113 eligible workers, 104 (87%) participated; their environmental satisfaction ratings were not different whether GUV lights were on or off. Headache, difficulty concentrating, and eye irritation occurred less often with GUV lights on whereas skin rash or irritation was more common. Overall, the average number of work related symptoms reported was 1.1 with GUV lights off compared with 0.9 with GUV lights on. CONCLUSION: Installation and operation of GUV lights in central heating, ventilation and air conditioning systems of office buildings is feasible, cannot be detected by workers, and does not seem to result in any adverse effects.

Adult↗
PubMed1999

Ligaments and tendons of the ankle. Evaluation with low-field (0.2 T) MR imaging.

PURPOSE: To investigate the value of MR imaging using a low-field imaging unit (0.2 T) for the evaluation of ligaments and tendons of the ankle. MATERIAL AND METHODS: Twelve ankle specimens were studied using low-field MR imaging (0.2 T). The Achilles tendon, the tibialis posterior tendon, and the lateral collateral ligaments were evaluated for the presence of degenerative changes and partial and complete tears. Visibility and overall image quality were analyzed by qualitative evaluation. RESULTS: Low-field MR images of the 24 tendons were interpreted as normal in 11 cases, showing degenerative changes in 9 cases and a partial tear in 1 case. Visualization was regarded as not sufficient for a diagnosis in 3 cases. Of the 36 ligaments, 14 were regarded as normal while degenerative changes were seen in 5 cases and a tear in 2 cases. In 13 cases, no diagnosis could be established, and in 2 cases only a probable diagnosis was established. The best overall quality was obtained with the use of T1 spin-echo (680/20/4) and T2 multi-echo (3000/40/1) images. CONCLUSION: Optimized protocols for examination of the ankle using low-field MR imaging may allow evaluation of the Achilles and tibialis posterior tendons, but these protocols may not be as useful for diagnosing ligamentous changes.

Achilles Tendon↗
PubMed1999

[Chronic diseases of the ankle joint].

The etiology of chronic diseases of the ankle joint comprises a wide spectrum including chronic inflammatory processes and chronic degenerative, tumorous and neuropathic processes, as well as some specific syndromes based on chronic changes of the ankle joint. Of the inflammatory processes, chronic juvenile arthritis (JVC) is the most common disease. However, also Reiter disease, psoriasis or chronic monoarthritid diseases such as gout, as well as granulomatous diseases (tuberculosis, sarcoidosis) and fungal infections, may affect the ankle joint in a chronic course. Chronic degenerative changes are usually secondary due to abnormal positioning of the joint constituents or repetitive trauma. Neuropathic changes, as frequently seen in the course of diabetes, present with massive osseous destruction and malposition of the articular constituents. Chronic osseous as well as cartilaginous and synovial changes are seen in hemophilic patients. Chronic traumatic changes are represented by pigmented villonodular synovitis (PVNS), and chondromatosis, both with a predilection for the ankle joint. Due to the possibilities of magnetic resonance imaging (MRI), diagnosis of chronic ankle changes includes chronic ligamentous, tendinous and soft tissue changes. With the use of MRI, specific syndromes can be defined which particularly affect the ankle joint in a chronic way, such as the os trigonum syndrome, the anterolateral impingement syndrome and the sinus tarsi syndrome. Nevertheless, plain film radiographs are still the basic element of any investigation. MRI, however, can be potentially used as a second investigation, saving an unnecessary cascade of investigations with ultrasound and CT. The latter investigations are used only with very specific indications, for instance CT for subtle bone structures and sonography for a limited investigation of tendons or evaluation of fluid. Particularly due to the possibilities of MRI and the development of special gradient-echo imaging or high-resolution coils, the investigation of the ankle joint still offers a wide spectrum of innovation for the next years, which is particularly enforced by the increasing demand for specific diagnosis of chronic diseases in orthopedic medicine.

Adolescent↗
PubMed1998

MR imaging in shoulder trauma. Value of STIR images.

PURPOSE: To determine the adequacy of MR standard protocols by analyzing conventional T1- and T2-weighted SE sequences, and to evaluate the usefulness of additional fat-suppressed (STIR) images in shoulder trauma. MATERIAL AND METHODS: Paracoronal T1-weighted, T2-weighted, SE, and STIR images were obtained on a 0.5 T superconductive system in 25 patients with shoulder trauma. In a separate evaluation of T1/T2 images and a combined evaluation of T1/T2 SE- and STIR images, we compared the number of patients with evidence of Hill-Sachs lesions, bone bruises, and/or rotator-cuff lesions. RESULTS: Compared to the combined evaluation of T1/T2 and STIR images, the separate evaluation of T1/T2 SE images revealed identical results for rotator-cuff lesions and Hill-Sachs lesions, but different results for the bone bruises in the area of the major tubercle. CONCLUSION: Occult fractures of the major tubercle, indicated by areas of bone bruising, might be missed with MR using conventional SE images. We recommend the use of additional paracoronal fat-suppressed sequences in patients with clinically suspected lesions and equivocal findings on plain radiographs and on standard SE sequences.

Adult↗
PubMed1998

Low-field magnetic resonance imaging (0.2 T) of tendons with sonographic and histologic correlation. Cadaveric study.

