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T Roumeguère

Publications and source records attributed to T Roumeguère.

5 recordsLinked to original sources
PubMed2006

[Screening for prostate cancer: role of PSA in 2006].

PSA is the best tool for prostate cancer diagnosis. The wide use of PSA with time leads to localized tumour detection with better prognostic factors. The role of PSA for screening is debatable with a doubt on the traditional cut-off of 4 ng/ml. Lowering PSA levels leads to a higher detection rate but also increases the risk of overdiagnosis. Potentially aggressive tumours can not be identified by appropriate PSA cut-off level. Even with low value of PSA < 3 ng/ml, aggressive cancers are diagnosed. The goal is to identify aggressive but still curable diseases with an acceptable accuracy. News strategies for early diagnose are reviewed with the interest of PSA for screening in 2006.

Biomarkers, Tumor↗
PubMed2004

[Relationship between erectile dysfunction and cardiovascular disease].

The incidence and severity of erectile dysfunction increase with age and factors of comorbidity. Erectile dysfunction is predominantly of vascular origin and shares common risk factors with cardiovascular disease. An association between erectile dysfunction and ischemic heart disease has been suggested due to the impairment of the endothelium-dependent relaxation of smooth muscle. There is accumulating evidence suggesting that erectile dysfunction could be a sentinel event for cardiovascular disease and not only for quality of life evaluation. Atherosclerosis lesions are variable in localisation with time. Erectile dysfunction could represent a marker of infraclinic vascular disease and a predictor of the progression of cardiovascular disease. This is of importance to conduct appropriate approach of cardiac risk towards patients with erectile dysfunction to decrease morbidity of cardiovascular disease.

Cardiovascular Diseases↗
PubMed2003

[Erectile dysfunction and phosphodiesterase type 5 inhibitors].

Erectile dysfunction affects 150 millions of men and its prevalence increases with age. The improvement of life expectancy will increase the worldwide prevalence to 300 million in 2025. Oral treatments are nowadays the first line therapy for the vast majority of people as they have a good reliability and tolerance and restore more spontaneity. The authors relate the widespread interest in phosphodiesterase type 5 inhibitors with the advent of sildenafil for the treatment of erectile dysfunction and present characteristics of 2 new phosphodiesterase type 5 inhibitors in Belgium, tadalafil and vardenafil.

3',5'-Cyclic-GMP Phosphodiesterases↗
PubMed2000

Is one set of sextant biopsies enough to rule out prostate Cancer? Influence of transition and total prostate volumes on prostate cancer yield.

PURPOSE: Although the sextant biopsy technique has been widely used, concern has arisen that this method may not include an adequate sampling of the prostate, especially for large prostate volumes. We conducted a multicenter study in patients with PSA levels <10 ng/ml to determine the influence of the total and transition zone (TZ) volumes of the prostate for predicting whether one single set of biopsies was sufficient to rule out prostate cancer (PCa). These parameters were evaluated in patients in whom PCa was found after one set of systematic sextant biopsies and those in whom PCa was found after a repeat biopsy. MATERIALS AND METHODS: A total of 1,018 patients were included in this study. All underwent transrectal ultrasound-guided needle sextant and two TZ biopsies of the prostate. Total and TZ volumes of the prostate were measured (prolate ellipsoid method). From this cohort, all patients in whom a benign disease was found after the first set of biopsies underwent a second similar set of biopsies within 6 weeks. Only patients with PCa were included in this study, whether diagnosed on first or repeat biopsy. Uni- and multivariate statistical analysis using the SAS system (Cary, N.C., USA) and ROC curves were used to compare patients in whom the diagnosis was performed after the first set of biopsies and those who required a second set. RESULTS: Of the 1,018 patients, 344 (33.8%) had PCa diagnosed, 285 (28%) after the first set of biopsies, and 59 (8.1%) on repeat biopsy. As compared to patients diagnosed with PCa after the first set of biopsies, patients diagnosed after the second set had larger total prostate and TZ volumes (43.1+/-13.0 vs. 32.5+/-10.6 cm(3), p<0.0001 and 20.5+/-8.3 vs. 12.8+/-6.0 cm(3), p<0.0001). ROC curves showed that total and TZ volumes of 45 and 22. 5 cm(3), respectively, provided the best combination of sensitivity and specificity for discriminating between patients diagnosed with PCa after the first from those diagnosed after a second set. CONCLUSION: In patients with total prostate volume >45 cm(3) and TZ >22.5 cm(3), a single set of sextant biopsies may not be sufficient to rule out PCa. In these patients, a repeat biopsy should be considered in case of a negative first biopsy.

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