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Biomedical subjects

T Ranta

Publications and source records attributed to T Ranta.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Improved diagnosis of pregnancy-associated gynaecological emergencies via rapid beta-HCG test (author's transl)].

A pregnancy-related disorder was identified by a rapid radioimmunoassay or serum chorionic gonadotropin in 151 out of 600 women (25%) with lower abdominal pain or bleeding, while a routine pregnancy test in urine was positive in only 7% of these cases. In 60 patients with ectopic pregnancy the rapid hCG-RIA was positive in 90% as compared with 10% for the routine pregnancy test. In patients with evidence of intrauterine pregnancy (80 cases) the rapid hCG-RIA was positive in 99% and routine pregnancy test in 39%. The clinical sensitivity of the hCG-RIA was 95%, specificity 96% and predictive value 88%. These figures should introduce a considerable improvement in the routine diagnosis of early intra- and extrauterine pregnancy-related disorders.

Chorionic Gonadotropin↗
PubMed1981

Improved diagnosis of pregnancy-related gynaecological emergencies by rapid human chorionic gonadotrophin beta-subunit assay.

A pregnancy-related disorder was identified by a rapid radioimmunoassay of serum chorionic gonadotrophin (hCG-RIA) in 122 out of 470 women (26 per cent) with lower abdominal pain or bleeding, while a routine pregnancy test in urine was positive in only 7 per cent of these cases. In 49 patients with ectopic pregnancy the rapid hCG-RIA was positive in 90 per cent as compared with 13 per cent for the routine pregnancy test. In patients with evidence of intrauterine pregnancy (66 cases) the rapid hCG-RIA was positive in 98 per cent and the routine pregnancy test in 38 per cent. The clinical sensitivity of the hCG-RIA was 95 per cent, specificity 96 per cent and predictive value 89 per cent. The test can improve the efficiency of the routine diagnosis of early intra- and extrauterine pregnancy-related disorders.

Chorionic Gonadotropin↗
PubMed1981

The effect of protamine on serum levels of placental protein 5 (PP5) in normal and abnormal pregnancy: a possible relation to coagulation abnormalities.

The levels of placental protein 5 (PP5) in pregnancy serum show an apparent increase after the addition of protamine sulphate. The difference of the apparent concentrations of serum PP5 in the presence and absence of protamine (delta PP5) was determined in 345 normal and abnormal pregnancies. A positive delta PP5 was less frequent in diabetic pregnancy (45 per cent) and pre-eclampsia (57 per cent) than in normal pregnancy (80 per cent). These findings provide further evidence that PP5 may be involved in the coagulation system, and in particular may relate to abnormal coagulation processes at the placental site.

Blood Coagulation↗
PubMed1981

Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease.

The circulating levels of chorionic gonadotropin, pregnancy specific beta-I-glycoprotein, prolactin and oestradiol were estimated by radioimmunoassay in 219 serum samples from 18 patients with choriocarcinoma and 45 samples from 8 patients with hydatidiform mole. Prolactin and oestradiol concentrations were higher in samples which also contained trophoblastic markers. This difference was also seen in patients with choriocarcinoma and it was not due to chemotherapy, since the difference between hCG positive and hCG negative samples was maintained during chemotherapy. Prolactin was found by immunoperoxidase technique in the syncytiotrophoblast of normal placenta throughout gestation, and also in hydatidiform mole, invasive mole and choriocarcinoma. It is suggested that the malignant syncytiotrophoblast may contribute to circulating prolactin levels either by direct secretion of prolactin or by oestrogen stimulation of the pituitary.

Chorionic Gonadotropin↗
PubMed1981

Human seminal plasma contains a protein that shares physicochemical and immunochemical properties with placental protein 5 from the human placenta.

