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Biomedical subjects

T S Reeve

Publications and source records attributed to T S Reeve.

At least 73 records · Page 4Linked to original sources
PubMed1985

Is parathyroidectomy of benefit in primary hyperparathyroidism?

A retrospective survey was performed on 265 patients with primary hyperparathyroidism who had received three forms of treatment on a non-randomised basis. 'Successful' surgery (normalisation of serum calcium) was carried out in 142 patients, 'unsuccessful' surgery (persistence of hypercalcaemia after neck exploration) in 33 and no surgery in 90. Patients subjected to surgery were significantly younger than patients in the unoperated group and their serum calcium values at the time of decision were approximately 10 per cent higher. The mean follow-up period was significantly longer in the operated groups. The percentages of patients who had died were similar in each group. Clinical events relating to renal stones depended on the presence or absence of calculi at the time of decision rather than on the method of treatment. At the time of follow-up the prevalence of hypertension, renal impairment and vertebral crush fractures were similar in all three groups. Forearm osteo-densitometry showed a higher bone mineral content in the 'successful' group than in the other two groups. In spite of the selection bias inherent in a study of this kind, it is clear that untreated hyperparathyroidism is compatible with long survival and a lack of demonstrable deleterious effects on kidney and bone.

Bone Diseases↗
PubMed1983

Factors associated with development of foot lesions in the diabetic.

A prospective study was undertaken of 80 diabetic patients over the age of 50 years, with the aim of determining which factors were important in the development of foot lesions. It was found that factors associated with diabetic management, including HbAlc levels and frequency of previous admissions to hospital for diabetic control, appeared to play little part in the development of foot lesions. However, both vascular impairment and cigarette smoking were significantly associated with an increased incidence of lesions, while neuropathy was found to occur commonly in control subjects as well as patients with foot lesions. There was also a significant relationship between the level of patient understanding as measured by a questionnaire and the development of foot lesions. The importance of the education of both patients and doctors concerning the significance of diabetic foot lesions is emphasized.

Aged↗
PubMed1982

Pancreatitis following parathyroid surgery.

While pancreatitis may provide the clue to the diagnosis of hyperparathyroidism preoperatively, the occurrence of pancreatitis following parathyroidectomy is not generally recognized. In this study preoperative and postoperative serum amylase estimations, together with a clinical assessment, were performed on 86 patients undergoing neck exploration for hyperparathyroidism. It was found that postoperative hyperamylasaemia occurred in 35% of the total group, while clinically significant pancreatitis was found in 9% of cases. Pancreatitis was significantly more common when thyroidectomy was performed at the time of parathyroidectomy, occurring in 23% of this group of patients, and may be due to the blunted C-cell response of calcitonin secretion to the induced hypercalcaemia associated with operative manipulation. Careful attention should be paid to postoperative abdominal symptoms, for they may indicate pancreatitis.

Acute Disease↗
PubMed1982

Two aids in oestrogen receptor characterisation.

1. Eighty three breast carcinoma primary and metastatic lesions were submitted for oestrogen receptor (ER) assessment using a standard dextran coated charcoal saturation analysis (0.1 nM-0.8 nM tritiated oestradiol), as well as a single saturating dose (SSD) assay (8 nM tritiated oestradiol). Excellent correlation between the two methods was demonstrated. The single dose assay also provided additional information to aid the construction of ad equate Scatchard plots in those biopsies which exhibited high levels of specific receptor proteins. 2. Three hundred and fifteen consecutive breast carcinoma primary or metastatic lesions, assessed for ER, had imprint cytological examinations to verify the malignancy of the specimen. Seven per cent demonstrated sparse epithelial cellularity with a low or nil malignant cell proportion and showed a lower receptor positivity than the remaining specimens.

Biopsy↗
PubMed1982

Cystic adventitial disease of the popliteal artery: a report of two cases and a review of the literature.

