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T Rooke

Publications and source records attributed to T Rooke.

5 recordsLinked to original sources
PubMed2001

Time to think small.

Explore the source record for details and available documents.

Education, Medical, Continuing↗
PubMed1998

Factors affecting clinical outcome following endoscopic perforator vein ablation.

BACKGROUND: Despite good outcomes reported with minimally invasive, subfascial endoscopic perforator surgery (SEPS), some patients demonstrate poor healing or recurrence of venous ulcers. The goal of this study was to identify factors that lead to failure of SEPS. METHODS: Forty-eight consecutive patients who had undergone 57 SEPS procedures were analyzed. Mean follow-up was 17 +/- 2 months (range 2 weeks to 52 months). RESULTS: All active ulcers (n = 22) at the time of surgery healed in an average of 99 +/- 37 days (range 11 to 670). Eight limbs had poor healing of their ulcer (>40 days); five (9%) new/recurrent ulcers developed postoperatively. Deep venous obstruction was associated with delayed ulcer healing (316 +/- 171 versus 51 +/- 14 days, P < 0.01) and ulcer recurrence (P < 0.0001). Poor ulcer healing and recurrence were not associated with lipodermatosclerosis, edema, ulcer duration >3 months, or previous recurrences. Ulcer size >2 cm (P < 0.05) and combined ilio-femoral and popliteal/tibial reflux were associated with poor ulcer healing (P < 0.05). CONCLUSIONS: SEPS could not prevent recurrent or new ulceration in 9% of limbs. Venous outflow obstruction was associated with ulcer recurrence and prolonged ulcer healing. Multilevel deep venous reflux and ulcer size >2 cm were also associated with delayed healing.

Adult↗
PubMed1982

Non-neurogenic inhibitory effect of electrical impulses in isolated canine coronary arteries.

Electrical stimulation caused frequency-dependent reversible relaxations of canine coronary arteries made to contract with prostaglandin F2 alpha, phenylephrine, 5-hydroxytryptamine, potassium chloride, or angiotensin II. These contractions were not affected by cold storage, tetrodotoxin, alpha- and beta-adrenergic blockade and atropine, demonstrating that they probably are not due to activation of inhibitory nerves. The relaxations persisted in the presence of indomethacin and after removal of the endothelium. They were not seen in splenic arteries and saphenous veins, demonstrating the high sensitivity of the coronary blood vessel wall to the inhibitory effects of the electric impulses.

Animals↗