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T S Kamynina

Publications and source records attributed to T S Kamynina.

17 recordsLinked to original sources
PubMed1994

[The role of mutagenic factors in the development of diffuse toxic goiter].

The role of mutagenic factors in the onset of diffuse toxic goiter (DTG) was studied in 49 families of probands with DTG. The evidence obtained on the order in which the child was born in the proband's family, age of the parents at the time of DTG child delivery, implications of occupational factors in DTG onset does not rule out mutagenic effects in the origin of DTG and thus feasibility of the key gene influence on the disease predisposition.

Adolescent↗
PubMed1994

[HLA haplotypes and the predisposition to diffuse toxic goiter].

The results of the family immunogenetic study compared to HLA-typing on the population-genetic level have established a population positive association which was more strong with HLA system regions B and DR (antigens B17, B35, DR5). Haplotype HLA A3, B35, DR5 may be considered as the haplotype of predisposition to diffuse toxic goiter. The strength of the association DT3 with antigens A3, B35, DR5 in the family study was superior to that in the population one. A new association of antigen HLA B44 with family variant of the goiter was revealed as was the fact that the proband's parents carry the predisposition haplotype, the segregation being from the parents to sibs and the proband's children. Registration in the children of the proband of the predisposition haplotype or separate antigens (B17, B35, B44, DR5) suggests the risk of diffuse toxic goiter in the proband's children.

Adolescent↗
PubMed1993

[HLA class I and II antigens and diffuse toxic goiter].

The incidence rate of HLA class I and II antigens has been studied in 168 and 82 patients with diffuse toxic goiter, respectively. Positive association is found for HLA antigens A2, A3, A28, B8, B15, B17, Cw4, DR5; negative one with antigens A24, Bw4, Bw6, Cw1, Cw2, Cw3, Cw5, DR9. Prevalence of antigens B15, B17, Cw4, DR5 is associated with thyrotoxicosis severity, A2 with recurrent toxic goiter. Antigen B8 plays the role of an immunogenetic marker of endocrine ophthalmopathy.

Adult↗