Cystic adventitial disease is a rare condition affecting the wall of certain major arteries. The case histories of two patients presenting to the Royal North Shore Hospital are reviewed. Both patients were young men who presented with unilateral incapacitating calf claudication of sudden onset. Lower limb arteriography on each affected leg revealed a peculiar irregularity of the popliteal artery. Each patient had the popliteal artery explored and similar findings were revealed viz: an extensive cyclic lesion occupying the adventitial layer of the popliteal artery. The cysts were found to contain mucoid material. It was not necessary to enter the arterial lumen in either case. As far as can be established both patients have remained asymptomatic after the simple procedure of evacuating mucoid material from the cysts.

Adult↗
PubMed1981

Oestrogen receptors in breast cancer: greater care in collection.

Care in collection, storage and transportation of breast carcinoma tissue being sent for cytoplasmic oestrogen receptor (O.R) estimations is essential. Failure to observe precise directions may lead to discrepancies that throw doubt on the accuracy of the estimation.

Biopsy↗
PubMed1980

Ruptured abdominal aortic aneurysm: long-term survival after operation.

The long-term follow-up of 65 patients surviving surgery for ruptured abdominal aortic aneurysms is presented. Fifty-six per cent of these patients were alive at the time of review, having survived for a mean period of 36 months. The majority were enjoying a quality of life similar to that experienced before operation. Preexisting ischaemic heart disease did not alter the long-term prognosis. Cumulative survival curves for this group of survivors approximated both the survival curve for the average matched Australian population and similar curves constructed for patients operated upon electively for abdominal aortic aneurysms.

Adult↗
PubMed1978

Preoperative parathyroid identification by ultrasonic scan.

A preliminary report of the use of ultrasonic scans to locate parathyroid tissue before neck exploration is presented. Three patients suffering from hyperparathyroidism had abnormal parathyroid tissue located before surgery. These findings were confirmed at operation. The role of ultrasonic scans of the neck before exploration is discussed.

Aged↗
PubMed1978

Ultrasonic visualization of breast cancer.

Ultrasonic examination of the breast with grey scale echography gives considerable information about the composition of the constituent tissues. This information alone is sometimes of major assistance in the management of the individual patient, particularly in young women with nodular breasts due to dysplastic changes. The method is complementary to the more commonly used visualization techniques and should be considered, particularly in young women, as the first imaging technique to examine palpable masses in the breast, prior to the utilization of ionizing radiation.

Adenocarcinoma, Scirrhous↗
PubMed1978

Parathyroid identification by methylene blue infusion.

A preoperative infusion of methylene blue was employed in 20 patients undergoing neck exploration for hyperparathyroidism. The dye was noted to stain adenomas and hyperplastic glands a deep purple-blue colour. Normal parathyroid tissue stained to a lesser extent or not at all. All unstained parathyroid tissue was normal histologically. Methylene blue infusion is a safe method of more rapidly identifying parathyroid tissue. Its preferential staining of abnormal parathyroid tissue can assist the surgeon in deciding the extent of his parathyroid excision.

Adenoma↗
PubMed1977

Detection and classification of liquid-filled masses in the breast by gray scale echography.

Gray scale ultrasonic visualization of the breast is a simple and safe technique for the detection of liquid-filled masses. Cysts and enlarged ducts as small as 2 mm in diameter can be reliably detected with a greater accuracy than is possible with any other imaging technique. The ultrasonic examination provides considerable information about the nature of the constituent tissues, and this information alone is often sufficient for a determination of the correct treatment.

Breast Diseases↗
PubMed1975

Postoperative complications of thyroidectomy: a comparison of two series at an interval of ten years.

A comparison is presented of the complications found in two series each consisting of 331 consecutive patients undergoing thyroidectomy in the same Unit ten years apart. The overall incidence of postoperative complications has been reduced, particularly in the group of patients having thyroidectomy for thyrotoxicosis following which it is now no greater than after thyroidectomy for benign non-toxic goitre. The techniques used to try to reduce the postoperative complication rate are discussed. The incidence of permenent recurrent laryngeal nerve palsy has been reduced to 0-3% and of permanent hypoparathyroidism to 1-2%. The overall incidence of complications causing permanent disability is now 3-9%.

Adolescent↗