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PubMed1988

Coronary artery reoperations. Early and late results in 101 patients.

Coronary artery reoperation was performed on 101 patients between 1972 and 1985. The resternotomy was associated with major hemorrhage in 12 cases. Of 29 patent internal mammary artery (IMA) grafts, 11 (38%) were damaged during mobilization of the left ventricle. At reoperations performed more than a year after the initial operation, increased graft blood flow compared with the first operation was observed in IMA but not in vein grafts. There were six early deaths (6%). The 5-year survival rate, inclusive of early mortality, was 90%. After a median of 2.5 years, 82% of the patients reported symptomatic improvement and 22% were completely free from angina, but full physical fitness was restored in only 3%. Excluding the patients of retirement age, 35% were able to resume work after the reoperation. Coronary artery reoperation should be considered only for patients with severe angina, because of the increased surgical risk and the lower likelihood of completely relieved symptoms. Presence of a patent IMA graft necessitates special caution.

Angina Pectoris↗

PubMed1984

Prosthetic valve endocarditis.

Fifty-three (3.6%; actuarially 4.1% at 48 months) of 1465 consecutive in-hospital survivors of valve replacement from 1975 to July 1979 (aortic, mitral, or aortic and mitral, only one untraced) developed prosthetic valve endocarditis (PVE). Incremental risk factors for developing PVE were native valve endocarditis (p less than .0001), black race (p = .0001), mechanical prosthesis (vs bioprosthesis) (p = .005), male sex (p = .04), and longer cardiopulmonary bypass time (p = .09). In general, the hazard function for developing PVE was greatest at 3 weeks after valve replacement. Patients with native valve endocarditis had a tendency to develop PVE early after valve replacement, as did patients in whom mechanical prostheses were used. PVE associated with Staphylococcus epidermidis tended to appear within 6 months of valve replacement, whereas streptococcal PVE tended to appear later after valve replacement. PVE took an atypical form in some patients, but patients with possible PVE (n = 6) had the same findings as those with certain PVE (n = 47). In 11 patients bacteriologic confirmation of PVE was not obtained. The typical prosthetic and periprosthetic characteristics of PVE were present in 30 of the 40 cases in which observations were possible. PVE is a serious condition; 34 (64%) of our 53 patients died. Most deaths occurred within 3 months of the first evidence of PVE. Recovery of some patients is possible with appropriate medical and surgical treatment, but more intense preventive measures are indicated.

Endocarditis, Bacterial↗