Placental protein 5 (PP5)-like immunoreactive material was detected in human seminal plasma at high concentrations (32-1000 ng/ml). This was not due to interference with proteases or binding to seminal plasma proteins, since immunoreactivity was not affected by treatment with protease inhibitors, and incubation with seminal plasma of [125I]PP5 did not bring about any significant change in the elution pattern in gel filtration. Part of the PP5 immunoreactivity in seminal plasma had a molecular weight of 36,000-42,500 which is the molecular weight of purified PP5 from the human placenta. In RIa, serial dilutions of the 36,000-42,500 molecular weight material gave an inhibition curve parallel to that of the PP5 standard. The source of seminal plasma PP5-like material is not from the testes, as the levels in vasectomized men were similar to those in nonvasectomized men.

Chromatography, Gel↗
PubMed1981

Effect of short-term bromocriptine treatment on amniotic fluid prolactin concentration in the first half of pregnancy.

The effect of short-term bromocriptine treatment on amniotic fluid and maternal prolactin concentrations was studied in 9 pregnant women in the first half of pregnancy. Bromocriptine suppressed the maternal serum prolactin level, but had no effect on the amniotic fluid level. Since both foetal and maternal prolactin secretion are suppressed by bromocriptine our results suggest that amniotic fluid prolactin is produced by extrapituitary tissues, which do not contain dopamine receptors.

Amniotic Fluid↗
PubMed1981

Elevated prolactin levels in oral contraceptive pill-related hypertension.

Twenty women whose blood pressure became elevated during oral contraceptive treatment had higher serum prolactin levels (31 +/- 5.3 microgram/liter) than did 20 normotensive pill takers (16.1 +/- 1.8 microgram/liter) and 20 women who were not taking the pill (14 +/- 1.1 microgram/liter), and the higher level was maintained (30 +/- 3.5 microgram/liter) after the pill was discontinued and blood pressure had become normal. This increase in prolactin levels was not related to differences in age or mode of treatment, and it is thought to reflect an alteration in dopaminergic transmission in patients with pill-related hypertension.

Adult↗
PubMed1980

Use of a rapid hCG-beta-subunit radioimmunoassay in acute gynaecological emergencies.

Chorionic gonadotrophin (hCG) was measured by a rapid and sensitive radioimmunoassay in 100 female patients with lower abdominal pain attending an emergency department. Of the 24 subjects with a positive result, 22 had evidence of pregnancy (ectopic or uterine). Of the 76 patients with negative results, 3 had some evidence of pregnancy. This test may be of considerable practical value in the differential diagnosis of acute abdominal emergencies in women of reproductive age.

Abortion, Spontaneous↗
PubMed1980

Acute changes in serum prolactin concentration have no effect on the secretion of progesterone, estradiol, or chorionic gonadotropin during early pregnancy.

The relationship between the circulating levels of PRL and progesterone, estadiol, and hCG was studied during the first half of pregnancy. The subjects were 1) nine hyperprolactinemic women who conceived during bromocriptine treatment and whose treatment was discontinued at the 7th to 11th weeks of gestation; 2) five women given chlorpromazine during the 11th to 12th weeks of pregnancy; and 3) four pregnant women give bromocriptine during the 11th to 12th weeks of pregnancy. In group 1, discontinuation of bromocriptine resulted in elevated serum PRL concentrations, but this was not associated with any significant changes in the circulating levels of estradiol, progesterone, and hCG. In group 2, chlorpromazine increased the serum PRL concentration but had no effect on serum estradiol, progesterone, or hCG concentrations. In group 3, bromocriptine decreased the serum PRL level, but this was not associated with any alteration in steroid hormone or hCG levels. Our results show that during early pregnancy acute moderate changes in the serum PRL concentration do not affect placental hormone secretion.

Bromocriptine↗
PubMed1980

Maternal plasma prolactin levels in preeclampsia.

