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Biomedical subjects

T S Popova

Publications and source records attributed to T S Popova.

At least 19 recordsLinked to original sources
PubMed2005

Effect of NO synthesis blocker on electrical activity of rat stomach and small intestine in the early postoperation period.

The effect of NO on electrical activity of the stomach and small intestine was studied in chronic experiments on rats during the early postoperation period. Generation of migrating myoelectric complex in the stomach and small intestine was impaired after abdominal surgery. Administration of NO synthesis blocker suppressed the inhibitory influences, which potentiated generation of the myoelectric complex in the small intestine. Our results suggest that NO is involved in the regulation of the migrating myoelectric complex in the small intestine during postoperation motor disturbances in the gastrointestinal tract.

Action Potentials↗
PubMed2005

Effect of drugs with various mechanisms of action on propulsive activity of the small intestine.

We studied the effect of drugs with various mechanisms of action on propulsive activity of the small intestine in healthy rats. Blockade of the major inhibitory influences realized via nonadrenergic noncholinergic inhibitory effector neurons was not followed by stimulation of intestinal transit. Propulsive activity of the small intestine increased upon treatment with drugs, whose effects are realized via acetylcholine or acetylcholine and serotonin.

Adrenergic beta-Antagonists↗
PubMed2004

[Enteral therapeutic nutrition in the complex therapy and prevention of diseases].

Baseline nutritional impairments, patient's malnutrition, and inadequate correction of metabolic disorders considerably reduce the effects of therapeutic measures, increase the risk of septic and infectious complications, negatively influence the hospital length of stay, increase mortality rates. Concomitant and profound disorders of metabolic homeostasis system in various diseases and critical conditions dictate a multi-component approach to the correction of metabolic disorders requiring specially chosen nutrient compositions and the routes of their administration. The development of currently available nutritional formulae was based on the theory of balanced nutrition reflecting the physiological requirements in nutrients and calories of a healthy person, and also taking into account specific features of pathogenesis, clinical course, disease stage, the nature and extent of metabolic disorders, functional condition of the gastrointestinal tract, the effects of specific nutrients on the intensity of metabolic processes. Nutrition adapted to the patient's disease and the digestive tract functional condition provided by diets containing specific nutrients (arginine, glutamine, omega-3 fatty acids) has a number of advantages over standard nutritional formulae, and poses a directed therapeutic effect. The nutritional formulae "Nutrien" are represented by the standard ("Nutrien Standard"), and semi-elemental ("Nutrien Elemental") formulae, as well as by the formulae of directed effect ("Nutrien Hepa", "Nutrien Nephro", "Nutrien Pulmo", "Nutrien Diabet", "Nutrien Immun").

Child↗
PubMed2004

[Treatment of intestinal insufficiency syndrome in patients with peritonitis].

Results of the treatment of 90 patients with generalized peritonitis and syndrome of intestinal insufficiency were analyzed. In the study group (45 patients) enteral administration of 1% pectin solution and glutamin solution (15-30 g/day) were included in combined therapy. Clinical and laboratory control, radiation monitoring and bacteriological studies carried out for evaluation of efficacy of therapy established. A decrease of endogenous intoxication and time of repair of functional activity of the gastrointestinal tract, immunomodulation, normalization of microbiocenosis of the small intestine. This therapy diminishes the number of complications and lethality.

Glutamine↗
PubMed2003

[Effect of enterally administrated oxygenated water on electrical activity of the small intestine in early postoperative period in rats].

The effect of oxygen, structurally-binded with water (oxygen water), on electrical activity of rat jejunum in early postoperative period. It was shown, that in contrast to effect of 0.9% NaCl, there is normalization of electrical activity parameters (frequency and slow wave amplitude) of jejunum in early postoperative period under the influence of oxygen water.

Action Potentials↗
PubMed2000

Effect of mesodiencephalic modulation on small intestinal mucosa after massive blood loss in rats.

Effect of mesodiencephalic modulation on small intestinal mucosa was studied in rats subjected to massive blood loss. Massive blood loss induced structural changes in intestinal epitheliocytes typical of tissue hypoxia: intraintestinal edema, mitochondrial alterations, and microcirculation disturbances. A single session of mesodiencephalic stimulation carried out 60 min after massive blood loss produced a pronounced adaptive effect, restored disturbed structure of the intestinal villi, and induced compensatory hypertrophy of the mitochondria. This suggests that mesodiencephalic modulation promotes normalization of intracellular energy metabolism, improves the absorption capacity of bordered enterocytes, and restores the disturbed intestinal barrier.

Adaptation, Physiological↗
PubMed1997

[Antimicrobial properties of pectins and their effects on antibiotics].

The influence of food fibres and plant proteins on microorganisms, bacteriophages, antibiotics and penicillinase was studied in vitro. It was shown that pectin was the only agent that had a bactericidal effect on the most widely distributed pathogenic and opportunistic microorganisms and did not influence indigenic microflora. High concentrations of pectin (> 2 per cent) had an inactivating effect on therapeutic bacteriophages. There was also a decrease in the antimicrobial activity of penicillins. The other agents tested i.e. wheat bran, soya isolate and soybean flour had no influence on microorganisms, bacteriophages and antibiotics. No sorption activity of the food fibres and plant proteins with respect to microorganisms and antibiotics or their effect on penicillinase was observed.

Anti-Bacterial Agents↗
PubMed1997

[Parenteral nutrition in the pre- and early postoperative periods. Unsolved problems and contradictions].

The analysis of early published and own clinical investigations dedicated study of parenteral nutrition in pre- and early postoperative periods was represented. Special attention was paid to contradictory conclusions being result of these investigations. The recommendations were given about cases when it is necessary to apply the parenteral nutrition in pre- and early postoperative periods, and when it is necessary to refuse it.

Humans↗