Biomedical subjects
Publications and source records attributed to T S Briuzgina.
Seasonal variations (with a peak in winter and a fall in summer) in the level of arachidonic acid in low-density lipids, in heart rate, and blood pressures were studied in patients with angina pectoris. The findings are required for a better understanding the mechanism and for development of preventive measures against ischemic heart disease.
The results of gas-chromatography assay of the fatty-acid composition of lipids of low-density lipoproteins contained in blood serum of patients after myocardium infarction are described in the paper. The obtained data can be used in clinical practice for substantiating a therapeutic approach with the aim of enhancing the treatment efficiency.
Gas-chromatographic analysis of fatty acid composition of sweat lipids in children and adults with neurodermatitis, atopic dermatitis, and eczema showed that sweat can be used as a new noninvasive biological object for evaluation of lipid metabolism disorders.
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The results of gas chromatographic analysis of fatty acid composition of cell cultures infected with Coxsackie B viruses (CBV) and of sera of patients with unstable angina, psoriasis, and after stroke indicate that the presence of CBV in the organism can be one of the causes of lipid dysmetabolism.
Fatty acid composition of plasma lipids, erythrocytes, and the lens has been determined in patients with senile cataracts. The results indicate that coronary disease is a risk factor fraught with disorders in lenticular lipid metabolism.
In experiment on muscle flaps of 20 rabbits the peculiarities of their tissues damage in the ischemia period, and also due to the oxygen-dependent processes activation (peroxidal and free radical oxidation of a membrane phospholipids) in period of its reperfusion were studied. Preliminary introduction of a lipin, unitiol and ascorbic acid mixture in the flap arterial channel had promoted the reduction of damage severity in the translocated flap cells biomembranes due to ischemia and reperfusion, causing inhibition of the lipids peroxidal oxidation processes, rising of the flap tissues antioxidant defense, the cell and subcell membranes stabilization which preserves the vessels endothelium integrity. This showed a promising future for application of these preparations in a free transplantation of compound tissue complexes.
Fatty-acid composition was determined of blood lipids, the expired air condensate, sweat, and lung tissue in uncomplicated myocardial infarction and development of acute left ventricular insufficiency and ventricular fibrillation. While comparing the results obtained it was found out that the most manifest changes in the fatty-acid composition of lipids occur in erythrocytes, the expired air condensate, and sweat in complicated course of myocardial infarction. Unlike blood serum, the expired air condensate, and sweat, erythrocytes reveal heterodirectional changes in the content of saturated and unsaturated acids. The same tendency has been noted in lung tissue in ventricular fibrillation.
Results are submitted of a gas-chromatographic analysis of FA in the blood and eliminate from the eyes of patients with AC. Similarity was found out of changes in the content of PNFA in these biological objects. It is therefore justifiable to use electroeliminate, a new noninvasive biological object, in a clinical setting to assess abnormalities of lipid metabolism in the eye in AC.
Fatty-acid composition of lipids was studied by gas chromatography techniques as was the level of free cholesterol in high- and low-density lipoproteins in 15 patients with chronic hepatitis and 15 hepatocirrhotic patients. Significant changes in fatty-acid spectrum were recordable suggesting activation of the process of lipid peroxidation. The above changes were at their greatest in patients with hepatocirrhosis.
Higher fatty acids of low- and high-density lipoprotein lipids are analyzed by gas chromatography in patients with chronic diseases of the liver (chronic cholecystitis, cholelithiasis, chronic hepatitis, and cirrhosis of the liver). The results recommend the fatty acid composition of serum lipoprotein lipids as an informative characteristic in evaluation of lipid metabolism disorders in the liver.
Fatty-acid composition of lipids was determined as was activity of lipid peroxidation and lung tissue content of neutral fats and phospholipids in myocardial infarction during the acute phase of the course of the disease using gas-chromatographic, biochemical, and morphological techniques. Lung tissue in myocardial infarction was found out to accumulate neutral fats. Also recordable in lung tissue was redistribution of phospholipids, with the interalveolar septa structures getting reduced, which fact is accompanied by changes in fatty acid composition of lipids together with activation of lipid peroxidation processes.
Lipids of exhaled air condensate (EAC) and sweat are analyzed by gas chromatography in coronary patients with myocardial infarction complicated by lung edema. Changes of lipid fatty acid spectrum in EAC and sweat were uniform: the levels of linoleic and arachidonic acids were increased, which can aggravate the disease and lead to complications.
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Gas chromatographic analysis of the lipid fatty acid spectrum of blood (serum and plasma), sweat, and exhaled air condensate in children with acute pneumonia and dermatitis caused by alimentary allergies showed good correlation of the results. Therefore, biological objects obtained by noninvasive methods can be used for studies of lipid metabolism in children.
Sweat lipids fatty acid (FA) composition was determined in patients presenting with uncomplicated course of acute myocardial infarction and in the development of pulmonary edema and pneumonia with the aid of a gas-chromatographic technique. The development in the patients of pulmonary complications was found out to be accompanied by a substantial elevation of sweat lipids content of polyunsaturated FA, linoleic and arachidonic FA in particular, which fact can be taken as a diagnostic and prognostic criterion.
The lipid fatty-acid spectrum in exhaled air condensate (EAC) was analyzed in children with bronchopulmonary diseases by gas chromatography. The detected shifts in the fatty-acid composition of EAC lipids may be used for validating a therapeutic approach and monitoring the treatment efficacy.