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Biomedical subjects

T S Brown

Publications and source records attributed to T S Brown.

At least 19 recordsLinked to original sources
PubMed1994

Leukocytosis in labor: what are its implications?

OBJECTIVE: The objective of this study was to determine the usefulness of the peripheral white blood count (WBC) drawn during labor as a predictor of postpartum morbidity. METHOD: Hospital charts on 309 consecutive obstetrical deliveries performed by residents of the Cox Family Practice Residency were reviewed for evidence of maternal or neonatal postpartum morbidity. An analysis of means was used to compare the average antepartum WBC in the morbid and non-morbid groups. RESULTS: The average WBC in a laboring patient was 12,450, with a range of 4,400 to 29,100. Patients with postpartum complications had a WBC similar to that of patients without complications (12,900 vs 12,300 p = 0.449). CONCLUSION: An elevated WBC obtained on admission to the labor ward is not helpful in predicting postpartum complications in mothers or newborns.

Adolescent↗
PubMed1993

Breast imaging in women under 35 with symptomatic breast disease.

With the increasing utilization of mammography, young women under the age of 35 are being referred for mammographic examination more frequently. A review of the mammograms of 159 consecutive patients aged under 35 was conducted to evaluate the clinical value of the examination in the age group for whom the probability of malignancy is low. 74% of patients referred had no discrete palpable mass and presented predominantly with lumpy or tender breasts, the remaining 24% had a discrete palpable mass. In neither group did radiographic examination beneficially influence clinical management. We propose protocol where no imaging is performed in women under 35 in the absence of a palpable mass unless there is a localized bloody discharge or a strong family history or previous personal history of breast cancer. In patients with a palpable mass, ultrasound should be performed initially to identify simple cysts and if negative only then progressing to mammography.

Adult↗
PubMed1992

Aluminum accumulation in serum, liver and spleen of Fe-depleted and Fe-adequate rats.

The study described here was planned to test the hypothesis that Al absorption and accumulation in the body are inversely related to Fe status. Aluminum3+ and Fe3+ have similar ionic radii and charge densities, pH-solubility relationships, and affinities for ligands, such as citrate and transferrin. Male weanling Sprague-Dawley rats were pair fed an Fe-deficient or Fe-adequate (control) diet for 2 wk. Each diet group was then randomly assigned to receive for four more weeks the Fe-deficient or adequate diet with: 1. 2% AlCl3; 2. AlCl3 + 3.5% Na citrate; or 3. No Al or citrate. Iron depletion, confirmed by measurements of hemoglobin, hematocrit, serum Fe, and Fe binding capacity, increased concentrations of serum, liver, and spleen Al in all groups fed AlCl3. However, the increase owing to Fe deficiency was significant only when Al was fed with citrate. The data suggest that Fe deficiency enhances both Al absorption and accumulation in liver and spleen.

Administration, Oral↗
PubMed1987

Tuberculosis affecting the oesophagus.

Three Asian patients presenting with dysphagia were shown to have oesophageal involvement secondary to adjacent tuberculous mediastinal lymph nodes. The findings included fistula between the oesophagus and the tracheobronchial tree and extrinsic compression of the oesophagus. These cases reflect the increasing incidence of mediastinal lymphadenopathy in adult tuberculosis, especially in our immigrant community.

Adult↗
PubMed1987

Double-blind, placebo-controlled trial of twice-daily nifedipine as a step-2 agent in mild essential hypertension.

Nifedipine is a calcium-channel blocker that produces vasodilatation and decreased peripheral resistance in humans. Several clinical reports document blood-pressure-lowering effects of nifedipine with either acute or chronic administration. Little data are available to evaluate sustained-release nifedipine as a step-2 agent. We performed a multicenter double-blind, placebo-controlled trial of twice-daily nifedipine in the treatment of mild essential hypertension not controlled by diuretic alone. Seventy-one subjects completed 8 weeks of treatment with nifedipine or placebo in combination with a stable dose of diuretic. Treatment groups were comparable with respect to age, sex, race, duration of hypertension, and pretreatment weight. Baseline supine blood pressure was no different in the two treatment groups (144 +/- 15/98 +/- 6 mmHg in the nifedipine/diuretic-treated group and 145 +/- 16/98 +/- 6 mmHg in the placebo/diuretic-treated group). After 8 weeks of treatment, supine blood pressure was 132 +/- 11/88 +/- 6 mmHg in the nifedipine/diuretic-treated group and 140 +/- 16/92 +/- 8 mmHg in the placebo/diuretic-treated subjects (p less than 0.01 for both systolic and diastolic blood pressure when compared to placebo/diuretic). Nifedipine with diuretic had similar effects on standing blood pressure. Nifedipine/diuretic decreased blood pressure from baseline values within 1 week of treatment, and the effect persisted for 8 weeks. Heart rate increased in nifedipine/diuretic-treated subjects during the first 2 weeks of treatment but returned to baseline by 4 weeks. No laboratory abnormalities could be attributed to nifedipine/diuretic treatment. Side effects were mild and infrequent. In summary, nifedipine/diuretic is effective and well tolerated in the treatment of uncomplicated essential hypertension inadequately controlled with diuretic therapy alone.

