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Biomedical subjects

T Sakamaki

Publications and source records attributed to T Sakamaki.

5 recordsLinked to original sources
PubMed1979

[Clinical study on coxa magna during the treatment in congenital dislocation in the hip (author's transl)].

Enlargement of the femoral head is frequently observed in roentgenographs during the treatment of congenital dislocation of the hip. Clinical study was performed to clarify the definition, etiology and clinical entity of coxa magna. Three hundreds and three hip joints in 247 patients were examined roentgenographically and follow up for an average of 3.1 years. By measuring the longitudinal and cross-sectional lengths of both the femoral heads and necks, we felt that "coxa magna" should be defined as the condition with enlargement of all of these parameters. The incidence of coxa magna was 47% after open reduction, but only 5% after closed reduction. In most cases, coxa magna was roentgenographically evident approximately 10 months after open reduction. On the other hand, it was noticeable 18 months after closed reduction. In the hips without coxa magna, the acetabular index improved remarkably for 6 months following open reduction, but in the hips with coxa magna, it hardly improved. Coxa magna frequently developed femoral head deformity, unless persistent acetabular dysplasia had improved. The incidence of coxa magna appeared to be closely related to surgical intervention performed on acetabular dysplasia.

Age Factors↗
PubMed1978

Crystallization of arginine-, formylmethionine-tyrosine-, and glycine-transfer RNAs from Escherichia coli.

Crystals as large as 0.5 X 0.3 X 0.2 mm of purified arginine-transfer RNA from Escherichia coli have been prepared by a vapour diffusion method. X-ray diffraction photographs showed that the crystals gave reflections up to 3.7 A spacing. They have a trigonal space group P31 2 1 (OR P32 2 1) and cell-dimensions a=97.2, b=97.2, c=94.8A. Crystals of a mercury derivative of this transfer RNA have also been obtained, and an X-ray diffusion photography of one of them is presented. Formylmethionine-transfer RNA from E. coli was crystallized in various forms, and the appearance of the polymorphs was found to depend upon the amount of spermine in the solution from which the crystallization took place. Crystals of tyrosine-transfer RNA and glycine-transfer RNA have also been obtained.

Arginine↗
PubMed1977

Crystal structure of a protein proteinase inhibitor, Streptomyces subtilisin inhibitor, at 2.3 angstrom resolution.

The crystal structure of a protein proteinase inhibitor, Streptomyces subtilisin inhibitor which strongly inhibits bacterial alkaline proteinases, was determined at 2.3 angstrom resolution. The subunit (molecular weight, 11,485) of this dimeric molecule has a unique fold of polypeptide chain with a five-fold anti-parallel beta-sheet structure (about 21% of the 113 amino acid residues) and two small segments of alpha-helices (about 16%). The region around the apparent reactive site, Met(73)-Val(74), is held tight by a combination of various structural features. The conformation of this region seems to have close similarity to that found in substrate analogues of low molecular weight bound to subtilisin BPN'.

Crystallography↗
PubMed1977

The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure.

Study on a diurnal rhythm of plasma aldosterone (PA) and plasma renin activity (PRA) was performed in 8 patients with congestive heart failure. All patients had been digitalized and received diuretics under mild sodium restriction. An obvious diurnal rhythm of PA similar to the normal subjects, with the lowest value in the evening and the highest value in the morning, was observed in 7 of 8 cases, while a diurnal rhythm of PRA was obscure except in one case. The PA generally did not run parallel with PRA. Although the reason of the absence of PRA diurnal rhythm in congestive heart failure was not clear, it was considered that reninangiotensin system did not play a significant role for the development of PA diurnal rhythm in congestive heart failure. The determined PA values were entirely within normal range except in 2 cases, although they were administered the potent diuretics chronically. A high PA value was observed only in early morning in one case, while all determined PA values were extremely high in another case with severe congestive heart failure involved in cardiac liver cirrhosis. The PRA values were relatively low in 2 cases, normal in 5 and high in one.

Adult↗