The value of needle renal allograft biopsy.
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Biomedical subjects
Publications and source records attributed to T Rott.
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Rhabdomyoma is an extremely rare benign tumor originating from the skeletal or cardiac muscle cells. Only 87 cases of rhabdomyoma have been reported to date, 70% occurring in the head and neck areas. The authors present the fourth case of rhabdomyoma of the nasopharynx. The tumor appeared in an 18 year old woman with hypacusis. Examination of the epipharynx showed a 2 x 1,5 cm tumor, extending from torus tubarius down to the soft palate. Light microscopy disclosed areas and islands of polymorphous large cells with abundant eosinophilic cytoplasm. Cross striations were focally visible with special PTAH staining. Electron microscopy revealed parallel and haphazardly arranged fibrillar bands (myofibrils) with irregularly and periodically arranged densities corresponding to Z lines. The pecularities of our case were abundant cystically dilated rough endoplasmatic reticulum and the absence of cytoplasmatic glycogen.
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Many investigations stress the importance of dysplastic changes of bronchial epithelium, chronic bronchitis, and chronic scar producing inflammatory processes of the lung in the development of bronchopulmonary carcinoma.--At the Institute for Lung Diseases and Tuberculosis Golnik in the period from 1964--1973 we found among 185 surgically resected lungs 20 cases (10,8%) of pulmonary scar cancer. In six patients (30,0%) we proved the tuberculous origin of the scar. Scar cancer was established in 18 patients (90,0%) in the upper parts of the lung. In half of all cases adenocarcinoma was found, squamous cell carcinoma was present in two cases and small cell anaplastic carcinoma in one case. --In the same period we found in surgically resected material two cases of tumourlets. In the first case in a 49-year old woman, the tumourlet was located in the scar surrounding an aspergillus mycetoma in the right upper pulmonary lobe. In the second case a tumourlet was found in a 42-year old woman in the region of focal fibrosis of the right upper pulmonary lobe. An 8 respectively 12 years postoperative follow-up shows no recurrence in both patients. This corresponds to the data from literature describing the tumourlet as benign process, recently reported as a minute peripheral carcinoid tumour.
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Knowledge about the normal structure and pathology of interstitial capillary is limited. Splitting and multilayering of the basal membrane (BM), as a marker of chronic rejection, has been published in association with transplant glomerulopathy. The authors investigated the ultrastructural features of the interstitial capillary basal membrane in normal (15 biopsies) and in transplanted kidneys (27 biopsies from 21 patients), expressing transplant glomerulopathy (8 biopsies from 6 patients), acute tubulo-interstitial rejection (9 biopsies from 6 patients), and recurrent or de novo glomerulonephritis (10 biopsies from 8 patients). All biopsies were fixed in 1% OsO4, embedded in Epon, and examined by electron microscope. Measurements of the interstitial capillary BM were made. The BM of interstitial capillary of intact kidney was a homogenous continuous structure, 88 nm in width on average. Thickening with diffuse multilayering of BM was most intensive in patients with transplant glomerulopathy, and much less intensive in patients with acute tubulointerstitial rejection and in patients with recurrent or de novo glomerulonephritis. These findings may provide the first information about the morphology of the normal basal lamina of interstitial capillary and support the diagnostic value of interstitial capillary changes in chronic rejection.
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