Biomedical subjects

T S Kolmakova

Publications and source records attributed to T S Kolmakova.

3 recordsLinked to original sources

PubMed1994

[Hormonal interrelationships in symptomatic epilepsy].

The serum and cerebrospinal fluid (CSF) from patients with epilepsy resultant from cerebral leptomeningitis in the fit-free intervals were examined for some hypophyseal and adrenal hormones with reference to the disease course, severity and duration, frequency of the seizures. The levels of hydrocortisone, aldosterone and STH were found stable, while those of prolactin got elevated, especially in males. Hormonal shifts in the serum and CSF appeared significantly different. STH lowered, but prolactin went up only in CSF. The latter increase was related to the seizures frequency.

Adolescent↗

PubMed1983

[Changes in catecholamine metabolism in the brains of rabbits after treatment with anti-brain antibodies and lithium ions].

The authors studied the changes in the activity of tyrosine hydroxylase and dopamine-beta-hydroxylase (the principal enzymes controlling the synthesis of catecholamines) in the whole brain of rabbits on intracisternal injection of immunoglobulin G isolated from the blood of brain-sensitized dogs or from the serum of schizophrenic humans. Also the changes of the content of principal catecholamines (DOPA, noradrenaline, adrenaline) in the animals brain on intravenous injection of lithium chloride after preliminary treatment of the animals with anticerebral antibodies were studied. The changes of the activity of both enzymes in both series of the experiments appeared to be uniformly directed, the fact, that gives one grounds to regard the mechanisms underlying these disturbances as similar. A positive effect of lithium on the catecholamine metabolism in the rabbit CNS was observed. This makes is possible to recommend the model used in this study for examining the efficacy and mode of action of a number of psychotropic drugs.

Animals↗

PubMedDate not supplied

[Characteristics of prolactin secretion in response to different degrees of lesions of the vestibular analyzer].

The prolactin concentration in blood of 58 patients was measured during vestibular crisis and compensation of vestibular disorders. The results were compared with the clinical development of the disease and localization of vestibular problems. Patients with acute vestibular lesions at the central level of vestibular disorders showed a significant increase of prolactin concentrations that was higher than the concentrations in patients with the peripheral vestibular syndrome at the decompensation stage. Hyperprolactinemia during central vestibular dysfunction is viewed as a manifestation of dopamine deficiency of the tuberoinfundibular area. It is suggested that inadequacy of dopaminergic structures is one of the factors reducing adaptive and compensatory capabilities of the vestibular apparatus when its central compartments are injured.

Adult↗