RATIONALE AND OBJECTIVES: The authors evaluate the role of low-field strength magnetic resonance imaging (MRI) compared with sonography in the evaluation of degenerative changes of tendons, with histologic correlation, based on investigations of horse cadavers. METHODS: Low-field MRI and sonography was performed in 42 hours specimens for the evaluation of tendons and ligaments. Magnetic resonance imaging included sagittal and axial T1-weighted, T2-weighted, and gradient echo images. Sonography and MR images were evaluated for degenerative changes or tears and the findings were correlated with the histologic results. RESULTS: Using histologic findings as a gold standard, the accuracy for the sonographic evaluation was 65.9%, sensitivity was 16.7%, and specificity was 100%. The corresponding data for low-field MR imaging were 70.5% accuracy, 44.4% sensitivity, and 88.5% specificity. CONCLUSIONS: Low-field MRI investigation allows more accurate staging of tendinous changes than sonography. It is more reproducible and potentially includes the advantages of the combined evaluation of bones, ligaments, and soft tissue.

Animals↗
PubMed1998

MR imaging of the inner ear and cerebellopontine angle: comparison of three-dimensional and two-dimensional sequences.

OBJECTIVE: The aim of the study was to compare the ability of three-dimensional (3D) T2-weighted turbo spin-echo and gadolinium-enhanced 3D T1-weighted gradient-echo sequences with two-dimensional (2D) T2-weighted turbo spin-echo and gadolinium-enhanced T1-weighted spin-echo sequences to reveal anatomic and pathologic structures of the inner ear and cerebellopontine angle. SUBJECTS AND METHODS: Thirty-one patients underwent axial 2D T2-weighted turbo spin-echo and 3D T2-weighted turbo spin-echo MR imaging, axial and coronal 2D T1-weighted spin-echo MR imaging before and after i.v. injection of gadopentetate dimeglumine, and gadolinium-enhanced axial 3D T1-weighted gradient-echo MR imaging. The visualization of anatomic and pathologic structures on the different sequences was evaluated. Statistical analysis was performed from the data obtained from the visual evaluation of the anatomic structures on the different sequences. Signal-to-noise and contrast-to-noise ratios were calculated for the gadolinium-enhanced 3D T1-weighted gradient-echo and 2D T1-weighted spin-echo sequences, and statistical evaluation was performed. RESULTS: The 3D sequences enabled excellent visualization of 94% of all evaluated anatomic structures, and the 2D sequences enabled excellent visualization in only 3% of these structures. Pathologic structures were revealed in all cases by one or both of the 3D sequences. Diagnosis in all patients could be made by using the combination of the 3D T2-weighted turbo spin-echo and the gadolinium-enhanced 3D T1-weighted gradient-echo sequences. However, the 2D sequences failed to show pathologic structures in three patients. We found a significant statistical difference for the visualization of anatomic structures with the 3D and 2D sequences (p < .0001) and no significant statistical difference for the signal-to-noise and contrast-to-noise ratios with the 3D T1-weighted gradient-echo and 2D T1-weighted spin-echo sequences. CONCLUSION: The 3D sequences revealed anatomic structures significantly better than did the 2D sequences and showed pathologic structures considerably more often than did the 2D sequences in all patients. MR imaging of the inner ear and cerebellopontine angle performed with 3D T2-weighted turbo spin-echo and gadolinium-enhanced 3D T1-weighted gradient-echo sequences provided the most accurate imaging leading to diagnosis in cases of abnormality.

Adult↗
PubMed1998

[Diagnostic reliability of 0.2 Tesla dedicated MRI low-field strength equipment in traumatology].

Anatomical dedicated low-field-strength MR imaging (non-whole-body-systems) has been developed for examinations of the peripheral joints. It has several advantages compared to high-field-strength MR imaging (whole-body-systems). The dimensions are small, the noise is not as bad as in whole body systems and people do not suffer of claustrophobic attacks. However, our results of a prospective blinded study in 56 patients with three different kinds of peripheral joint injuries demonstrated that the 0.2 T dedicated system showed a significant lower rate of diagnostic accuracy compared to middle and high-field-strength MR imaging and scored with obvious lower image quality ratings.

Adolescent↗
PubMed1997

[MRI on low-field tomography systems (0.2 Tesla). A quantitative comparison with equipment of medium-field strength (1.0 Tesla)].

AIM OF THE STUDY: Using phantom studies, a dedicated low-field MR system with 0.2 T and a whole-body MR-scanner with 1.0 T were compared. METHODS: A spin-echo sequence was performed on the 0.2-T MR unit using the knee coil and on the 1.0-T MR unit with the head coil. In a water-filled phantom, signal-to-noise ratios (SNR) were calculated and contrast measurements on gels with well-defined relaxation times were obtained and compared to nominal relaxation times. Measurements of T1 and T2 relaxation times on the low-field system were compared to the 1.0-T unit. As a parameter for geometrical image quality, magnetic field distortions were calculated. In theory, influence of field strength and and receiver bandwidth on the minimal echo time and on chemical shift artifacts were calculated. RESULTS: The SNR was 63.2 on the 0.2-T and 179.6 on the 1.0-T MR unit (difference factor 3, against a theoretical difference of 5-16). Relaxation times on the low-field system were significantly (around 40-50%) lower. Measurements of contrast were similar on both systems. On the low-field system geometrical distortions of several pixels were recorded. The minimal echo time on the low-field system was 21.3 ms with the low receiver bandwidth and 4.3 ms on the 1.0-T MR unit. The amount of chemical shift artefacts was the same on both systems. DISCUSSION: On low-field MR systems SNR is markedly improved by small read-out gradients and a low receiver bandwidth (factor 3 vs 5-16 in comparison with the 1.0-T MR unit). However, an optimal homogeneous magnetic field is required, since inhomogeneities may create severe geometrical distortion.

Artifacts↗