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T Risberg

Publications and source records attributed to T Risberg.

25 records · Page 2Linked to original sources
PubMed1991

Trofosfamide in non-Hodgkin's lymphoma. A phase II study.

Twenty-three patients (12 females, 11 males) with malignant non-Hodgkin's lymphoma were treated with oral trofosfamide 50 mg t.i.d. Median age was 72 years. Fifteen patients had low-grade and 8 had high-grade lymphomas. Twenty-one patients had stage III and IV disease. Seven patients had WHO performance status of 3-4. The overall response rate was 61% (CR 22%, PR 39%) and the median duration of response 4 months (range 1.5-15+). The main side-effect was bone marrow depression and 7 patients experienced grade II or III hematological toxicity. No gastrointestinal or renal toxicity, no hair loss and no neurotoxicity were observed. The subjective tolerance was good.

Adolescent↗
PubMed1989

Establishment and evaluation of a radioimmunoassay for neuron-specific enolase. A marker for small cell lung cancer.

Neuron-specific enolase (NSE) was purified from human brain to a specific activity of 91 U/mg with no demonstrable impurities. The enzyme has a molecular weight of 96,000, consists of two subunits of 47,000, and has an isoelectric point at pH 4.5. A radioimmunoassay based on antibody raised in sheep was established. The assay has a sensitivity of 2 micrograms/l, and an interassay coefficient of variation of 6.4% at 10 micrograms/l. The reference limit was defined as 10 micrograms/l, as found in sera from a population of 389 persons. Of 50 untreated patients with small cell lung cancer (SCLC), 70% had NSE levels above 10 micrograms/l. None of 170 patients with non-SCLC neoplasms had elevated enzyme levels.

Adult↗
PubMed1987

The diagnostic value of human chorionic gonadotrophin in patients with testicular seminoma.

Human chorionic gonadotrophin (HCG) was measured in sera from seminoma patients by an immunoassay which recognised both free beta-chains and intact HCG molecules. This seemed to increase the sensitivity of the assay without affecting its specificity. The HCG values were correlated to the clinical course in 151 patients. Pre-orchiectomy samples were assayed in 57 patients. Elevated pre-operative HCG levels were found in 15 of 38 patients (39%) in stage I and in 13 of 19 patients (68%) in stages II to IV. After orchiectomy the HCG values were normal in 114 of 115 patients in stage I and elevated in 13 of 36 patients (36%) in stages II to IV. Relapses were observed more often in stage II to IV patients who produced HCG at the time of diagnosis than in non-producers (3 of 13 patients versus 1 of 23 patients). In 7 of 11 relapses the serum HCG was elevated. HCG positive relapses were seen in patients both with and without initially elevated serum HCG.

Adult↗
PubMedDate not supplied

Opinions on and use of alternative medicine among physicians, nurses and clerks in northern Norway.

In February 1997 a questionnaire on alternative medicine was distributed to 172 physicians, 374 nurses and 96 clerks, all employed in hospitals in the northern part of Norway. A response rate of 57% was achieved. The aim of the study was to compare different health professions regarding views on and use of alternative medicine. Among all respondents 56% described themselves as having a positive attitude towards alternative medicine (16% of the physicians, 71% of the nurses and 72% of the clerks). Twelve percent of physicians, 32% of nurses and 46% of clerks had been using alternative medicine. Female physicians and female nurses showed a more positive attitude and were more frequent users of alternative medicine than their male counterparts. Physicians had confidence in acupuncture, herbs and diets, mainly as treatment of muscle-skeletal disorders, and migraine. Nurses and clerks on the other hand tended to believe in various alternative methods against a broad range of disorders. Female physicians and nurses emphasised the importance of more information, knowledge and openness towards alternative treatments more than their male counterparts. They also believed that traditional medicine could benefit from adopting principles from alternative medicine.

Administrative Personnel↗
PubMedDate not supplied

Diagnostic delay causes more psychological distress in female than in male cancer patients.

From July 1990 to July 1991, 263 consecutive cancer patients admitted to our oncological unit for the first time were invited to participate in a questionnaire based study. 252 patients responded and were included in the final analysis. The aim of the survey was to examine the delays involved in diagnosis and treatment of cancer and the possible psychological distress associated to the different periods of delay. A shorter patient delay was found among patients under the age of 30 years (P < 0.005). Patients with higher education had a significantly shorter delay from the time of contact with the GP to admittance to the local hospital (P <0.005). The diagnostic delay was reported to be significantly more distressing for females compared to males (P <0.05). The reported psychological distress, however, correlated positively to the actual length of total delay (P<0.005) for both sexes. All patients reported that the delay between local hospital referral and admittance to the oncological unit to be the most distressing delay period to cope with.

Adolescent↗
PubMedDate not supplied

Patients' opinion and use of non-proven therapies related to their view on cancer aetiology.

BACKGROUND: The aim of the study was to investigate patients' attitudes to and use of nonproven therapies (NPTs) in view of their opinions about causes of cancer. MATERIAL AND METHODS: A comparative questionnaire-based study was given to patients with non-malignant disease (n = 305) seen in general practice and cancer patients (n = 252) seen at the Department of Oncology, University Hospital of Tromsø. RESULTS: Among non-cancer patients significantly more NPT-positive than NPT-negative patients considered the environment to be an important cancer cause (74% versus 52%) and that food and drink may be carcinogenic (57% versus 40%). For cancer patients, there was no such difference. 60% of non-cancer patients and 35% of cancer patients believed that life style changes could alter the natural course of cancer. In both groups of patients, the NPT-positive believed, to a higher degree than the NPT-negative, that the outcome of cancer could be improved by a change in life style (69% and 48% versus 53% and 29%). CONCLUSION: Patients positive to NPTs have firmer beliefs with respect to the importance of environmental factors than non-believers/-users. Moreover, these patients believed more strongly than NPT-negative patients that change of lifestyle may influence the outcome of cancer positively.

Adolescent↗