Biomedical subjects

T S Pileggi

Publications and source records attributed to T S Pileggi.

5 recordsLinked to original sources

PubMed2001

Electroconvulsive therapy and cardiovascular complications in patients taking trazodone for insomnia.

BACKGROUND: Trazodone has been used widely to treat insomnia in depressed patients. When used in combination with electroconvulsive therapy (ECT), trazodone has been suspected to cause cardiovascular side effects. METHOD: A retrospective study was done of 100 patients who received ECT with concurrent trazodone. One patient was excluded because permission to review the patient's records had not been given. The remaining 99 patients were matched with control ECT patients. RESULTS: No statistically significant between-group differences were identified in cardiovascular side effects, although a trend toward more orthostatic hypotension was observed in patients taking trazodone. CONCLUSION: Administering low-dose trazodone for insomnia in conjunction with ECT does not appear to increase cardiovascular complications. The true incidence of adverse cardiac events was not higher than 3.66% at a 95% confidence level.

Adult↗

PubMed2000

The effects of electroconvulsive therapy on melatonin.

Although several studies have investigated the impact of various antidepressant medications on melatonin, there are no published reports addressing the effects of electroconvulsive therapy (ECT). Melatonin's major urinary metabolite, 6-sulfatoxymelatonin (6MT), was measured before and after an acute course of ECT. Fourteen subjects diagnosed with major depression who had failed prior pharmacologic therapy were enrolled. 6MT excretion was measured using an enzyme-linked immunosorbent assay test in 24 hour samples separated into daytime and nighttime components. Hamilton Rating Scale for Depression scores showed a significant improvement (p < 0.0001). Data analysis using the Wilcoxon signed rank test demonstrated a significant decrease in 24 hour 6MT post-ECT (p < 0.016) and daytime 6MT (p < 0.008). These results demonstrate an association between a therapeutic response to ECT and decrease in endogenous melatonin production.

Adult↗

PubMed1999

Patient satisfaction with electroconvulsive therapy.

OBJECTIVE: To determine whether patients who have electroconvulsive therapy (ECT) are satisfied with their treatment and demonstrate more favorable attitudes about ECT compared with controls. PATIENTS AND METHODS: We developed a 44-item survey measuring ECT treatment satisfaction and attitudes. The survey was administered to 24 psychiatric inpatients near the end of ECT treatment and 2 weeks later. A modified survey was administered to 24 outpatient controls who had never received ECT and who were recruited from a psychiatry clinic waiting room. RESULTS: Patients who received ECT had positive attitudes about it. For example, 21 (91%) of 24 patient respondents endorsed the statement, "I am glad that I received ECT." Attitude score was significantly higher for the ECT group compared with controls. A higher degree of satisfaction was associated with a higher level of education and younger age. CONCLUSIONS: Patients who received ECT were satisfied with their treatment and had more favorable attitudes about it than patients who did not receive this treatment.

Attitude↗

PubMed1997

Safety and efficacy of electroconvulsive therapy in patients over age 85.

The authors report that electroconvulsive therapy (ECT) can be used safely and effectively in patients over age 85 with concurrent psychiatric and medical problems. Affective and psychotic illnesses are common and debilitating in geriatric patients. This same population has a high frequency of medical comorbidity, which makes it difficult for patients to tolerate adequate doses of standard pharmacotherapies to treat psychiatric problems. Also, many of these individuals are nonresponsive to psychopharmacologic therapies tried. Consequently, ECT becomes an important treatment option in elderly patients.

Aged↗

PubMedDate not supplied

The use of electroconvulsive therapy in pain patients.

Twenty-one patients with primary chronic pain received electroconvulsive therapy (ECT) for concurrent affective symptoms. Twenty of the 21 patients experienced improvement in the level of their pain. ECT can be an effective treatment modality for patients who have chronic pain complicated by affective symptoms.

Aged↗