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T Rokkas

Publications and source records attributed to T Rokkas.

44 records · Page 3Linked to original sources
PubMed1987

Campylobacter pylori and non-ulcer dyspepsia.

Non-ulcer dyspepsia (NUD) is a poorly understood syndrome often present in association with gastritis. Among patients undergoing gastroscopy, some with NUD have a gastric mucosa colonized by the campylobacter-like organism, Campylobacter pylori. We therefore studied prospectively 55 consecutive patients with NUD and 15 normal controls to determine the prevalence of C. pylori organisms, and to investigate their association with histological gastritis, macroscopic evidence of gastritis, sex, smoking, alcohol consumption, and dyspeptic symptoms. We found a 45.4% prevalence in NUD patients which was statistically significantly higher than the 13.33% prevalence in the control group (p less than 0.05). We also found a close association between C. pylori and microscopic evidence of gastritis (p less than 0.001), male sex (p less than 0.001), and postprandial bloating (p less than 0.05). We did not find any significant association between C. pylori and macroscopic evidence of gastritis, smoking, alcohol consumption and other dyspeptic symptoms. Our findings suggest that C. pylori may play a pathogenic role in NUD.

Adolescent↗
PubMed1986

The role of shorter than 24-h pH monitoring periods in the diagnosis of gastro-oesophageal reflux.

We studied 20 patients with typical symptoms of gastro-oesophageal reflux, to determine whether the diagnostic accuracy of 24-h pH monitoring might be retained in a test using a shorter time. The duration and number of reflux episodes were used to calculate a frequency and duration score (FDS) for the 24-h period, the daytime period, the nighttime period, a 3-h postprandial period after eating a test meal (provocation test), and a 21-h period that excluded this 3-h postprandial period. The daytime FDS was significantly higher than nighttime FDS (p less than 0.02), and there was good correlation between the 21-h FDS and the 3-h postprandial FDS (rs = 0.695; p less than 0.01). We conclude that the 3-h postprandial testing after a standard meal provocation test is a practical, accurate, and well-tolerated method of diagnosing gastro-oesophageal reflux. The results also demonstrated the relative importance of daytime as opposed to nocturnal reflux in producing symptoms and oesophagitis.

Adult↗
PubMedDate not supplied

Optimal dose of omeprazole in combination with amoxicillin in eradicating H. pylori and preventing relapses in duodenal ulcer patients.

BACKGROUND/AIMS: Triple therapy schemes, based on bismuth salts, eradicate H.pylori in a high percentage of duodenal ulcer (DU) patients. However, a simple and effective regime with a low complication rate is desirable. Previous studies have shown that the combination of Omeprazole (O) with an antibiotic (most commonly Amoxycillin [A]) is effective, but the optimal dose of O in this combination is not well defined. The aim of this study therefore was to address this subject. MATERIALS AND METHODS: The following four groups of patients were studied: group I (20mg O daily + 500mg A qid, n=18), group II (20mg O bid + 500mg A qid, n=17), group III (20mg O tid + 500mg A qid, n=18), group IV (20mg O qid + 500mg A qid, n=20). Patients were treated for two weeks with the above combinations. Endoscopy was performed four weeks after stopping treatment to check for H. pylori eradication and then one year later or when symptoms suggesting relapse occurred. RESULTS: Eradication rates were as follows; group I 6/18 (33.3%), group II 10/17 (58.8%), group III 15/18 (83.3%), group IV 17/20 (85%). The highest eradication rate was achieved in group IV which was significantly higher (P<0.001) than in all the other groups except for group III. After treatment, there was a total of 48 H. pylori (-) and 25 H. pylori (+) patients in the four groups of patients studied. Relapse occurred in 20/25 (80%) of the H. pylori (+) patients and in only 2/48 (4.16%) of the H. pylori (-) patients (P<0.001). CONCLUSIONS: a) The combination of Omeprazole and Amoxycillin is effective in eradicating H. pylori. It seems that in this combination 60 or 80mg of Omeprazole is equally effective in achieving high percentages of eradication. Eradication of H. pylori with this regime prevents duodenal ulcer recurrence.

Adult↗