Adult↗
PubMed1980

Tuberculosis of the ribs.

The radiological appearances of seven cases of rib tuberculosis are discussed. The combination of rib destruction and an extrapleural soft tissue opacity in an Asian immigrant makes tuberculosis a highly likely diagnosis. The presence of an associated fluctuant chest wall swelling, enables a diagnosis of tuberculosis to be made with confidence even in Caucasians.

Adolescent↗
PubMed1980

Tuberculous mediastinal lymphadenopathy in Bradford.

During the calendar year 1978, 18 patients who commenced treatment for pulmonary tuberculosis in the Bradford Chest Clinic were found to have enlarged mediastinal lymph glands. Sixteen of these 18 patients were adults who thus presented radiographic patterns which have been classically regarded are representing primary tuberculous infection and are usually seen in children but only rarely in adults. All 16 adult patients were immigrants of either Indian or Pakistani origin. Tuberculosis is therefore a common cause of mediastinal lymphadenopathy in the immigrant population and in view of the successful response to therapy it should be considered ahead of the more usual diagnoses of lymphoma, sarcoidosis or metastatic carcinoma.

Adult↗
PubMed1980

Tuberculosis of the skull vault.

Tuberculosis of the skull vault is very rare and recently has only been reported from Africa. Two cases have presented in the city of Bradford during the past 10 years, both in young Asians. The radiology is discussed.

Adolescent↗
PubMed1979

Plasma corticosterone levels and ulcer formation in rats with hippocampal lesions.

In order to examine the effects of hippocampal lesions on plasma corticosterone levels and ulcer formation, 4 conditions were studied: (1) unrestrained nondeprived (2) unrestrained 24 h food-deprived (3) simple restraint and (4) restraint plus intermittent shock. In the unrestrained and unrestrained plus 24 h food-deprived conditions, neither animals with hippocampal lesions nor control animals developed ulcers. In both instances plasma corticosterone levels were similar in experimental and control animals. Differences appeared in the simple restraint and restraint plus intermittent shock conditions. In both of these conditions animals with hippocampal lesions developed more ulcers and had a higher corticosterone level than controls. It is concluded that animals with hippocampal lesions show an enhanced reaction to stress.

Animals↗
PubMed1976

Chronic intermittent ethyl alcohol inhalation and avoidance learning.

Weanling male and female rats were chronically exposed to alcohol for 50 days using an intermittent inhalation technique which does not cause alcohol dependency. After 17 days of no exposure to alcohol, animals began two-way active avoidance testing. Results indicated that males were impaired on this task and females were not while at the same time males had reduced body weights. The male weight reduction was not responsible for the avoidance impairment. It was concluded that impaired avoidance learning following chronic esposure to alcohol is not specific to dependency models of animal alcoholism.

Aerosols↗
PubMed1975

Effects of desalivation on schedule-induced polydipsia in the rat.

The development and magnitude of schedule-induced polydipisa (SIP) were examined in desalivate and control rats in two experiments. In Experiment 1 animals were placed on a noncontingent fixed time (FT) 60-sec schedule for 24 days. Results indicate speeded development but asymptotically lower levels of SIP in desalivate rats compared to controls. Home cage consumption, however, was elevated in desalivate rats. In Experiment 2 schedule length, pellet size, and the percentage of body weight were manipulated. Desalivate rats consumed less fluid during each schedule condition relative to controls, but the pattern of results across schedules was similar to controls. It was concluded that (a) desalivation attenuates SIP; (b) SIP is a learned phenomenon; (c) dry mouth theories of SIP appear inadequate; and (d) the developmental aspect of the SIP phenomenon deserves additional research attention.

Animals↗