Maternal plasma prolactin, estradiol-17 beta, and free estriol levels were estimated in 118 normal pregnancies and in 90 patients with preeclampsia at 35 to 40 weeks' gestation. In the preeclamptic patients, the prolactin values were similar to those of normal pregnancy; the levels were not affected by the severity of disease. At 37 to 38 weeks' gestation the maternal plasma free estriol levels correlated positively with the prolactin levels in preeclampsia (r = .313; P less than .05; N = 64). No correlation was found between the levels of prolactin and estradiol-17 beta or between prolactin and urinary estrogen. Fetal distress was related to decreased plasma estradiol levels, but this was not reflected in the prolactin concentrations. The results of the present study show that the estimation of plasma prolactin level is of no clinical significance in patients with preeclampsia.

Estradiol↗
PubMed1979

Elevated plasma prolactin concentration in cholestasis of pregnancy.

The plasma concentrations of prolactin and estradiol-17 beta were measured by specific radioimmunoassays in 150 women with normal pregnancies and 76 women with cholestasis of pregnancy. At 33 to 34 weeks of gestation plasma prolactin concentrations were 187 +/- 23 ng/ml (mean +/- S.E.M.) for normal pregnancy and 341 +/- 38 ng/ml for cholestasis (p less than 0.001). At 35 to 36 weeks they were 254 +/- 24 and 355 +/- 26 ng/ml (p less than 0.01), and at 37 to 38 weeks 175 +/- 14 and 365 +/- 34 ng/ml (p less than 0.001), respectively. Higher prolactin levels in the cholestasis group were not related to differences in plasma estradiol-17 beta concentrations. No correlation was found between plasma prolactin and serum aminotransferase levels, or between prolactin levels and placental weight. The mechanisms by which plasma prolactin levels become elevated in cholestasis of pregnancy remain to be elucidated.

Cholestasis↗
PubMed1979

Bromocriptine treatment of spasmodic torticollis. A double-blind crossover study.

A double-blind crossover study (12 weeks and 12 weeks) was performed to evaluate the effects of bromocriptine on the symptoms and serum prolactin levels of 14 women with spasmodic torticollis. While the serum prolactin level decreased in response to bromocriptine, no difference was found between the effects of placebo and bromocriptine on the symptoms of spasmodic torticollis. Our findings suggest that dopaminergic neurotransmission is not involved in the pathogenesis of this syndrome.

Adult↗
PubMed1979

Bromocriptine treatment of oligospermia: a double blind study.

A double blind controlled study of bromocriptine treatment of oligospermia was carried out. Out of fifty-one men who originally volunteered to the study there were forty who took the drug for 12 weeks as requested. All the partners of these men had failed to conceive, and in each case the pretreatment sperm count had been below 40 million/ml on two or several occasions. The pretreatment serum prolactin concentrations were similar in patients given bromocriptine (N = 20) and placebo (N = 20). There were three men in either group whose pretreatment serum prolactin concentration was in excess of 30 micrograms/l, the highest value being 96 micrograms/l. While bromocriptine effectively decreased the serum prolactin concentration, it had no significant effect over placebo on sperm volume, motility and morphology. In the bromocriptine group, sperm count increased to or above 40 million/ml in five out of twenty men, while in the placebo group this occurred in nine out of twenty patients. The plasma testosterone and dihydrotestosterone levels increased slightly during treatment in both groups, but no significant difference was observed between bromocriptine and placebo treated patients. One wife of a bromocriptine-treated man and two wives of placebo-treated men became pregnant during treatment. In this study bromocriptine was no more effective than placebo in the treatment of oligospermia.

Adult↗
PubMed1979

Effects of acute hypotension and hypertension on serum TSH concentrations in male rats.

The effect of acute hypertension and hypotension on serum TSH concentration was studied in anesthetized male rats. I.v. infusions (10 and 30 min) of Na-nitroprusside and dihydralazine induced a profound hypotension, and angiotensin amide and noradrenaline increased blood pressure, but none of the treatments significantly modified serum TSH concentrations. Also clonidine and noradrenaline, when given i.p., caused hypertension, but again the increase of serum TSH levels was not consistent. When the whole material was analysed, there was a scarcely significant correlation between the change of blood pressure and the change of serum TSH level. It is inferred that the drugs affecting TSH secretion, do not exert their action solely by changing the blood pressure.

Acute Disease↗